Biological analysis and pathological application of HNF-4α
Project/Area Number |
19590341
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Niigata University |
Principal Investigator |
梅津 哉 Niigata University, 医歯学総合病院, 准教授 (50251799)
|
Co-Investigator(Kenkyū-buntansha) |
NAITO Makoto 新潟大学, 医歯学系, 教授 (30045786)
HASEGAWA Go 新潟大学, 医歯学系, 准教授 (90251800)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 核内受容体 / HNF-4α / 組織発現 / 卵巣癌 / 胃癌 / 粘液関連遺伝子 / 大腸癌 / 個体発生 |
Research Abstract |
核内受容体HNF-4αのP1およびP2プロモーター由来アイソフォーム(P1, P2-HNF4α)は臓器によって発現が異なる。胃癌や粘液産生性卵巣癌に特徴的HNF-4αアイソフォームの発現が観察され、粘液形質との関連が明らかにされた。膵ランゲルハンス島ではP2-HNF4αがα細胞に発現することを確認し、HNF4αの糖代謝への関与について新たな知見を得た。
|
Report
(3 results)
Research Products
(18 results)
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[Journal Article] Expression of liver X receptor α and lipid metabolism in granulocyte- macrophage colony-stimulating factorinduced human monocyte-derived macrophage2009
Author(s)
Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M.
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Journal Title
Pathol Int 59(59)
Pages: 152-160
NAID
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[Journal Article] Down-regulated P1 promoter-driven HNF4α expression in human colorectal carcinoma is a new prognostic factor against liver metastasis2007
Author(s)
Oshima T, Kawasaki T, Ohashi R, Hasegawa G, Jiang S, Umezu H, Aoyagi Y, Iwanari H, Tanaka T, Hamakubo T, Kodama T, Naito M
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Journal Title
Pathol Int 57
Pages: 82-90
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