Genome diversities in genes for NK cell function and their clinical and biological roles.
| Project/Area Number |
19590330
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NARUSE Taeko Tokyo Medical and Dental University, 難治疾患研究所, 特任教員 (80422476)
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| Co-Investigator(Kenkyū-buntansha) |
木村 彰方 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Akinori 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 分子遺伝学 / NKレセプター / ゲノム多様性 / リガンド多型 / 遺伝子多型 / 遺伝子多型解析 / 自己免疫疾患 / マイクロサテライトマーカー |
|---|
| Research Abstract |
We have investigated genome diversity of ULBP/RAET1 gene family and found that ULBP4 gene was the most polymorphic with 8 single nucleotide polymorphisms in exons and an insertion/deletion and (GT)n repeat polymorphisms in the promoter region. In addition, specific allele of KIR-3DL1 was associated with the resistance to HIV/AIDS. These observations suggested that allelic diversities of NK receptors and ligands lead to the functional difference of NK cells.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] rans-species polymorphism of the Mhc class II DRB-like gene in banded penguins (genus Spheniscus)2009
Author(s)
Kikkawa EF, Tsuda TT, Sumiyama D, Naruse TK, Fukuda M, Kurita M, Wilson RP, LeMaho Y, Miller GD, Tsuda M, Murata K, Kulski JK, Inoko H.
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Journal Title
Immunogenetics 61
Pages: 341-352
Related Report
Peer Reviewed
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[Journal Article] HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis2009
Author(s)
Kominami S, Tanabe N, Ota M, Naruse T, Katsuyama Y, Nakanishi N, Tomoike H, Sakuma M, Shirato K, Takahashi M, Shibata H, Yasunami M, Chen Z, Kasahara Y, Tatsumi K, Kuriyama T, Kimura A
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Journal Title
J Hum Genet 54(2)
Pages: 108-114
NAID
Related Report
Peer Reviewed
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[Journal Article] Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease.2009
Author(s)
Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Takahashi TY, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE, Izumi T, Kimura A
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Journal Title
Hum Genet 126
Pages: 539-547
Related Report
Peer Reviewed
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[Journal Article] Trans-species polymorphism of the Mhc class II DRB-like gene in banded penguins(genus Spheniscus).2009
Author(s)
Kikkawa EF, Tsuda TT, Sumiyama D, Naruse TK, Fukuda M, Kurita M, Wilson RP, LeMaho Y, Miller GD, Tsuda M, Murata K, Kulski JK, Inoko H.
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Journal Title
Immunogenetics 61
Pages: 341-352
Related Report
Peer Reviewed
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[Journal Article] Re-evaluation of heterogeneity in HLA-B*510101 associated with Behcet's disease2008
Author(s)
Takemoto Y, Naruse TK, Namba K, Kitaichi N, Ota M, Shindo Y, Mizuki N, Gul A, Madanat W, Shams H, Davatchi F, Inoko H, Ohno S, Kimura A
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Journal Title
Tissue Antigens 72
Pages: 347-353
Related Report
Peer Reviewed
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