Functional characterization of candidate disease genes identified by the efficient bi-allelic insertional mutagenesis

• Project/Area Number: 19590274
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kanazawa University
• Principal Investigator: SUZUKI Takeshi Kanazawa University, がん研究所, 教授 (30262075)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: ゲノム / 挿入変異 / がん遺伝子 / がん抑制遺伝子 / ウイルス / レトロウイルス / 疾患モデルマウス / がん分子標的 / ゲノム不安定性

Research Abstract

がんの発症や悪性化の分子メカニズムを解明するためには、原因となる遺伝子の同定とその機能解析が重要となる。我々は、ウイルス感染発がんモデルマウスを用いて、発がんに関係する遺伝子を網羅的に同定し、その機能や相互作用を解析している。同定された標的遺伝子のなかでも、タンパク質のメチル化・脱メチル化に関与する酵素群は、がんの新しい分子標的の候補として、特に注目して解析を進めている。

Research Products

• [Journal Article] Meis1 regulates the development of endothelial cells in zebrafish (2008)
  • Author(s): Minehata K, Kawahara A, Suzuki T
  • Journal Title: Biochem. Biophys. Res. Commun 374 Pages: 647-52
  • Peer Reviewed
• [Journal Article] ウイルス挿入変異によるがん関連遺伝子の同定 (2008)
  • Author(s): Suzuki T
  • Journal Title: 細胞 Vol.40, No.2 Pages: 56-59
• [Journal Article] Meisl regulates the development of endothelial cells in zebrafish. (2008)
  • Author(s): 峯畑健一
  • Journal Title: Biochem. Biophys. Res. Commun. 374 Pages: 647-652
  • Peer Reviewed
• [Journal Article] ウイルス挿入変異によるがん関連遺伝子の同定 (2008)
  • Author(s): 鈴木 健之
  • Journal Title: 細胞 40 Pages: 56-59
• [Presentation] Identification of novel cancer genes using retroviral insertional mutagenesis in mice (2008)
  • Author(s): Suzuki T, Ishimura A, Terashima M, Suzuki Y, Sugano S, Yoshida M
  • Organizer: 第31回分子生物学会年会・第81 回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] 新規がん抑制遺伝子候補Jmjd5 の機能解析 (2008)
  • Author(s): Ishimura A, Minehata K, Terashima M, Hara T, Suzuki T
  • Organizer: 第31回分子生物学会年会・第81 回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Identification of novel cancer genes using retroviral inserlional mutagenesis in mice. (2008)
  • Author(s): Suzuki T
  • Organizer: 第31回分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] Involvement of histone methyltransferases and demethylases in cancer identified by retroviral insertional mutagenesis (2008)
  • Author(s): Suzuki T
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] Involvement of histone methyltransferases and demethylases in canceridentified by retroviral insertional mutagenesis. (2008)
  • Author(s): 鈴木健之
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] ウイルス感染マウスを用いた新しいがん分子標的の探索 (2008)
  • Author(s): Suzuki T
  • Organizer: The 22nd Meeting of the Society for the study of Mammalian Genetics
  • Place of Presentation: 東京
  • Year and Date: 2008-09-12
• [Presentation] ウイルス感染マウスを用いた新しいがん分子標的の探索 (2008)
  • Author(s): 鈴木健之
  • Organizer: The 22nd Meeting of the Society for the studyof Mammalian Genetics
  • Place of Presentation: 東京
  • Year and Date: 2008-09-12
• [Presentation] Identification of the genes involved in mouse retrovirus-induced leukemia/ lymphoma by high-throughput retroviral tagging (2008)
  • Author(s): Suzuki T, Ishimura A, Terashima M
  • Organizer: The 8th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路島
  • Year and Date: 2008-09-10
• [Presentation] Identification of novel cancer genes using retroviral insertional mutagenesis in mice. (2008)
  • Author(s): 鈴木健之
  • Organizer: The 8^<th> Awaji International Forum on Infectionand Immunity
  • Place of Presentation: Awaji, Hyogo
  • Year and Date: 2008-09-10
• [Presentation] Identification of novel cancer genes using retroviral insertional mutagenesis in mice. (2008)
  • Author(s): Suzuki T
  • Organizer: The Joint Symposium of the 3rd International Symposium of Institutes Network and Hot Spring Harbor- Global COE Symposium
  • Place of Presentation: 別府
  • Year and Date: 2008-02-01
• [Presentation] Identification of novel cancer genes using retroviral insertional mutagenesis in mice (2007)
  • Author(s): Suzuki T
  • Organizer: 第30回分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] Tumor suppressor gene identification using retroviral insertional mutagenesis in Bloom syndrome model mice (2007)
  • Author(s): Suzuki T
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] High-throughput retroviral tagging for identification of the genes involved in mouse retrovirus induced lymphoma (2007)
  • Author(s): Suzuki T, Ishimura A
  • Organizer: The Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路島
  • Year and Date: 2007-09-01
• [Presentation] High-throughput retroviral tagging for identification of the genes involved in mouse retrovirus induced lymphoma (2007)
  • Author(s): Suzuki T, Ishimura A
  • Organizer: The Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji,Hyogo
  • Year and Date: 2007-09-01