The roles of the common fragile site-related tumor suppressors in the process of development of human malignancies.

• Project/Area Number: 19590347
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kobe University
• Principal Investigator: SEMBA Shuho Kobe University, 大学院医学研究科, 准教授 (00302092)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: Fhit / Wwox / 口腔癌 / 膵臓癌 / Fhit遺伝子 / WWOX遺伝子 / がん抑制遺伝子 / 染色体脆弱部位 / Chk2 / Smad4

Research Abstract

がんは遺伝子の病気であり、染色体レベルでの欠失や転座が生じやすい部分には、『がん抑制遺伝子』と呼ばれる細胞のがん化を抑制している遺伝子が存在するのではという仮説がある。本研究は、染色体脆弱部位に存在するFragile histidine triad (FHIT)遺伝子、WW domain-containing oxidereductase (WWOX)遺伝子産物に注目し、その機能解析とヒト悪性腫瘍発生メカニズムについて各種検討を行った。

Research Products

• [Journal Article] Hypermethylation-mediated reduction of WWOX expression in intraductal papillary-mucinous neoplasms of the pancreas (2009)
  • Author(s): Nakayama S, Semba S, Maeda N, Matsushita M, Kuroda Y, Yokozaki H
  • Journal Title: Br J Cancer 100(9) Pages: 1438-1443
  • Peer Reviewed
• [Journal Article] Restoration of fragile histidine triad expression resotres Chk2 activity in response to ionizing radiation in oral squamous carcinoma cells (2008)
  • Author(s): Yutori H, Semba S, Komori T, Yokozaki H
  • Journal Title: Cancer Sci 99 Pages: 524-530
  • Peer Reviewed
• [Journal Article] Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells (2008)
  • Author(s): Nakayama S, Semba S, Maeda N, Aqeilan RI, Huebner K, Yokozaki H
  • Journal Title: Cancer Sci 9 Pages: 1370-1376
  • Peer Reviewed
• [Journal Article] Restoration of fragile histidine triad expression restores Chk2 activity inresponse to ionizing radiation in oral squamous cell carcinoma cells. (2008)
  • Author(s): Yutori H, Semba S, Komori T, Yokozaki H.
  • Journal Title: Cancer Science 99 Pages: 524-530
  • Peer Reviewed
• [Journal Article] Role of the wwox gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells. (2008)
  • Author(s): Nakayama S, Semba S, Maeda N, Aqeilan RI, Huebner K, Yokozaki H.
  • Journal Title: Cancer Science 99 Pages: 1370-1376
  • Peer Reviewed
• [Journal Article] Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells. (2008)
  • Author(s): Yutori H, Semba S, et. al.
  • Journal Title: Cancer Science 99 Pages: 524-530
  • Peer Reviewed
• [Journal Article] Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity (2007)
  • Author(s): Cantor JP, Iliopoulos D, Rao AS, Druck T, Semba S, Han SY, McCorkell KA, Lakshman TV, Collins JE, Wachsberger P, Friedberg JS, Huebner K
  • Journal Title: Int J Cancer 120 Pages: 24-31
  • Peer Reviewed
• [Journal Article] Increased wild-type p53-induced phos phatase-1 (Wip1 or PPM1D) expression correlated with downregulation of check point kinase 2 in human gastric carci noma (2007)
  • Author(s): Fuku T, Semba S, Yutori H, Yokozaki H
  • Journal Title: Pathol Int 57 Pages: 566-571
  • Peer Reviewed
• [Journal Article] Epigenetic modulation of endogenous tumor suppressor expression in lung c ancerxenografts suppresses tumorigenicity. (2007)
  • Author(s): Cantor JP, Semba S, et. al.
  • Journal Title: International Journal of Cancer 120 Pages: 24-31
  • Peer Reviewed
• [Journal Article] Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression.
  • Author(s): Mizuuchi E, Semba S, Kodama Y, Yokozaki H.
  • Journal Title: International Journal of Cancer (in press)(掲載確定)
  • Peer Reviewed
• [Presentation] PRL-3によるKeratin 8リン酸化制御を介した細胞述動能の解析 (2008)
  • Author(s): 仙波秀峰, 水内恵理, 横崎宏
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 大腸癌における癌抑制遺伝子WW domain containing oxidereductase (WWOX)の発現についての検討 (2008)
  • Author(s): 松下麻衣,中山俊二,仙波秀峰,横崎宏
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] 口腔扁平上皮癌細胞においてFHIT遺伝子の修復はDNA損傷応答におけるChk2の活動性を回復させる (2008)
  • Author(s): 柚鳥宏和,仙波秀峰,古森孝英,横崎宏
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] 浸潤性膵管癌、膵管内乳頭粘液性腫瘍における癌抑制遺伝子WWOXの発現の検討 (2008)
  • Author(s): 中山俊二,仙波秀峰,横崎宏
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
• [Presentation] がん抑制遺伝子NIT1遺伝子とFHIT遺伝子 : 染色体脆弱部位と発癌の関連について (2007)
  • Author(s): 仙波 秀峰
  • Organizer: 第96回 日本病理学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-03-13