Importance of anti-apoptotic pathway via transcription factor PBX1

• Project/Area Number: 19590346
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
• Principal Investigator: TOMITA Yasuhiko Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses, 病理・細胞診断科, 部長 (60263266)
• Co-Investigator(Kenkyū-buntansha): 青笹 克之 大阪大学, 大学院・医学系研究科, 教授 (30115985)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: がん / 転移 / 抗アポトーシス / Valosin-containing protein / Pre B cell leukemia transcription factor 1 (PBX1) / Lung cancer / prognosis / transcription factor / Pre B cell leukemia transcription factor 1 / E74-like factor 2 / 転写因子

Research Abstract

研究者はValosin-containing protein (VCP)の転写制御因子としてPre B cell leukemia transcription factor 1 (PBX1)を同定した。本研究は、これまでの研究を発展させ、癌細胞のVCP転写メカニズムをさらに詳細に検討すること、転写因子PBX1の重要性についての詳細な検討を行なうことを目的として行なった。その結果、VCP転写にはPBX1以外にE74-like factor 2が重要な役割をすること、肺腫瘍においては、PBX1よりむしろそのファミリーのPBX2が転写に重要な役割を果たすことが確認された。

Research Products

• [Journal Article] Evaluation of Chemotherapy response in osteosarcoma with FDG-PET (2009)
  • Author(s): Hamada K, Tomita Y, Inoue A, Fujimoto T, Hashimoto N, Myoui A, Yoshikawa H, Hatazawa J
  • Journal Title: Ann. Nuclear Med. 23 Pages: 89-95
  • NAID: 10025135442
  • Peer Reviewed
• [Journal Article] Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma (2009)
  • Author(s): Qiu Y, Morii E, Tomita Y, Zhang B, Matsumura A, Kitaichi M, Okumura M, Aozasa K
  • Journal Title: Cancer Sci. 100 Pages: 1198-1209
  • NAID: 10027191874
  • Peer Reviewed
• [Journal Article] Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma (2009)
  • Author(s): Qiu Y, Tomita Y, et al.
  • Journal Title: Cancer Science (印刷中)
  • NAID: 10027191874
  • Peer Reviewed
• [Journal Article] Prognostic significance of phosphorylated FOXO1 expression in soft tissue sarcoma (2009)
  • Author(s): Zhang B, Tomita Y, et al.
  • Journal Title: Annals of Surgical Oncology (印刷中)
  • Peer Reviewed
• [Journal Article] A case of intraepithelial neoplasia in the oropharynx detected by endoscopic screening with narrow-band imaging videoendoscopy. (2008)
  • Author(s): Matsumura M, Uedo N, Ishihara R, Iishi H, Fujii T, Tomita Y
  • Journal Title: Gastrointestinal endoscopy 68 Pages: 147-148
  • Peer Reviewed
• [Journal Article] Mucosa-associated lymphoid tissue lymphoma studied with FDG-PET: a comparison with CT and endoscopic findings (2008)
  • Author(s): Enomoto K, Hamada K, Inohara H, Higuchi I, Tomita Y, Kubo T, Hatazawa J
  • Journal Title: Ann. Nuclear Med. 22 Pages: 261-267
  • NAID: 10021280943
  • Peer Reviewed
• [Journal Article] FDG PET imaging of myxofibrosarcoma on the sphenoid sinus (2008)
  • Author(s): Enomoto K, Inohara H, Hamada K, Tamura M, Tomita Y, Kubo T, Hatazawa J
  • Journal Title: Clin Nucl Med. 33 Pages: 421-422
  • Peer Reviewed
• [Journal Article] E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth (2008)
