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Research on substance P receptor as a novel target for antidepressant therapy using neuroimaging techniques

Research Project

Project/Area Number 19590261
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionNippon Medical School

Principal Investigator

SUZUKI Hidenori  Nippon Medical School, 大学院・医学研究科, 教授 (30221328)

Co-Investigator(Kenkyū-buntansha) OKUBO Yoshiro  日本医科大学, 大学院・医学研究科, 教授 (20213663)
NAGANO Masatoshi  日本医科大学, 医学部, 講師 (60271350)
IKEDA Yumiko  日本医科大学, 医学部, 助教 (10386154)
SAKAI Atsushi  日本医科大学, 医学部, 助教 (30386156)
八幡 憲明  日本医科大学, 医学部, 助教 (70409150)
須原 哲也  独立行政法人 放射線医学総合研究所, グループリーダー (90216490)
Co-Investigator(Renkei-kenkyūsha) SUHARA Tetsuya  独立行政法人放射線医学研究所, 分子イメージング, グループリーダー (90216490)
ITO Hiroshi  独立行政法人放射線医学研究所, 分子イメージング, グループリーダー (20360357)
MATSUDA Tetsuya  玉川大学, 学術研究所, 講師 (30384720)
YAHATA Noriaki  東京大学, 医学系研究科, 特任助教 (70409150)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsうつ・不安動物モデル / 機能的磁気共鳴撮像法 / 気分障害 / サブスタンスP受容体 / セロトニン神経系 / 選択的セロトニン再取り込み阻害薬 / 認知機能 / 陽電子断層撮像法 / サブスタンスP神経系 / 5-HT1Aセロトニン受容体 / NK-1タキキニン受容体 / 脳由来神経栄養因子 / 前頭前野 / 霊長類 / PETリガンド
Research Abstract

NK-1 receptors in the human brain were visualized and quantified using ^<18>F-FE-SPA-RQ with PET. The prefrontal and the limbic cortices, the regions responsible for the depression and the anxiety disorders, expressed substantial amount of NK-1 receptors. An fMRI study revealed neural substrates influenced by an antidepressant during the cognitive task performance. The combined application of both noninvasive neuroimaging techniques could be of great utility for development and evaluation of drugs to treat psychiatric disorders.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (40 results)

All 2010 2009 2008 2007 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (12 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Cerebral activation associated with speech sound discrimination during the diotic listening task: An fMRI study.2010

    • Author(s)
      Ikeda Y, Yahata N, Takahashi H, Koeda M, Asai K, Okubo Y, Suzuki H
    • Journal Title

      Neurosci Res 67

      Pages: 65-71

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic stress enhances synaptic plasticity due to disinhibition in the anterior cingulate cortex and induces hyper-locomotion in mice.2010

    • Author(s)
      Ito H, Nagano M, Suzuki H, Murakoshi T
    • Journal Title

      Neuropharmacol 58

      Pages: 746-757

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic stress enhances synaptic plasticity due to disinhibition in the anterior cingulate cortex and induces hyper-locomotion in mice.2010

    • Author(s)
      Ito H, Suzuki H.(4人中3番目)
    • Journal Title

      Neuropharmacol. 58

      Pages: 746-757

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral activation associated with speech sound discrimination during the diotic listening task : an fMRl study.2010

    • Author(s)
      Ikeda Y, Suzuki H.(7人中7番目)
    • Journal Title

      Neurosci.Res. 67

      Pages: 65-71

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei.2009

    • Author(s)
      Saitow F, Murano M, Suzuki H
    • Journal Title

      J Neurophysiol 101

      Pages: 1361-1374

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei.2009

    • Author(s)
      Saitow F, Suzuki H.(3人中3番目)
    • Journal Title

      J Neurophysiol. 101

      Pages: 1361-1374

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia.2008

    • Author(s)
      Ikeda Y, Yahata N, Ito I, Nagano M, Toyota T, Yoshikawa T, Okubo Y, Suzuki H
    • Journal Title

      Schizophr Res 101

      Pages: 58-66

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of neural cell adhesion molecule signaling in glial cell line-derived neurotrophic factor-induced analgesia in a rat model of neuropathic pain.2008

