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Cell polarization mechanisms by nectin-afadin adhesion system and Par polarity proteins

Research Project

Project/Area Number 19590276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionKumamoto University

Principal Investigator

FUJITA Naoyuki  Kumamoto University, 大学院・医学薬学研究部, 准教授 (50403192)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords細胞間接着 / 細胞極性 / ネクチン / アファディン / Par-3 / 細胞極性因子 / AJ / TJ
Research Abstract

本研究によって私共は、細胞極性因子Par-3は上皮細胞のアドヘレスジャンクション(AJ)とタイトジャンクション(TJ)の形成に必須の役割を果たすが、接着分子ネクチンによって形成される初期の細胞接着には必須でないことを見出した。Par-3はネクチンとその裏打ち分子アファディンとの結合を促進するが、一方、アファディンはPar-3とネクチンの結合には関わらない。アファディンとネクチンとの結合だけではAJとTJの形成には十分ではなく、Par-3とアファディンが協調的に働いて、AJとTJの形成を制御している。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2 : implications for cellular morphology2007

    • Author(s)
      Nakata S, Fujita N, Kitagawa Y, Okamoto R, Ogita H, Takai Y.
    • Journal Title

      J.Biol. Chem 282

      Pages: 37815-27825

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions2007

    • Author(s)
      Ooshio T, Fujita N, Yamada A, Sato T, Kitagawa Y, Okamoto R, Nakata S, Miki A, Irie K, Takai Y.
    • Journal Title

      J. Cell Sci 120

      Pages: 2352-2365

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of nectins in cell adhesions : cooperation with other cell adhesion molecules and growth factor receptors2007

    • Author(s)
      Sakisaka T, Ikeda W, Ogita H, Fujita N, Takai Y.
    • Journal Title

      Curr. Opin. Cell Biol 19

      Pages: 593-602

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions2007

    • Author(s)
      Takako Ooshio
    • Journal Title

      J. Cell Sci 15

      Pages: 2352-2365

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新しいリン脂質結合タンパク質SGIP1αによる初期エンドソームでのEGF受容体のソーティング2008

    • Author(s)
      上江洲章吉、菊池直也、梅田一彰、藤田直之、中西宏之
    • Organizer
      BMB2008(熊大・院・医学薬学研究部・細胞情報薬理学)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 新しいリン脂質結合タンパク質SGIP1αによる初期エンドソームでのE GF受容体のソーティング機構2008

    • Author(s)
      上江洲 章吉
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Binding of afadin to SHP-2 stimulates dephosphorylation of PDGF receptor and inhibits the PDGF-induced Ras activation2007

    • Author(s)
      中田信輔、藤田直之、北川雄一、扇田久和、高井義美
    • Organizer
      第66回日本癌学会学術総会(阪大院・分子生物学、神大院・医・分子細胞生物学)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Binding of afadin to SHP-2 stimulates dephosphorylation of PDGF receptor and inhibits the PDGF-induced Ras activation2007

    • Author(s)
      中田 信輔
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Book] Current Opinion in Cell Biology2007

    • Author(s)
      Toshiaki Sakisaka
    • Total Pages
      10
    • Publisher
      ELSEVIER
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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