  • Author(s): Qiu Y, Morii E, Zhang B, Tomita Y, Aozasa K
  • Journal Title: Exp Mol Pathol. 84 Pages: 226-229
  • Peer Reviewed
• [Journal Article] The role of fine-needle aspiration cytology and magnetic resonance imaging in the management of parotid mass lesions. (2008)
  • Author(s): Inohara H, Akahani S, Yamamoto Y, Hattori K, Tomiyama Y, Tomita Y, Aozasa K, Kubo T
  • Journal Title: Acta Otolaryngol. 10 Pages: 1-7
  • Peer Reviewed
• [Journal Article] FDG-PET evaluation of chondromyxoid fibroma of left ilium (2008)
  • Author(s): Hamada K, Tomita Y, Konishi E, Jin YF, Fujimoto T, Outani H, Tamiya H, Naka N, Araki N
  • Journal Title: Clin Nucl Med. 34 Pages: 15-17
  • Peer Reviewed
• [Journal Article] 18F-FDG PET analysis of schwannoma: increase of SUVmax in the delayed scan is correlated with elevated VEGF/VPF expression in the tumors (2008)
  • Author(s): Hamada K, Tomita YQiu Y, Tomoeda M, Ueda T, Tamai N, Hashimoto N, Yoshikawa H, Aozasa K, Hatazawa J
  • Journal Title: Skeletal Radiol. 38 Pages: 261-266
  • Peer Reviewed
• [Journal Article] 18F-FDG PET of Musculoskeletal Tumors : A Correlation with the Expression of Glucose Transporter I and Hexokinase II (2008)
  • Author(s): Hamada K, Tomita Y, et al.
  • Journal Title: Ann. Nuclear Med. 22 Pages: 699-705
  • Peer Reviewed
• [Journal Article] E74-like factor regulates Valosin-containing protein expression (2007)
  • Author(s): Zhang B, Tomita Y, Qiu Y, He J, Morii E, Noguchi S, Aozasa K
  • Journal Title: Biochem. Biophys. Res. Commun. 356 Pages: 536-541
  • Peer Reviewed
• [Journal Article] Prognostic significance of CD100 expression in soft tissue sarcoma (2007)
  • Author(s): Ch'ng ES, Tomita Y, Zhang B, He J, Hoshida Y, Qiu Y, Morii E, Nakamichi I, Hamada K, Ueda T, Aozasa K
  • Journal Title: Cancer 110 Pages: 164-172
  • Peer Reviewed
• [Journal Article] Expression of Hepatoma-derived growth factor is correlated with tumor recurrence of esophageal carcinoma (2007)
  • Author(s): Yamamoto S, Tomita Y, Hoshida Y, Morii E, Yasuda T, Doki Y, Aozasa K, Uyama H, Nakamura H, Monden M
  • Journal Title: Ann. Surg. Oncol. 14 Pages: 2141-2149
  • Peer Reviewed
• [Journal Article] Correlation between promoter hypermethylation of GSTP1 and response to chemotherapy in diffuse large B- cell lymphoma (2007)
  • Author(s): Nakamichi I, Tomita Y, Zhang B, Sugiyama H, Kanakura Y, Fukuhara S, Hino M, Kanamaru A, Ogawa H, Aozasa K.
  • Journal Title: Ann Hematol. 86 Pages: 557-564
  • Peer Reviewed
• [Journal Article] Thymoma-associated graft-versus-host disease-like erythroderma (2007)
  • Author(s): Nakagiri T, Okumura M, Inoue M, Minami M, Kiyohara E, Umegaki N, Nakamura T, Tomita Y, Katayama I, Aozasa K
  • Journal Title: J Thorac Oncol. 2 Pages: 1130-1132
  • Peer Reviewed
• [Journal Article] Abdominal Tuberculosis: peritoneal involvement shown by F-18 FDG PET (2007)