    • Author(s)
      Sakai A, Asada M, Seno N, Suzuki H
    • Journal Title

      Pain 137

      Pages: 378-388

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal dexamethasone exposure affects anxiety-like behaviour and neuroendocrine systems in an age-dependent manner.2008

    • Author(s)
      Nagano M, Ozawa H, Suzuki H
    • Journal Title

      Neurosci Res 60

      Pages: 364-371

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase in hemokinin-1 mRNA in the spinal cord during the early phase of a neuropathic pain state.2008

    • Author(s)
      Matsumura T, Sakai A, Nagano M, Sawada M, Suzuki H, Umino M, Suzuki, H
    • Journal Title

      Br J Pharmacol 155

      Pages: 767-774

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic fluoxetine bidirectionally modulates potentiating effects of serotonin on the hippocampal mossy fiber synaptic transmission.2008

    • Author(s)
      Kobayashi K, Ikeda Y, Haneda E, Suzuki H
    • Journal Title

      J Neurosci 28

      Pages: 6272-6280

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.2008

    • Author(s)
      Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T
    • Journal Title

      Mol Brain 1

      Pages: 6-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of NK1 receptor in the human brain using PET with 18F-FE-SPA-RQ.2008

    • Author(s)
      Okumura M, Arakawa R, Ito H, Seki C, Takahashi H, Takano H, Haneda E, Nakao R, Suzuki H, Suzuki K, Okubo Y, Suhara T
    • Journal Title

      J Nucl Med 49

      Pages: 1749-1755

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain.2008

    • Author(s)
      Sato C, Sakai A, Ikeda Y, Suzuki H, Sakamoto A
    • Journal Title

      Anesth Analg 106

      Pages: 313-320

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal dexamethasone exposure affects anxiety-like behavior and neuroendocrine systems in an age-dependent manner2008

    • Author(s)
      Nagano, M.
    • Journal Title

      Neurosci. Res. 60

      Pages: 364-371

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of NK_1 receptor in human brain using positron emission tomography with [18^F]FE-SPA-RQ2008

    • Author(s)
      Okumura, M.
    • Journal Title

      J Nucl. Med. 49

      Pages: 1749-1755

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic fluoxetine bidirectionally modulates potentiating effects of serotonin on the hippocampal mossy fiber synaptic transmission2008

    • Author(s)
      Kobayashi, K.
    • Journal Title

      J Neurosci. 28

      Pages: 6272-6280

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged analgesic effect of epidural ropivacaine in a rat model of neuropathic pain.2008

    • Author(s)
      Sato, C.
    • Journal Title

      Anesthesia & Analgesia 106

      Pages: 313-320

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non-depilated mouse model.2007

    • Author(s)
      Katayama M, Aoki E, Suzuki H, Kawana S
    • Journal Title

      Exp Dermatol 16

      Pages: 553-560

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural responses to human voice and hemisphere dominance for lexical-semantic processing:An fMRI study.2007

    • Author(s)
      Koeda, M.
    • Journal Title

      Methods of Information in Medicine 46

      Pages: 247-250

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non-depilated mouse model.2007

    • Author(s)
      Katayama, M.
    • Journal Title

      Experimental Dermatology 16

      Pages: 553-560

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reversal of hippocampal neuronal maturation by serotonergic antidepressants.

    • Author(s)
      Kobayashi K, Ikeda Y, Sakai A, Yamasaki N, Haneda E, Miyakawa T, Suzuki H
    • Journal Title

      Proc Natl Acad Sci USA (In press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of antipsychotic and anxiolytic agents on stress-induced degranulation of mouse dermal mast cells.

    • Author(s)
      Shimoda T, Liang Z, Suzuki H, Kawana S
    • Journal Title

      Clin Exp Dermatol (In press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 抗不安薬ならびにプラセボがヒト情動機構に及ぼす効果の検討:薬理学的fMRI研究2009

    • Author(s)
      八幡憲明、鈴木秀典(8人中7番目)
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都国際会館 (京都府)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Reversal of hippocampal neuronal maturation by chronic inhibition of serotonin reuptake.2009

    • Author(s)
      Kobayashi K, Ikeda Y, Sakai A, Suzuki H
    • Organizer
      36th International Union of Physiological Sciences
    • Place of Presentation
      Kyoto (Japan)
    • Related Report
      2009 Final Research Report
  • [Presentation] Multiple effects of chronic fluoxetine on hippocampal synaptic transmission and behaviors in mice2008

