Cyp26b1 regulates the expression of the gut-homing receptor CCR9 in T cells.

• Project/Area Number: 19590264
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Tokushima Bunri University
• Principal Investigator: TAKEUCHI Hajime Tokushima Bunri University, 香川薬学部, 助教 (00421298)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 炎症・免疫 / レチノイン酸 / 生体分子 / 発現制御 / 免疫学 / ホーミング

Research Abstract

All-trans retinoic acid (AtRA) is an essential regulator in lymphocyte. Concentrations of AtRA are maintained by the balance between synthesis and degradation. CYP26 metabolizes AtRA into inactive derivatives. We found that Cyp26b1, one of CYP26 enzymes, was expressed in T cells in gut-related lymphoid organs. The expression level of Cyp26b1 was significantly related to the AtRA-induced expression of the gut-homing receptor.

Research Products

• [Journal Article] Cyp26b1 regulates the expression of the gut-homing receptor CCR9 in T cells (2009)
  • Author(s): Takeuchi, H., Yokoto, A., Ohoka, Y., Iwata, M.
  • Journal Title: Proceedings of the 16th International Conference on Cytochrome P450 Pages: 165-168
• [Journal Article] Cyp26b1 regulates the expression of the gut homing receptor CCR9 in T cells (2009)
  • Author(s): Takeuchi, H., Yokota, A., Ohoka, Y., Iwata, M.
  • Journal Title: Proceedings of the 16^<th> International Conference on Cytochrome P450 Pages: 165-168
• [Journal Article] 食物アレルギーにおけるレチノイン酸代謝酵素の役割の解明 (2008)
  • Author(s): 竹内一、岩田誠
  • Journal Title: 食に関する助成研究調査報告書 No.21 Pages: 117-124
  • NAID: 40016311666
• [Journal Article] 食物アレルギーにおけるレチノイン酸代謝酵素の役割の解明 (2008)
  • Author(s): 竹内一
  • Journal Title: 食に関する助成研究調査報告書 第21号 Pages: 117-124
  • NAID: 40016311666
• [Presentation] Retinoid X receptor agonists and organotins markedly enhance the retinoic acid-induced CCR9 expression of T cells (2009)
  • Author(s): 竹内一
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Cyp26b1による小腸ホーミング受容体CCR9の発現制御 (2009)
  • Author(s): 竹内一
  • Organizer: 第8回四国免疫フォーラム
  • Place of Presentation: 香川
  • Year and Date: 2009-06-27
• [Presentation] Cyp26b1 regulates the expression of the gut-homing receptor CCR9 in T cells (2009)
  • Author(s): Takeuchi, H.
  • Organizer: 16th International Conference on Cytochrome
  • Place of Presentation: 沖縄
  • Year and Date: 2009-06-25
• [Presentation] Cyp26b1 regulates the expression of the gut-homing receptor CCR9 in T cells (2009)
  • Author(s): Hajime Takeuchi
  • Organizer: 16^<th> International Conference on Cytochrome P450
  • Place of Presentation: 沖縄県万国津梁館
  • Year and Date: 2009-06-25
• [Presentation] Cyp26b1 regulates the expression of the gut-homing receptor CCR9 in T cells (2008)
  • Author(s): 竹内一
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Cyp26bl regulates the expression of the gut-homing Receptor CCR9 in T cells. (2008)
  • Author(s): 竹内一
  • Organizer: 日本免疫学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2008-12-02
• [Presentation] Th1・Th2細胞におけるレチノイン酸による小腸へのホーミングのインプリンティング (2007)
  • Author(s): 竹内一
  • Organizer: 第37回日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Remarks]
  • URL: http://kp.bunri-u.ac.jp/kph05/index.html
• [Remarks]
  • URL: http://kp.bunri-u.ac.jp/kph05/index.html