The association and origin of tissue factor in deep venous thrombosis

• Project/Area Number: 19590356
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: University of Miyazaki
• Principal Investigator: 佐藤 勇一郎 University of Miyazaki, 医学部, 助教 (90347055)
• Co-Investigator(Kenkyū-buntansha): 丸塚 浩助 宮崎大学, 医学部, 准教授 (00239154) ; 畠山 金太 宮崎大学, 医学部, 講師 (60325735) ; 山下 篤 宮崎大学, 医学部, 助教 (90372797) ; 浅田 祐士郎 宮崎大学, 医学部, 教授 (70202588)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 循環器 / 静脈血栓症 / 組織因子 / 病理 / 深部静脈血栓症 / 肺血栓症 / 免疫染色 / 動物モデル

Research Abstract

ヒト静脈血栓症において組織因子の明らかな発現増加は認められず、動物実験においてもそその発現増加はなかった。

Research Products

• [Journal Article] Incidence of asymptomatic coronary thrombosis and plaque disruption : Comparison of non-cardiac and cardiac deathsamong autopsy cases (2009)
  • Author(s): Sato Y, Hatakeyama K, Marutsuka K, Asada Y.
  • Journal Title: Thromb Res 124 Pages: 19-23
• [Journal Article] Thioredoxin in coronary culprit lesions : Possible relationship to oxidative stress and intraplaque hemorrhage (2008)
  • Author(s): Nishihira K, Yamashita A, Imamura T, Hatakeyama K, Sato Y, Nakamura H, Yodoi J, Ogawa H, Kitamura K, Asada Y.
  • Journal Title: Atherosclerosis 201 Pages: 360-367
• [Journal Article] Thioredoxin in coronary culprit lesions : Possible relationship to oxidative stress and intraplaque hemorrhage. (2008)
  • Author(s): Nishihira K, Sato Y
  • Journal Title: Atherosclerosis 201 Pages: 360-367
  • Peer Reviewed
• [Journal Article] Hypereosinophilic syndrome associated with occlusive coronary thrombosis and right ventricular thrombus. (2008)
  • Author(s): Sato Y
  • Journal Title: Pathology International 58 Pages: 138-141
  • Peer Reviewed
• [Journal Article] Tissue factor pathway inhibitor is highly susceptible to chymase-mediated proteolysis (2007)
  • Author(s): Hamuro
  • Journal Title: FEBESJ 274 Pages: 3065-3077
  • Peer Reviewed
• [Journal Article] Expression of interleukin-18 in coronary plaque obtained by atherectomy from patients with stable and unstable angina. (2007)
  • Author(s): Nishihira
  • Journal Title: Thromb Res 121 Pages: 275-277
  • Peer Reviewed
• [Journal Article] Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome (2007)
  • Author(s): Miyoshi
  • Journal Title: Circulation 116 Pages: 1226-1233
  • Peer Reviewed
• [Presentation] 血液凝固因子XIは深部静脈血栓症に存在しトロンビン産生を介して血栓の成長に関与する (2008)
  • Author(s): 高橋良咲、山下篤、佐藤勇一郎、浅田祐士郎
  • Organizer: 第31回日本血栓止血学会学術集会
  • Place of Presentation: 大阪府大阪市
• [Presentation] 脳腫瘍血管の病理組織学的検討 (2008)
  • Author(s): 佐藤信也、佐藤勇一郎、丸塚浩助、浅田祐士郎
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 石川
• [Presentation] 血液凝固因子XIは深部静脈血栓症に存在しトロンビン産生を介して血栓の成長に関与する (2008)
  • Author(s): 高橋良咲, 佐藤勇一郎
  • Organizer: 第31回日本血栓止血学会学術集会
  • Place of Presentation: 大阪市
• [Presentation] 非心臓死剖検例における冠動脈血栓の病理組織学的検討 (2007)
  • Author(s): 佐藤 勇一郎
  • Organizer: 第39回日本動脈硬化学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-13
• [Remarks]
  • URL: http://www.med.miyazaki-u.ac.jp/pathol