  • Author(s): Shimamoto H, Hamada K, Higuchi I, Tsujihata M, Nonomura N, Tomita Y, Okuyama A, Aozasa K, Hatazawa J
  • Journal Title: Clin Nucl Med. 32 Pages: 716-718
  • Peer Reviewed
• [Journal Article] 18F-FDG PET of Musculoskeletal Tumors: A Correlation with the Expression of Glucose Transporter 1 and Hexokinase II (2007)
  • Author(s): Hamada K, Tomita Y, Qiu Y, Zhang B, Ueda T, Myoui A, Higuchi I, Yoshikawa H, Aozasa K, Hatazawa J
  • Journal Title: Ann. Nuclear Med. 22 Pages: 699-705
  • NAID: 10024456619
  • Peer Reviewed
• [Journal Article] E74-like factor regulates Valosin-containing protein expression. (2007)
  • Author(s): Zhang B, Tomita Y, et. al.
  • Journal Title: Biochem. Biophys. Res. Commun. 356 Pages: 536-541
  • Peer Reviewed
• [Journal Article] Prognostic significance of CD100 expression in soft tissue sarcoma. (2007)
  • Author(s): Ch'ng ES, Tomita Y, et. al.
  • Journal Title: Cancer 110 Pages: 164-172
  • Peer Reviewed
• [Journal Article] Expression of Hepatoma-derived growth factor is correlated with tumor recurrence of esophageal carcinoma. (2007)
  • Author(s): Yamamoto S, Tomita Y, et. al.
  • Journal Title: Annals of Surgical Oncology 14 Pages: 2141-2149
  • Peer Reviewed
• [Journal Article] Prognostic significance of phosphorylated FOXO1 expression in soft tissue sarcoma
  • Author(s): Zhang B, Tomita YCh'ng E, Qiu Y, He J, Jin YF, Tomoeda M, Hamada K, Ueda T, Aozasa K
  • Journal Title: Ann. Surg. Oncol. (印刷中)
• [Journal Article] A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation
  • Author(s): Gotoh K, Yamada T, Ishikawa O, Takahashi H, Eguchi H, Yano M, Ohigashi H, Tomita Y, Miyamoto Y, Imaoka S
  • Journal Title: J Surg Oncol (印刷中)
• [Journal Article] Salivary duct carcinoma of the parotid gland: Clinical and MR features in six patients
  • Author(s): Kashiwagi N, Takashima S, Tomita Y, Araki Y, Yoshino K, Taniguchi S, Nakanishi K
  • Journal Title: Brit. J Radiol. (印刷中)
• [Journal Article] CD74 Is a Novel Prognostic Factor for Patients with Pancreatic Cancer Receiving Multimodal Therapy
  • Author(s): Nagata N, Jin YF, Yoshizato K, Tomoeda M, Song M, Iizuka N, Kitamura M, Takahashi H, Eguchi H, Ohigashi H, Ishikawa O,Tomita Y
  • Journal Title: Ann. Surg. Oncol. (印刷中)
• [Presentation] 肝、胆道系、膵臓の細胞診 良悪・診断のキーポイント 肝穿刺細胞診の細胞所見 高分化型肝細胞癌を中心に (2008)
  • Author(s): 竹中明美, 冨田裕彦, 他
  • Organizer: 第49回日本臨床細胞学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-07
• [Presentation] Carcinoid tumor occuring in the mediastinum (2008)
  • Author(s): Tomita Y, Jin YF, Ohta S, Ryu A, Takenaka A, Nakayama T, Imamura F, Higashiyama M, Kodama K
  • Organizer: 第47回日本臨床細胞学会秋期大会
• [Book] 解明 病理学 病気のメカニズムを解く 各論 第12章 乳腺 第16章 骨・軟部組織 (2009)
  • Author(s): 冨田裕彦著, 青笹克之編
  • Publisher: 医歯薬出版株式会社
• [Book] 解明 病理学 病気のメカニズムを解く各論 第12章 乳腺 第16章 骨・軟部組織 (2009)
  • Author(s): 冨田裕彦
  • Total Pages: 827
  • Publisher: 医歯薬出版株式会社