Clinicopathologic and biologic study oriented for the new classification of EBV-associated lymphoproliferative disorder
| Project/Area Number |
19590344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
NAKAMURA Shigeo Nagoya University, 大学院・医学系・研究科, 教授 (80180363)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 病理 / 癌 / 加齢 / 病理学 / 免疫機能異常 / EBV / 悪性リンパ腫 |
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| Research Abstract |
加齢性EBV関連B細胞リンパ増殖異常症は、本邦より我々が世界に初めて発信した疾患概念である。世界に類例なき高齢化に向かいつつある本邦において、初めて認識が可能であった疾患である。2008年9月に公刊されたWHO分類第4版に正式な項目として掲載された。本疾患の正式掲載以降、欧米でも同様の疾患の報告とともに、加齢に伴う免疫機能の低下の関与とその臨床病理学的重要性が急速に指摘されつつある。当該期間において、これらEBV関連リンパ増殖症の免疫監視機構の解明を含む体系的理解、新分類の画定、さらに新たな治療法、予防法の開発を目指して研究を遂行した。
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Report
(3 results)
Research Products
(66 results)
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[Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders: comparison with EBV-positive classical Hodgkin lymphoma in elderly patients2008
Author(s)
Asano N, Yamamoto K, Tamaru JI, Oyama T, Ishida F, Ohshima K, Yoshino T, Nakamura N, Mori S, Yoshie O, Shimoyama Y, Morishima Y, Kinoshita T, Nakamura S.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Japanese phase II study of (90)Y-ibritumomab tiuxetan in patients with relapsed or refractory indolent B-cell lymphoma2008
Author(s)
Tobinai K, Watanabe T, Ogura M, Morishima Y, Hotta T, Ishizawa K, Itoh K, Okamoto SI, Taniwaki M, Tsukamoto N, Okumura H, Terauchi T, Nawano S, Matsusako M, Matsuno Y, Nakamura S, Mori S, Ohashi Y, Hayashi M, Endo K.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma2008
Author(s)
Suzuki N, Katsusihma H, Takeuchi K, Nakamura S, Ishizawa K, Ishii S, Moriya T, DeCoteau JF, Miura I, Ichinohasama R.
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Journal Title
Cancer Genet Cytogenet 186(1)
Pages: 54-7
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Peer Reviewed
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[Journal Article] De novo CD5+ diffuse large B-cell lymphoma : results of a detailed clinicopathological review in 120 patients2008
Author(s)
Yamaguchi M, Nakamura N, Suzuki R, KagamiY, Okamoto M, Ichinohasama R, Yoshino T, Suzumiya J, Murase T, Miura I, Ohshima K, Nishikori M, Tamaru JI, Taniwaki M, Hirano M, Morishima Y, Ueda R, Shiku H, Nakamura S.
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Journal Title
Haematologica 93(8)
Pages: 1195-202
Related Report
Peer Reviewed
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[Journal Article] Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan2008
Author(s)
Shimada K, Matsue K, Yamamoto K, Murase T, Ichikawa N, Okamoto M, Niitsu N, Kosugi H, Tsukamoto N, Miwa H, Asaoku H, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T.
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Journal Title
J Clin Oncol 26(19)
Pages: 3189-92
Related Report
Peer Reviewed
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[Journal Article] Nodal T/NK-cell lymphoma of nasal type : a clinicopathological study of six cases2008
Author(s)
Takahashi E, Asano N, Li C, Tanaka T, Shimada K, Shimada S, Yoshino T, Kojima M, Hara K, Eimoto T, Nakamura S.
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Journal Title
Histopathology 52(5)
Pages: 585-96
Related Report
Peer Reviewed
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[Journal Article] Definition, Diagnosis, and Management of Intravascular Large B Cell Lymphoma : Proposals and Perspectives From an International Consensus Meeting2007
Author(s)
Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S.
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Journal Title
J Clin Oncol 25(21)
Pages: 3168-73
Related Report
Peer Reviewed
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[Journal Article] Intravascular large B-cell lymphoma (IVLBCL) : a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD52007
Author(s)
Murase T, Yamaguchi M, Suzuki R, Okamoto M, Sato Y, Tamaru JI, Kojima M, Miura I, Mori N, Yoshino T, Nakamura S.
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Journal Title
Blood 109(2)
Pages: 478-85
Related Report
Peer Reviewed
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[Journal Article] Cytotoxic molecule expression is predictive of prognosis in Hodgkin's-like anaplastic large cell lymphoma2007
Author(s)
Asano N, Suzuki R, Matsuo K, Kagami Y, Ishida F, Tamaru JI, Jin GS, Sato Y Shimoyama Y, Yoshino T, Morishima Y, Nakamura S.
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Journal Title
Histopathology 50(6)
Pages: 705-15
Related Report
Peer Reviewed
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[Book] Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)WHO Classification of Tumours of Haematopietic and Lymphoid Tissues.2008
Author(s)
Isaacson PG, Chott A, Nakamura S, Muller-Hermelink HK, Harris NL, Swerdlow SH.
Publisher
IARS Press, Lyon(Swedlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW eds.)
Related Report
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[Book] Muller-Hermelink HK, Jaffe ES.Peripheral T-cell lymphoma, not otherwise specified.WHO Classification of Tumours of Haematopietic and Lymphoid Tissues(Swedlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW eds.)2008
Author(s)
Pileri SA, Ralfkiaer E, Weisenburger DD, Nakamura S, Sng I, Nakamura S
Publisher
IARS Press, Lyon
Related Report
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