| Project/Area Number |
19590318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Jichi Medical University |
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Principal Investigator |
TOMINAGA Shinichi Jichi Medical University, 医学部, 教授 (70155571)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGISAWA Ken 自治医科大学, 医学部, 教授 (50182366)
OHTA Satoshi 自治医科大学, 医学部, 助教 (40528428)
TAKEZAKO Naoki 独立行政法人国立病院機構災害医療センター, 診療部, 医長 (80424026)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ST2遺伝子 / 糖鎖修飾 / 抗炎症作用 / アレルギー・ぜんそく / シグナル伝達 / タンパク質 / 糖鎖 / 免疫学 |
|---|
| Research Abstract |
ST2 protein is induced in the case of allergic diseases, such as bronchial asthma, in parallel with disease activity. Possible usage of the functional region of the ST2 protein as a novel drug against inflammatory reaction in allergic diseases, we clarified that core protein itself is able to suppress inflammation, and its glycosylation enhanced the inhibitory activity. We are now identifying minimum effective region of the ST2 protein.
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