| Project/Area Number |
19590339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUZUKI Takashi Tohoku University, 大学院・医学系研究科, 教授 (10261629)
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| Co-Investigator(Kenkyū-buntansha) |
笹野 公伸 東北大学, 大学院・医学系研究科, 教授 (50187142)
林 慎一 東北大学, 医学部, 教授 (60144862)
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| Co-Investigator(Renkei-kenkyūsha) |
SASANO Hironobu 東北大学, 大学院・医学系研究科, 教授 (50187142)
HAYASHI Shin-ichi 東北大学, 大学院・医学系研究科, 教授 (60144862)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 乳癌 / アンドロゲン / アロマターゼ / アロマターゼ阻害剤 / 17βHSD2 / Androgen / Aromatase / Breast Cancer / Tissue Concentration |
|---|
| Research Abstract |
Previous studies have demonstrated that androgens exert anti-proliferative effects in the breast carcinoma, but the detailed mechanisms remain unclear. Results of our present study demonstrated that (1) androgen actions were markedly suppressed by estrogens in the breast carcinoma, (2) an estrogen-producing enzyme, aromatase, also plays as a negative regulator of intratumoral androgen production, (3) androgen actions were increased in the breast carcinoma treated with an aromatase inhibitor, and (4) 17βHSD2 was identified as an androgen-induced gene in the breast carcinoma, which was involved in the anti-proliferative effects of androgens on the breast carcinoma.
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