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Gene Amplification of MYC and its coamplification with genes coding receptor tyrosine kinase in solid carcinomas

Research Project

Project/Area Number 19590342
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKanazawa University

Principal Investigator

OOI Akishi  Kanazawa University, 医学系, 教授 (50160411)

Co-Investigator(Kenkyū-buntansha) 藤村 隆  金沢大学, 医学部附属病院, 講師 (50262580)
西村 元一  金沢大学, 医学部附属病院, 講師 (90208215)
井口 雅史  金沢大学, 医学系研究科, 助教 (90401918)
土橋 洋  自治医科大学, 医学部, 准教授 (90231456)
Co-Investigator(Renkei-kenkyūsha) HUJIMURA Takashi  金沢大学, 附属病院, 講師 (50262580)
INOKUCHI Masashi  金沢大学, 医学系, 助教 (90401918)
DOBASHI Yoh  自治医科大学, 医学部, 准教授 (90231456)
NISHIMURA Motoichi  金沢大学, 附属病院, 特任教授 (90208215)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
KeywordsMYC / 遺伝子増幅 / 受容体型チロシンキナーゼ / 固形癌 / FISH / 乳癌 / ERBB2 / ウェスタンブロット / 蛋白過剰発現 / Myc / EGFR / gene amplification / gallbladder cancer / breast cancer / Western blot
Research Abstract

胆嚢癌および乳癌について、DNA転写物質をコードするMYC, 容体型チロシンキナーゼをコードするERBB2, EGFR の遺伝子の増幅をfluorescence in situ hybridizationを用いて検索した。胆嚢癌では97 例中3例にMYCの増幅があり、1例でERBB2とEGFR、1例でERBB2の同時増幅を認めた。乳癌では91例中31例にMYCの増幅がみられ、このうち10例にERBB2の同時増幅をみとめた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinomas2009

    • Author(s)
      Akishi Ooi, Shioto Suzuki, Kumiko Nakazawa, Jun Itakura, Issei Imoto , Hiroyuki Nakamura, Yoh Dobashi.
    • Journal Title

      Anticancer Res 29

      Pages: 19-26

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical and diverse involvement of the Akt/mTOR signaling in human lung carcinomas2009

    • Author(s)
      Dobashi Y, Suzuki S, Matsubara H, Kimura M, Endo S, Ooi A.
    • Journal Title

      Cancer 115

      Pages: 107-118

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene amplification of Myc and its Coamplification with ERBB2 and EGFR in Gallbladder Adenocarcinoma2009

    • Author(s)
      Akishi Ooi
    • Journal Title

      Anticancer research 29

      Pages: 19-26

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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