Moleculo-Pathological studies on intracellular cross-talk signal in angiogenic and lymphoangiogenic process
| Project/Area Number |
19590352
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
NAKAGAWA Kazunori Kyushu University, 大学院・医学研究院, 講師 (50217668)
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| Co-Investigator(Kenkyū-buntansha) |
SUEISHI Katsuo 九州大学, 大学院・医学研究院, 教授 (70108710)
KOGA Takaomi 九州大学, 大学病院, 講師 (70380615)
OKANO Shinji 九州大学, 大学病院, 臨床助教 (10380429)
ONIMARU Mitsuho 九州大学, 大学院・医学研究院, 助教 (00380626)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 循環器 / 血管新生 / リンパ管 / 動脈硬化 / 内皮細胞 / VEGF / 川崎病 / 脈管新生 / シグナル伝達 / シェディング / ポドプラニン |
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| Research Abstract |
脈管(血管・リンパ管)新生での細胞間相互の情報伝達機構、細胞の機能変化、さらに脈管新生を基盤とする病態(血管新生病など)の解明と治療法の開発は極めて重要かつ緊急課題である。本研究では、動脈硬化、血管炎、血管新生病(腫瘍・糖尿病)あるいは臓器・組織虚血と側副血行路発達、リンパ管新生に関する分子病態の検討から、血管病変進展において脈管(血管・リンパ管)新生関連因シグナルが病態形成に中心的役割を果たしていることが明らかになった。
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Report
(3 results)
Research Products
(41 results)
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[Journal Article] Inhibition of nuclear translocation of apoptosis-inducing factor is essential mechamnism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration2008
Author(s)
Murakami Y, Ikeda Y, Yonemitsu Y, Onimaru M, Nakagawa K, Kohno R, Miyazaki M, Hisatomi T, Nakamura M, Yabe T, Hasegawa M, Ishibashi T, Sueishi K
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Journal Title
Am J Pathol 173(5)
Pages: 1326-38
Related Report
Peer Reviewed
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[Journal Article] Synergistic neuroprotective effect via simian lentiviral vector-mediated simultaneous gene transfer of human pigment epithelium-derived factor and human fibroblast growth factor-2 in rodent models of retinitis pigmentosa2008
Author(s)
Miyazaki M, Ikeda Y, Yonemitsu Y, Goto Y, Kohno RI, Murakami Y, Inoue M, Ueda Y, Hasegawa M, Tobimatsu S, Sueishi K, Ishibashi T
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Journal Title
J Gene Med 10(12)
Pages: 1273-81
Related Report
Peer Reviewed
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[Journal Article] A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction2007
Author(s)
Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y
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Journal Title
Nat Genet 39(2)
Pages: 212-217
Related Report
Peer Reviewed
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[Presentation] Regulation of mitochondrial release of apoptosis-inducing factor is a mechanism for neuroprotective activity of pigment epithelium-derived factor in retinal degeneration2008
Author(s)
Murakamia Y, Ikeda Y, Yonemitsu Y, Onimaru M, Nakagawa K, Kohno R, Miyazaki M, Nakamura M, Yabe T, Inoue M, Hasegawa M, Ishibashi T, Sueishi K
Organizer
ARVO 2008 Annual Meeting(78回)
Place of Presentation
Florida, U.S.A.
Related Report
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