    • Author(s)
      Kobayashi, K.
    • Organizer
      Neuroscience 2008, the Society for Neuroscience's 38^<th> annual meeting
    • Place of Presentation
      Washington, DCUSA
    • Year and Date
      2008-11-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chronic SSRI changes the maturation state of dentate granule cells.2008

    • Author(s)
      Kobayashi K, Ikeda Y, Sakai A, Suzuki H
    • Organizer
      6th FENS forum of European Neuroscience
    • Place of Presentation
      Geneva (Switzerland)
    • Related Report
      2009 Final Research Report
  • [Presentation] Chronic SSRI treatment increases behavioral instability and anxiety-related behaviors in association with reduced hippocampal mossy fiber synaptic facilitation.2008

    • Author(s)
      Ikeda Y, Kobayashi K, Suzuki H
    • Organizer
      6th FENS forum of European Neuroscience
    • Place of Presentation
      Geneva (Switzerland)
    • Related Report
      2009 Final Research Report
  • [Presentation] Multiple effects of chronic fluoxetine on hippocampal synaptic transmission and behaviors in mice.2008

    • Author(s)
      Kobayashi K, Ikeda Y, Suzuki H
    • Organizer
      Neuroscience 2008, the Society for Neuroscience's 38th annual meeting
    • Place of Presentation
      Washington DC (USA)
    • Related Report
      2009 Final Research Report
  • [Presentation] An fMRI study on auditory selective attention in diotic listening paradigm.2008

    • Author(s)
      Ikeda Y, Yahata N, Takahashi H, Koeda M, Okubo Y, Suzuki H
    • Organizer
      Neuroscience 2008, the Society for Neuroscience's 38th annual meeting
    • Place of Presentation
      Washington DC (USA)
    • Related Report
      2009 Final Research Report
  • [Presentation] Modulation of the human emotional system by subacute fatigue load: an fMRI study.2008

    • Author(s)
      Yahata N, Sasaki T, Matsumoto S, Matsuda T, Suzuki H, Okubo Y, Sakai K
    • Organizer
      Neuroscience 2008, the Society for Neuroscience's 38th annual meeting
    • Place of Presentation
      Washington DC (USA)
    • Related Report
      2009 Final Research Report
  • [Presentation] Impaired dentate granule cell functions in alpha-CaMKII deficient mice.2007

    • Author(s)
      Kobayashi K, Ikeda Y, Yamasaki N, Takao K, Suzuki H, Miyakawa T
    • Organizer
      7th IBRO World Congress of Neuroscience
    • Place of Presentation
      Melbourne Convention Centre (Australia)
    • Related Report
      2009 Final Research Report
  • [Presentation] Serum neurotrophic factor levels are associated with pathophysiological features of schizophrenia.2007

    • Author(s)
      Ikeda Y, Ito I, Yahata N, Nagano M, Toyota T, Okubo Y, Suzuki H.
    • Organizer
      7th IBRO World Congress of Neuroscience
    • Place of Presentation
      Melbourne Convention Centre (Australia)
    • Related Report
      2009 Final Research Report
  • [Presentation] Applicability of high-resolution imaging systems to observe in vivo mapping of central NK1 receptors in laboratory animals.2007

    • Author(s)
      Haneda E, Higuchi M, Maeda J, Inaji M, Okauchi T, Suzuki K, Suzuki H, Suhara T
    • Organizer
      7th IBRO World Congress of Neuroscience
    • Place of Presentation
      Melbourne Convention Centre (Australia)
    • Related Report
      2009 Final Research Report
  • [Presentation] Applicability of high-resolution imaging systems to observe in vivo mapping of central NK1 receptors in laboratory animals.2007

    • Author(s)
      Haneda, E.
    • Organizer
      7th IBRO World Congress of Neuroscience.
    • Place of Presentation
      Melbourne Convention Centre(Australia)
    • Related Report
      2007 Annual Research Report
  • [Book] クルグス診療科(4)基礎医学第4章2008

    • Author(s)
      鈴木秀典
    • Publisher
      星和書店
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.nms.ac.jp/nms/pharmacol/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.nms.ac.jp/nms/pharmacol/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.nms.ac.jp/nms/pharmacol/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.nms.ac.jp/nms/pharmacol/

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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