Analysis of novel maternal effect gene, Ces5
| Project/Area Number |
19590333
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Human genetics
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
TASHIRO Fumi Osaka University, 医学系研究科, 助教 (40136213)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
倭 英司 大阪大学, 医学系研究科, 准教授 (20273667)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMATO Eiji 大阪大学, 医学系研究科, 准教授 (20273667)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 発生・分化 / 遺伝子 / ノックアウト |
|---|
| Research Abstract |
ES細胞の分化や未分化状態に関与する遺伝子は、生体における発生・分化過程の理解にも有用と考えられ、未分化ES細胞に特異的に発現する遺伝子を単離しCes5と名付けた。作製したノックアウトマウスの雌の不妊を認め、新規なmaternal effect遺伝子と考えられた。電子顕微鏡を用いた解析結果より、Ces5は卵の細胞質内の繊維状構造物の構築に関与し、構造体の成分あるいは構築に必須の蛋白であり、初期胚の発生に重要な役割を持つことが示唆された
|
Report
(3 results)
Research Products
(12 results)
-
[Journal Article] Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia2009
Author(s)
Toyoda, S., Miyazaki, T., Miyazaki, S., Yoshimura, T., Yamamoto, M., Tashiro, F., Yamato, Y. & Miyazaki, J.
-
Journal Title
Dev. Biol 325
Pages: 238-248
Related Report
Peer Reviewed
-
-
[Journal Article] Gene expression pattern of Cue110 : a member of the uncharacterized UPF0224 gene family preferentially expressed in germ cells2007
Author(s)
Yoshimura, T., Miyazaki, T., Toyoda, S., Miyazaki, S., Tashiro, F., Yamato, E. & Miyazaki, J.
-
Journal Title
Gene Expression Patterns 8
Pages: 27-35
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
