Molecular pathology and classification of MALT lymphoma

• Project/Area Number: 19590359
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nagoya City University
• Principal Investigator: INAGAKI Hiroshi Nagoya City University, 大学院・医学研究科, 教授 (30232507)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: MALTリンパ腫 / 分子病理学 / 慢性炎症 / API2-MALT1キメラ遺伝子 / 前立腺原発MALTリンパ腫 / 皮膚辺縁帯リンパ腫 / 国際共同研究 / ボレリア感染 / 遺伝子メチル化 / 組織好酸球浸潤 / ピロリ菌 / 免疫グロブリン重鎖遺伝子 / 節性辺縁帯B細胞性リンパ腫 / 口腔原発MALTリンパ腫

Research Abstract

胃MALTリンパ腫の免疫グロブリン重鎖遺伝子解析から慢性炎症を基盤に発生するMALTリンパ腫群と慢性炎症の関与が明らかではない群は互いに独立していることを明らかにした。またアジア、欧州、米国間で共同研究を行い、皮膚辺縁帯B細胞リンパ腫は慢性炎症の関与が明らかではない群であること、DAPKおよびp16遺伝子メチル化が高率に認められること、またアジア症例には好酸球の浸潤が特徴的であること、を明らかにした。MALTリンパ腫全体像を最新成果とともに総説に著した。

