Biological analysis and pathological application of HNF-4α

• Project/Area Number: 19590341
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Niigata University
• Principal Investigator: 梅津 哉 Niigata University, 医歯学総合病院, 准教授 (50251799)
• Co-Investigator(Kenkyū-buntansha): NAITO Makoto 新潟大学, 医歯学系, 教授 (30045786) ; HASEGAWA Go 新潟大学, 医歯学系, 准教授 (90251800)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 核内受容体 / HNF-4α / 組織発現 / 卵巣癌 / 胃癌 / 粘液関連遺伝子 / 大腸癌 / 個体発生

Research Abstract

核内受容体HNF-4αのP1およびP2プロモーター由来アイソフォーム(P1, P2-HNF4α)は臓器によって発現が異なる。胃癌や粘液産生性卵巣癌に特徴的HNF-4αアイソフォームの発現が観察され、粘液形質との関連が明らかにされた。膵ランゲルハンス島ではP2-HNF4αがα細胞に発現することを確認し、HNF4αの糖代謝への関与について新たな知見を得た。

Research Products

• [Journal Article] Expression of liver X receptor α and lipid metabolism in granulocyte- macrophage colony-stimulating factorinduced human monocyte-derived macrophage (2009)
  • Author(s): Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M.
  • Journal Title: Pathol Int 59(59) Pages: 152-160
  • NAID: 10027379414
• [Journal Article] Protein expression of nuclear receptors in human and murine tissues (2009)
  • Author(s): Takegoshi S, Jiang S, Ohashi R, Savchenko AS, Iwanari H, Tanaka T, Hasegawa G, Hamakubo T, Kodama T, Naito M.
  • Journal Title: Pathol Int 59(2) Pages: 61-72
  • NAID: 10027379056
• [Journal Article] Protein expression of nuclear receptors in human and murine tissues. (2009)
  • Author(s): Takegoshi S, Jiang S, Ohashi R, et al.
  • Journal Title: Pathology International 59 Pages: 61-72
  • Peer Reviewed
• [Journal Article] Expression of liver X receptor α and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage. (2009)
  • Author(s): Kazawa T, Kawasaki T, Sakamoto A, et al.
  • Journal Title: Pathology International 59 Pages: 152-160
  • Peer Reviewed
• [Journal Article] Expression of hepatocyte nuclear factor 4α in primary ovarian mucinous tumors. (2008)
  • Author(s): Sugai M, Umezu H, Yamamoto T, Jiang S, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M
  • Journal Title: Pathol Int 58(11) Pages: 681-6
  • NAID: 10027378224
• [Journal Article] Macrophage differentiation and function in health and disease (2008)
  • Author(s): Naito M
  • Journal Title: Pathol Int 58(3) Pages: 143-155
  • NAID: 10027375901
• [Journal Article] Expression of hepatocyte nuclear factor 4α in primary ovarian mucinous tumors. (2008)
  • Author(s): Sugai M, Umezu H, Yamamoto T, et al.
  • Journal Title: Pathology International 58 Pages: 681-686
  • NAID: 10027378224
  • Peer Reviewed
• [Journal Article] Macrophage differentiation and function in health and disease. (2008)
  • Author(s): 内藤 眞
  • Journal Title: Pathol Int 58(3) Pages: 143-155
  • NAID: 10027375901
  • Peer Reviewed
• [Journal Article] Down-regulated P1 promoter-driven HNF4α expression in human colorectal carcinoma is a new prognostic factor against liver metastasis (2007)
  • Author(s): Oshima T, Kawasaki T, Ohashi R, Hasegawa G, Jiang S, Umezu H, Aoyagi Y, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M
  • Journal Title: Pathol Int 57 Pages: 82-90
• [Journal Article] Down-regulated Promoter-driven HNF4α expression in human colorectal carcinoma is a new prognostic factor against liver metastasis. (2007)
  • Author(s): 大島智子、梅津哉, 他10名
  • Journal Title: Pathol Int 57 Pages: 82-90
  • Peer Reviewed
• [Journal Article] Expression of androgen receptor through androgen-converting enzymes is associated with biological aggressiveness in prostate cancer. (2007)
  • Author(s): 若生康一、梅津哉, 他9名
  • Journal Title: J Clin Pathol 61(4) Pages: 448-54
  • Peer Reviewed
• [Presentation] 核内受容体の組織内細胞内局在の検討 (2008)
  • Author(s): 内藤眞
  • Organizer: 第19回日本レチノイド研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-22
• [Presentation] 核内受容体の組織内、細胞内局在の検討 (2008)
  • Author(s): 内藤 眞
  • Organizer: 第19回日本レチノイド研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-22
• [Presentation] 卵巣腫瘍におけるHepatocyte nuclear factor 4α(HNF4α)の発現と組織型推定の可能性 (2008)
  • Author(s): 須貝美佳、梅津哉、山本尚、姜淑英、内藤眞
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 肺線癌におけるTTF-1(ThyroidTranscription Factor-1)の発現例、非発現例の検討 (2008)
  • Author(s): 國井亮祐、長谷川剛、山本尚、梅津哉、姜淑英、大橋瑠子、内藤眞
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 肺線癌におけるTTF-1(Thyroid Transcription Factor-1)の発現例、非発現例の検討 (2008)
  • Author(s): 國井亮祐, 長谷川剛, 山本 尚, 梅津 哉, 姜淑英, 大橋瑠子, 内藤 眞
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 肝類洞壁細胞における核内受容体の発現 (2007)
  • Author(s): 竹越聡、内藤眞他5名
  • Organizer: 第21回日本肝類洞壁細胞研究会
  • Place of Presentation: 松山市
  • Year and Date: 2007-12-24
• [Presentation] 肝類洞壁細胞における核内受容体の発現。 (2007)
  • Author(s): 竹越 聡、内藤 眞, 他5名
  • Organizer: 第21回日本肝類洞壁細胞研究会
  • Place of Presentation: 松山市
  • Year and Date: 2007-12-24