Identification and functional characterization of plasma membrane amino acid sensors
| Project/Area Number |
19590256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
KANAI Yoshikatsu Osaka University, 医学系研究科, 教授 (60204533)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAMORI Shushi 大阪大学, 医学系研究科, 助教 (90467572)
平田 拓 杏林大学, 医学部, 助教 (60372918)
福富 俊之 杏林大学, 医学部, 助教 (30439187)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRATA Taku 杏林大学, 医学部, 助教 (60372918)
FUKUTOMI Toshiyuki 杏林大学, 医学部, 助教 (30439187)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アミノ酸 / センサー / 受容体 / Ca^<2+>シグナル / 細胞膜 / Ca2+シグナル / トランスポーター / 代謝調節 |
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| Research Abstract |
哺乳類においては、細胞がアミノ酸供給量を感知する機構は明らかにされていない。本研究は、アミノ酸により哺乳類培養細胞に惹起される細胞増殖促進およびp70S6 kinaseのリン酸化には、アミノ酸トランスポーター阻害により抑制されるものと抑制されないものがあることを明らかにし、新たな細胞膜型アミノ酸センサーの存在を示した。また、細胞膜型アミノ酸センサーはCa^<2+>シグナル系に連結する可能性を示した
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Report
(3 results)
Research Products
(99 results)
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[Journal Article] Prognostic significance of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma2009
Author(s)
Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Nakajima T, Mori M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Correlation of angiogenesis with (18) F-FMT and (18)F-FDG uptake in non-small cell lung cancer2009
Author(s)
Kaira K, Oriuchi N, Shimizu K, Ishikita T, Higuchi T, Imai H, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Endou H, Nakajima T, Endo K, Mori M
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung2009
Author(s)
Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Endou H, Nakajima T, Mori M
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Minami S, Ito K, Honma M, Ikebuchi Y, Anzai N, Kanai Y, Nishida T, Tsukita S, Sekine S, Horie T, Suzuki H2009
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[Journal Article] Evaluation of thoracic tumors with (18) F-FMT and (18)F-FDG PET-CT : a clinic opathological study2009
Author(s)
Kaira K, Oriuchi N, Shimizu K, Ishikita T, Higuchi T, Imai H, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Endou H, Nakajima T, Endo K, Mori M
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Journal Title
Int J Cancer 124
Pages: 1152-60
Related Report
Peer Reviewed
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[Journal Article] A novel role of the C-terminus of b 0,+ AT in the ER-Golgi trafficking of the Rbat-b 0,+ AT heterodimeric amino acid transporter2009
Author(s)
Sakamoto S, Chairoungdua A, Nagamori S, Wiriyasermkul P, Promchan K, Tanaka H, Kimura T, Ueda T, Fujimura M, Shigeta Y, Naya Y, Akakura K, Ito H, Endou H, Ichikawa T, Kanai Y
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Journal Title
Biochem J. 417
Pages: 441-8
Related Report
Peer Reviewed
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[Journal Article] Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia2008
Author(s)
Matsuo H, Chiba T, Nagamori S, Nakayama A, Domoto H, Phetdee K, Wiriyasermkul P, Kikuchi Y, Oda T, Nishiyama J, Nakamura T, Morimoto Y, Kamakura K, Sakurai Y, Nonoyama S, Kanai Y, Shinomiya N
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Journal Title
Am J Hum Genet 83
Pages: 744-51
Related Report
Peer Reviewed
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[Journal Article] l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms2008
Author(s)
Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Tanaka S, Ishizuka T, Kanai Y, Endou H, Nakajima T, Mori M
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Journal Title
Cancer Sci 99
Pages: 2380-6
NAID
Related Report
Peer Reviewed
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[Journal Article] Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct2008
Author(s)
Yokoyama H, Anzai N, Ljubojevic M, Ohtsu N, Sakata T, Miyazaki H, Nonoguchi H, Islam R, Onozato M, Tojo A, Tomita K, Kanai Y, Igarashi T, Sabolic I, Endou H
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Journal Title
Cell Physiol Biochem 21
Pages: 269-78
Related Report
Peer Reviewed
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[Journal Article] Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung2008
Author(s)
Kaira K, Oriuchi N, Imai H, Shimizu K, Yanagitani N, Sunaga N, Hisada T, Kawashima O, Iijima H, Ishizuka T, Kanai Y, Endou H, Nakajima T, Mori M
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Journal Title
Pathol Res Pract 204
Pages: 553-61
Related Report
Peer Reviewed
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[Journal Article] Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid2008
Author(s)
Nakagawa H, Hirata T, Terada T, Jutabha P, Miura D, Harada KH, Inoue K, Anzai N, Endou H, Inui K, Kanai Y, Koizumi A
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Journal Title
Basic Clin Pharmacol Toxicol 103
Pages: 1-8
NAID
Related Report
Peer Reviewed
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