Development of new therapeutic strategy for rescuing cardiomyopathy using small heat shock proteins

• Project/Area Number: 19590266
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: National Research Institute for Child Health and Development
• Principal Investigator: SANBE Atsushi National Research Institute for Child Health and Development, 薬剤治療研究部実験薬理研究室, 室長 (30425706)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 循環 / 心筋症 / ストレスタンパク質 / アミロイド / ランスジェニックマウス / デスミン / トランスジェニックマウス / α-β-クリスタリン

Research Abstract

アミロイドオリゴマーの形成を阻害することにより、デスミン心筋症の治療が可能か否かを検討した。ストレスタンパク質(HSP)発現誘導剤(ゲラニルゲラニルアセトン)の長期投与は、デスミン心筋症モデルマウスの心筋のアミロイドオリゴマー量を低下させ、デスミン心筋症病態を軽減した。HSPの発現誘導によりデスミン心筋症治療が可能と考えられる。

Research Products

• [Journal Article] Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy. (2009)
  • Author(s): Sanbe A., Daicho T., Mizutani R., Endo T., Miyauchi N., Yamauchi J., Tanonaka K., Glabe C. and Tanoue A.
  • Journal Title: PloS One 4 Pages: 5351-5351
• [Journal Article] Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy (2009)
  • Author(s): Sanbe A., et al.
  • Journal Title: PloS One 4
  • Peer Reviewed
• [Journal Article] Alpha-1 adrenoceptor is required for normal male sexual function (2007)
  • Author(s): Sanbe A., et. al.
  • Journal Title: British Journal of Pharmacology 152 Pages: 332-340
  • Peer Reviewed
• [Journal Article] Alcohol preference in mice lacking the Avprla vasopressin receptor
  • Author(s): Sanbe A., et. al.
  • Journal Title: American Journal of Physiology (In press)
  • Peer Reviewed
• [Presentation] Protective effects of HSP22 on Desmin related cardiomyopathy (2008)
  • Author(s): Sanbe A
  • Organizer: The 25th Annual Meeting of ISHR Japanese Section
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2008-12-05
• [Presentation] Induction of small heat shock protein by geranylgeranylacetone is protective against CryAB R120G cardiomyopathy P 107 (2008)
  • Author(s): Sanbe A, Daicho T, Mizutani R, Endo T, Miyauchi N, Yamauchi J, Tanonaka K, Glabe C and Tanoue A.
  • Organizer: International Society for Heart Research (ISHR)
  • Place of Presentation: North American Section meeting, Cincinnati, OH, USA
• [Presentation] Enhancement of HSP22 induction by geranylgeranylacetone (GGA) in desmin-related cardiomyopathy. (2008)
  • Author(s): Sanbe A, Daicho T, Mizutani R, Endo T, Miyauchi N, Yamauchi J, Tanonaka K, Glabe C and Tanoue A.
  • Organizer: The 80th Scientific Sessions of American Heart Association
  • Place of Presentation: New Orleans, USA.
• [Presentation] Enhancement of HSP22 induction by geranylgeranylacetone (GGA) in desmin-related cardiomyopathy (2008)
  • Author(s): Sanbe A
  • Organizer: The 80th Scientific Sessions of American Heart Association. New Orleans, USA
  • Place of Presentation: New Orleans, USA
• [Presentation] Aryl Hydrocarbon Receptorを介したタバコ主流煙抽出物の神経堤細胞遊走抑制作用 (2008)
  • Author(s): 水谷 玲子
  • Organizer: 日本薬理学会年会
  • Place of Presentation: 横浜
• [Presentation] Alteration of male sexual function ln alphal A-, 1B- and 1D-adrenergic receptor triple knockout mouse (2007)
  • Author(s): Sanbe A.
  • Organizer: 7th World Congress on Neurohypophysial Hormones
  • Place of Presentation: Rosenburg, Germany
• [Presentation] タバコ抽出物はAryl hydrocarbon receptorを介して神経提細胞遊走を抑制する (2007)
  • Author(s): 水谷 玲子
  • Organizer: 日本薬理学会年会
  • Place of Presentation: 熊本
• [Remarks]
  • URL: http://www.nch.go.jp/pharmac/index.html