Does ATP / adenosine system protect sympathetic nerve of an ischemic heart in life-style related diseases model rat?

• Project/Area Number: 19590263
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Mukogawa Women's University
• Principal Investigator: SHINOZUKA Kazumasa Mukogawa Women's University, 薬学部, 教授 (50117777)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 中枢 / 末梢神経 / 虚血再灌流 / ATP / アデノシン / メタボリックシンドローム / 虚血心臓 / 血管交感神経 / 保護作用 / 血管内皮細胞 / 虚血再潅流 / 生活習慣病 / 薬理学 / 脳・神経

Research Abstract

自然発症高血圧ラット(SHR)や生活習慣病モデル動物(SHR.Cg-Leprcp/NDmcrats)において、交感神経終末部のATP・アデノシン受容体が機能不全を起こしていることを見いだした。一方、低酸素時には心臓から大量のアデノシンが放出され、酸素再通気後もその放出は増加し続けることを見いだした。本結果より、生活習慣病の進展とともに交感神経伝達の抑制性調節機構が破綻し、これがこの病態におけるプレコンディショニングの破綻の一部に関与している可能性が示唆された。

Research Products

• [Journal Article] Chronic production of peroxynitrite in the vascular wall impairs vasorelaxation function in SHR/NDmcr-cp rats, an animal model of metabolic syndrome. (2009)
  • Author(s): Kagota S, Tada Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: J Pharmacol Sci. 109(4) Pages: 556-564
  • NAID: 10025735851
  • Peer Reviewed
• [Journal Article] Effects of ATP on the intracellular calcium level in the osteoblastic TBR31-2 cell line.Effects of ATP on the intracellular calcium level in the osteoblastic TBR31-2 cell line. (2009)
  • Author(s): Nishii N, Nejime N, Yamauchi C, Yanai N, Shinozuka K, Nakabayashi T.
  • Journal Title: Biol Pharm Bull. 32(1) Pages: 18-23
  • Peer Reviewed
• [Journal Article] Possible participation of chloride ion channels in ATP release from cancer cells in suspension. (2009)
  • Author(s): Nejime N, Kagota S, Tada Y, Nakamura K, Hashimoto M, Kunitomo M, Shinozuka K.
  • Journal Title: Clin Exp Pharmacol Physiol. 36(3) Pages: 278-282
  • Peer Reviewed
• [Journal Article] Possible Participation of chloride ion channels in ATP release from cancer cells in suspension. (2009)
  • Author(s): Nejime N, 等
  • Journal Title: Clin Exp Pharmacol Physiol 377 Pages: 278-282
  • Peer Reviewed
• [Journal Article] 代謝症候群モデルラット尾動脈交感神経伝達に対するニコランジルの影響 (2008)
  • Author(s): 橋本道男、鄭婀美、田邊洋子、禰占奈美江、多田有加里、籠田智美、篠塚和正
  • Journal Title: Therapeutic Res. 29 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Effect of P2 receptor on the intracellular calcium increase by cancer cells in human umbilical vein endothelial cells. (2008)
  • Author(s): Nejime N, Tanaka N, Yoshihara R, Kagota S, Yoshikawa N, Nakamura K, Kunitomo M, Hashimoto M, Shinozuka K
  • Journal Title: Naunyn Schmiedebergs Arch Pharmacol. 377(4-6) Pages: 429-436
  • Peer Reviewed
• [Journal Article] 代謝症候群モデルラツト尾動脈交感神経伝達に対するニコランジルの影響 (2008)
  • Author(s): 橋本道男, 等
  • Journal Title: Therapeutic Research 29 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Effect of P2 receptor on the intracellular calcium increase by cancer cells in human umbilical vein endothelial cells. (2008)
  • Author(s): Nejime N, 等
  • Journal Title: Naunyn Schmiedebergs Arch Pharmacol 377 Pages: 429-436
  • Peer Reviewed
• [Journal Article] Peroxynitrite is Involved in the dysfunction of vasorelaxation in SHR/NDmcr-cp rats, spontaneously hypertensive obese rats. (2007)
  • Author(s): Kagota S, Tada Y, Kubota Y, Nejime N, Yamaguchi Y, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: J Cardiovasc Pharmacol. 50(6) Pages: 677-685
  • Peer Reviewed
• [Journal Article] Impaired effect of salt loading on nitric oxide-mediated relaxation in aortas from stroke-prone spontaneously hypertensive rats. (2007)