Research Products

• [Journal Article] Primary mucosa-associated lymphoid tissue lymphoma of the prostate : Tumor relapse 7 years after local therapy (2008)
  • Author(s): Li C, Inagaki H (8名、8番目)
  • Journal Title: Pathol Int 58 Pages: 191-5
  • NAID: 10027376144
  • Peer Reviewed
• [Journal Article] Primary cutaneous marginal zone B-cell lymphoma : a molecular and clinicopathological study of cases from Asia, Germany, and the United States (2008)
  • Author(s): Takino H, Inagaki H (9名、9番目)
  • Journal Title: Mod Pathol 21 Pages: 1517-1526
  • Peer Reviewed
• [Journal Article] Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma (2008)
  • Author(s): Yano H, Inagaki H (17名、15番目)
  • Journal Title: Cancer Sci. 99 Pages: 2309-14
  • NAID: 10024013572
  • Peer Reviewed
• [Journal Article] Primary mucosa-associated lymphoid tissue lymphoma of the prostate : Tumor relapse 7 years after local therapy (2008)
  • Author(s): Li C, Inagaki H, et al.
  • Journal Title: Pathology International 58 Pages: 191-5
  • NAID: 10027376144
  • Peer Reviewed
• [Journal Article] Primary cutaneous marginal zone B-cell lymphoma : a molecular and clinicopathological study of cases from Asia, Germany, and the United States (2008)
  • Author(s): Takino H, Inagaki H, et al.
  • Journal Title: Modern Pathology 21 Pages: 1517-26
  • Peer Reviewed
• [Journal Article] Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma (2008)
  • Author(s): Yano H, Inagaki H, et al.
  • Journal Title: Cancer Science 99 Pages: 2309-14
  • NAID: 10024013572
  • Peer Reviewed
• [Journal Article] Primary mucosa-associated lymphoid tissue lymphoma of the prostate: Tumor relapse 7 years after local therapy (2008)
  • Author(s): Li C, Inagaki H, et. al.
  • Journal Title: Pathol Int 58 Pages: 191-5
  • NAID: 10027376144
  • Peer Reviewed
• [Journal Article] Immunoglobulin VH gene analysis in gastric MALT lymphomas (2007)
  • Author(s): Sakuma H, Inagaki H (12名、12番目)
  • Journal Title: Mod Pathol 20 Pages: 460-6
  • Peer Reviewed
• [Journal Article] Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma (2007)
  • Author(s): Li C, Inagaki H (11名、11番目)
  • Journal Title: Mod Pathol 20 Pages: 648-55
  • Peer Reviewed
• [Journal Article] Clinical implications of nodal marginal zone B-cell lymphoma among Japanese : study of 65 cases (2007)
  • Author(s): Kojima M, Inagaki H (8名、2番目)
  • Journal Title: Cancer Sci 98 Pages: 44-9
  • Peer Reviewed
• [Journal Article] Defucosylated anti CC chemokine receptor 4 monoclonal antibody combined with immunomodulatory cytokines : a novel immunotherapy for aggressive/refractory Mycosis fungoides and Sezary syndrome (2007)
  • Author(s): Yano H, Inagaki H (10名、9番目)
  • Journal Title: Clin Cancer Res. 13 Pages: 6494-500
  • Peer Reviewed
• [Journal Article] Histopathological Variation of Primary Mucosa-associated Lymphoid Tissue Lymphoma of the Oral Cavity (2007)
  • Author(s): Kojima M, Inagaki H (10名、10番目)
  • Journal Title: Pathol Oncol Res. 13 Pages: 345-9
  • Peer Reviewed
• [Journal Article] Mucosa-associated lymphoid tissue lymphoma : molecular pathogenesis and clinicopathological significance (2007)
  • Author(s): Inagaki H (単著)
  • Journal Title: Pathol Int 57 Pages: 474-84
  • NAID: 10021233370
  • Peer Reviewed
• [Journal Article] Immunoglobulin VH gene analysis in gastric MALT lymphomas (2007)
  • Author(s): Sakuma H, Inagaki H, et. al.
  • Journal Title: Mod Pathol 20 Pages: 460-6
  • Peer Reviewed
• [Journal Article] Clinical implications of nodal marginal zone B-cell lymphoma among Japanese: study of 65 cases (2007)
  • Author(s): Kojima M, Inagaki H, et. al.
  • Journal Title: Cancer Sci 98 Pages: 44-9
  • Peer Reviewed
• [Journal Article] Histopathological Variation of Primary Mucosa-associated Lymphoid Tissue Lymphoma of the Oral Cavity (2007)
  • Author(s): Kojima M, Inagaki H, et. al.
  • Journal Title: Pathol Oncol Res 13 Pages: 345-9
  • Peer Reviewed
• [Journal Article] Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma (2007)
  • Author(s): Li C, Inagaki H, et. al.
  • Journal Title: Mod Pathol 20 Pages: 648-55
  • Peer Reviewed
• [Journal Article] Defucosylated anti CC chemokine receptor 4 monoclonal antibody combined with immunomodulatory cytokines: a novel immunotherapy for aggressive/refractory Mycosis fungoides and Sezary syndrome (2007)
  • Author(s): Yano H, Inagaki H, et. al.
  • Journal Title: Clin Cancer Res 13 Pages: 6494-500
  • Peer Reviewed
• [Journal Article] Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rγnull mouse model
  • Author(s): Ito A, Inagaki H(14名、13番目)
  • Journal Title: Cancer Immunology and Immunotherapy (印刷中)
  • Peer Reviewed
• [Journal Article] Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rγnull mouse model.
  • Author(s): Ito A, Inagaki H, et al.
  • Journal Title: Cancer Immunology and Immunotherapy (印刷中)
  • Peer Reviewed
• [Presentation] 14q32転座関連遺伝子mRNA発現に基づく病型分類は骨髄腫患者の生命予後予測に有用である (2008)
  • Author(s): 稲垣淳、稲垣宏、他
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] 陰嚢腫大により発見されたマントル細胞リンパ腫の1例 (2008)
  • Author(s): 田中健太郎、稲垣宏、他
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 皮膚B細胞リンパ腫における遺伝子メチル化についての分子病理学的検索 (2007)
  • Author(s): 滝野寿, 稲垣宏, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-03-14
• [Presentation] 胃MALTリンパ腫における免疫グロブリン重鎖可変領域解析 (2007)
  • Author(s): 佐久間英則, 稲垣宏, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-03-14
• [Presentation] 胸腺MALTリンパ腫における腫瘍関連遺伝子の過剰メチル化解析 (2007)
  • Author(s): 李春梅, 稲垣宏, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-03-14
• [Presentation] MECT1-MAML2キメラ遺伝子陽性唾液腺粘表皮癌の組織学的特徴についての検討 (2007)
  • Author(s): 岡部光邦, 稲垣宏, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-03-14
• [Presentation] 唾液腺粘表皮癌における遺伝子メチル化についての分子病理学的検討 (2007)
  • Author(s): 宮部悟, 稲垣宏, 他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-03-14
• [Presentation] CCR4を分子標的とするMycosis fungoides/Sezary syndromeに対する新規抗体療法 (2007)
  • Author(s): 矢野寛樹、稲垣宏、他
  • Organizer: 第69回日本血液学会総会
  • Place of Presentation: 横浜
• [Presentation] ボルテゾミブ治療中に傍脊椎、皮膚、および上縦隔腫瘤として髄外再発をきたした多発性骨髄腫の1例 (2007)
  • Author(s): 楠本茂、稲垣宏、他
  • Organizer: 第69回日本血液学会総会
  • Place of Presentation: 横浜
• [Presentation] 血清Free Light Chainを測定した非分泌型多発性骨髄腫の2例 (2007)
  • Author(s): 伊藤旭、稲垣宏、他
  • Organizer: 第69回日本血液学会総会
  • Place of Presentation: 横浜
• [Presentation] 胸腺MALTリンパ腫における遺伝子過剰メチル化とFas遺伝子異常 (2007)
  • Author(s): 李春梅、稲垣宏、他
  • Organizer: 第47回日本リンパ網内系学会総会
  • Place of Presentation: 淡路
• [Presentation] 皮膚辺縁帯B細胞リンパ腫における遺伝子過剰メチル化 (2007)
  • Author(s): 滝野寿、稲垣宏、他
  • Organizer: 第47回日本リンパ網内系学会総会
  • Place of Presentation: 淡路
• [Presentation] Relapsed adult T-cell leukemia/lymphoma limited in the skin after allogeneic stem cell transplantation (2007)
  • Author(s): Kusumoto S, Inagaki H, et.al.
  • Organizer: The 13th International Conference on Human Retrovirology
  • Place of Presentation: Hakone, Japan
• [Presentation] 皮膚B細胞リンパ腫における遺伝子メチル化についての分子病理学的検索 (2007)
  • Author(s): 滝野寿、稲垣宏、他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] 胃MALTリンパ腫における免疫グロブリン重鎖可変領域解析 (2007)
  • Author(s): 佐久間英規、稲垣宏、他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] 胸腺MALTリンパ腫における腫瘍関連遺伝子の過剰メチル化解析 (2007)
  • Author(s): 李春梅、稲垣宏、他
  • Organizer: 第96回日本病理学会総会
  • Place of Presentation: 大阪
• [Presentation] Molecular pathogenesis of MALT lymphoma : MALT lymphoma and API2-MALT1 fusion (2007)
  • Author(s): Inagaki H.
  • Organizer: The 6th Japan-China-Korea Joint Conference on Helicobacter Infection
  • Place of Presentation: Busan Korea
• [Remarks]
  • URL: http://www.med.nagoya-cu.ac.jp/patho2.dir/index.htm
• [Remarks]
  • URL: http://www.med.nagoya-cu.ac.jp/patho2.dir/index.htm