Studies on the mechanism of nucleo/cytoplasmic shuttling of sphingosine kinase

• Project/Area Number: 19590309
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kobe University
• Principal Investigator: NAKAMURA Shunichi Kobe University, 大学院医学研究科, 教授 (40155833)
• Co-Investigator(Kenkyū-buntansha): OKADA Tarou 神戸大学, 大学院・医学研究科, 准教授 (80304088)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: シグナル伝達 / 酵素 / 脂質 / 生体分子 / 生理活性 / 核排出シグナル / 核移行シグナル

Research Abstract

SK2のアミノ酸配列にこれまでに報告の無い核排出シグナルを有し、以前に報告した核移行シグナルと共に両者のバランスによってSK2が細胞質/核間シャトルが調節されていることを明らかにした。

Research Products

• [Journal Article] Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system (2009)
  • Author(s): Okada, T., Kajimoto, T., Jahangeer, S., Nakamura, S.
  • Journal Title: Cell. Signal 21 Pages: 7-13
  • Peer Reviewed
• [Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model (2008)
  • Author(s): Nishiuma, T., Nishimura, Y., Okada, T., Kuramoto, E., Kotani, Y., Jahangeer, S., Nakamura, S.
  • Journal Title: Am. J. Physiol. Lung Cell. Mol. Physiol. 294
  • Peer Reviewed
• [Journal Article] Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model (2008)
  • Author(s): Nishiuma, T., Nishimura, Y., Okada, T., Kuramoto, E., Kotani, Y., Jahangeer, S., & Nakamura, S.
  • Journal Title: Am. J. Physiol. Lung Cell. Mo1. Physiol. 294
  • Peer Reviewed
• [Journal Article] Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons (2007)
  • Author(s): Kajimoto, T., Okada, T., Yu, F., Goparaju, S. K., Jahangeer, S., Nakamura. S.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 3429-3440
  • NAID: 10024355377
  • Peer Reviewed
• [Journal Article] Sphingosine kinase 1 regulates differentiation of human and mouse lung fibroblasts mediated by TGF{beta}1 (2007)
  • Author(s): Kono, Y., Nishiuma, T., Nishimura, Y., Kotani, Y., Okada, T., Nakamura, S., Yokoyama M.
  • Journal Title: Am. J. Respir. Cell. Mol. Biol. 37 Pages: 395-404
  • Peer Reviewed
• [Journal Article] Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2 (2007)
  • Author(s): Ding, G., Sonoda, H., Yu, H., Kajimoto, T., Goparaju, S. K., Jahangeer, S., Okada, T., Nakamura, S.
  • Journal Title: J. Biol. Chem. 282 Pages: 27493-27502
  • Peer Reviewed
• [Journal Article] Requirement of phospholipase D for ilimaquinone-induced Golgi membrane fragmentation (2007)
  • Author(s): Sonoda, H., Okada, T., Jahangeer, S., Nakamura, S.
  • Journal Title: J. Biol. Chem. 282 Pages: 34085-34092
  • Peer Reviewed
• [Journal Article] Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons (2007)
  • Author(s): Kajimoto, T., Okada, Y., Yu, H., Goparaju, S., Jahangeer, S. & Nakamura, S.
  • Journal Title: Mol. Cell. Biol. 27 Pages: 3429-3440
  • NAID: 10024355377
  • Peer Reviewed
• [Journal Article] Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2 (2007)
  • Author(s): Ding G, Sonoda H, Yu H, Kajimoto T, Goparaju SK, Jahangeer S, Okada T, Nakamura S.
  • Journal Title: J. Biol. Chem. 282 Pages: 27493-27502
  • Peer Reviewed
• [Journal Article] Requirement of phospholipase D for ilimaquinone-induced Golgi membrane fragmentation (2007)
  • Author(s): Sonoda, H., Okada, T., Jahangeer, S., and Nakamura, S.
  • Journal Title: J. Biol. Chem. 282 Pages: 34085-34092
  • Peer Reviewed
• [Presentation] Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons (2008)
  • Author(s): Nakamura, S.
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Waterville Valley (USA)
  • Year and Date: 2008-07-27
• [Presentation] スフィンゴシンキナーゼ2によるエキソソーム放出の調節 (2008)
  • Author(s): 中村俊一, 岡田太郎
  • Organizer: 第3回スフィンゴテラピィ(STC)研究会
  • Place of Presentation: 大山(鳥取)
  • Year and Date: 2008-07-18
• [Presentation] スフィンゴシンキナーゼ2によるエキソソーム放出の調節 (2008)
  • Author(s): 中村俊一, 岡田太郎
  • Organizer: 第3回スフィンゴテラピイ(STC)研究会
  • Place of Presentation: 鳥取
• [Presentation] スフィンゴ脂質による神経伝達物質放出機構の解析 (2008)
  • Author(s): 中村俊一
  • Organizer: 平成20年度特定領域研究「統合脳」5領域 夏のフークショップ
  • Place of Presentation: 北海道
• [Presentation] スフィンゴシン1リン酸による神経伝達物質放出機構の解析 (2008)
  • Author(s): 中村俊一
  • Organizer: 特定領域研究「統合脳」冬の公開シンポジウム
  • Place of Presentation: 東京
• [Presentation] スフィンゴシン1リン酸による新たな神経機能調節 (2007)
  • Author(s): 中村俊一
  • Organizer: 第2回 第2回スフィンゴテラピィ(STC)研究会
  • Place of Presentation: 鳥取
• [Presentation] Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons (2007)
  • Author(s): Goparaju Sravan, Jahangeer Saleem
  • Organizer: 第49回日本資質生化学会
  • Place of Presentation: 札幌
• [Presentation] Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons (2007)
  • Author(s): Shun-ichi Nakamura
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Watervilie Valley Resort
• [Presentation] A novel fucntion of sphingosine 1-phosphate in hippocampal neuronsBiochemical and genetic basis of neurological diseases and novel therapeutic approaches (2007)
  • Author(s): Shun-ichi Nakamura
  • Place of Presentation: Warsaw