  • Author(s): Kagota S, Kubota Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: Clin Exp Pharmacol Physiol. 34(1-2) Pages: 48-54
  • Peer Reviewed
• [Journal Article] ATP modulates the release of noradrenaline through two different prejunctional receptors on the adrenergic nerves of rat prostate. (2007)
  • Author(s): Morikawa T, Tanaka N, Kubota Y, Mizuno H, Nakamura K, Kunitomo M, Shinozuka K.
  • Journal Title: Clin Exp Pharmacol Physiol. 34(7) Pages: 601-605
  • Peer Reviewed
• [Journal Article] Nicorandil may change the sympathetic nerve activity of SHR.Cg-Leprcp/NDmcr (SHR-cp) rats. (2007)
  • Author(s): Tei A, Tabuchi M. Nejime N, Kubota Y, Kagota S, Higashino H, Hashimoto M. Shinozuka K.
  • Journal Title: Clin Exp Pharmacol Physiol. 34
  • Peer Reviewed
• [Journal Article] Influence of hypertension on dysfunction of regulation of adrenergic neurotransmission in SHR.Cg-Lepr^<cp>/NDmcr (SHR-cp) rats. (2007)
  • Author(s): Nejime N, Kagota S, Yoshihara R, Tanaka N, Tei A, Kubota Y, Nakamura K, Kunitomo M. Shinozuka K.
  • Journal Title: Clin Exp Pharmacol Physiol. 34
  • Peer Reviewed
• [Journal Article] ATP modulates the release of noradrenaline through two different prejunctional receptors on the adrenergic nerves of rat prostate (2007)
  • Author(s): Morikawa T
  • Journal Title: Clinical and Experimental Pharmacology and Physiology 34 Pages: 601-605
  • Peer Reviewed
• [Journal Article] Nicorandil may change the sympathetic nerve activity of SHR.Cg-Leprcp/NDmcr(SHR-cp)rats (2007)
  • Author(s): Tei, A
  • Journal Title: Clinical and Experimental Pharmacology and Physiology 34 Pages: 31-32
  • Peer Reviewed
• [Journal Article] Enfluence of hypertension on dysfunction of regulation of adrenergic neurotransmission in SHR.CG-Leprcp/NDmcr(SHR-cp)rats (2007)
  • Author(s): Nejime, N
  • Journal Title: Clinical and Experimental Pharmacology and Physiology 34 Pages: 33-34
  • Peer Reviewed
• [Presentation] Effect of cancer cells on the intracellular calcium ion levels in human umbilical vein endothelial cells via P2Y receptor (2008)
  • Author(s): Nejime N
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-19
• [Presentation] Changes in cardiac function in SHRSP.Z-Lepr^<fa>/IzmDmcr rats with metabolic syndrome (2008)
  • Author(s): Tada Y.
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-19
• [Presentation] Effect of nicorandil on the release of noradrenaline from rat caudal artery ラット尾動脈からのノルアドレナリン遊離に対するニコランジルの影響 (2008)
  • Author(s): Tei A
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] 代謝症候群モデルラット尾動脈交感神経伝達に対するニコランジルの影響 (2007)
  • Author(s): 橋本道男
  • Organizer: 第20回ニコランジル研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-20
• [Presentation] Cancer cells effect on intracellular calcium ion levels of vascular endothelial cells via P2Y receptors. (2007)
  • Author(s): Nejime N
  • Organizer: 5^<th> International Symposium on Receptor Mechanisms, Signal Transductions and Drug Effects
  • Place of Presentation: 静岡
• [Presentation] Changes in cardiac chronotropic and inotropic responses to beta and muscarinic receptor agonists in SHR/NDmcr-cp rats, an animal model of metabolic syndrome. (2007)
  • Author(s): Tada Y
  • Organizer: 5^<th> International Symposium on Receptor Mechanisms, Signal Transductions and Drug Effects
  • Place of Presentation: 静岡