Study on tumor location and progression of prostate cancer by three- dimensional analysis

• Project/Area Number: 19590361
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nara Medical University
• Principal Investigator: ISHIDA Eiwa Nara Medical University, 医学部, 助教 (10332967)
• Co-Investigator(Kenkyū-buntansha): KONISHI Noboru 奈良県立医科大学, 医学部, 教授 (20145832)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: prostate cancer / three-dimensional analysis / DNA microarray / PIN / ductal spreading

Research Abstract

前立腺癌は組織内に様々の形態の腫瘍が発生したり、多発性に生ずることが多い。三次元構築ソフトウエアによって腫瘍間の連続性・非連続性を検討した上で、この差異が遺伝子的に説明しうるかをDNAマイクロアレイ法で解析したところ、候補遺伝子群が認められた。これらの遺伝子群の中に術前に得られた生検標本から多発性であるか否かを予測できるマーカー遺伝子が存在する可能性があると考えられた。

Research Products

• [Journal Article] Immunohistochemical analysis of neuroendocrine differentiation in prostate cancer (2009)
  • Author(s): Ishida, E., Nakamura, M., Shimada, K., Tasaki, M., Konishi, N.
  • Journal Title: Pathobiology Vol.76 Pages: 30-38
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of neuroendocrine differentiation in prostate cancer (2009)
  • Author(s): Ishida, E., Nakamura, M., Konishi, N., et al
  • Journal Title: Pathobiology 76 Pages: 30-38
  • Peer Reviewed
• [Journal Article] HRK inactivation associated with promoter methylation and LOH in prostate cancer (2008)
  • Author(s): Higuchi, T., Nakamura, M., Shimada, K., Ishida, E., Hirao, K., Konishi, N.
  • Journal Title: Prostate Vol.68(1) Pages: 105-113
  • Peer Reviewed
• [Journal Article] Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer (2008)
  • Author(s): Shimada, K., Nakamura, M., Ishida, E., Higuchi, T., Yamamoto, H., Tsujikawa, K., Konishi, N.
  • Journal Title: Cancer Sci Vol.99 Pages: 39-45
  • NAID: 10024000834
  • Peer Reviewed
• [Journal Article] Function of JunB in transient amplifying cell senescence and progression of human prostate cancer (2008)
  • Author(s): Konishi, N., Shimada, K., Nakamura, M., Ishida, E., Ota, I., Tanaka, N., Fujimoto, K.
  • Journal Title: Clin Cancer Res Vol.14(14) Pages: 4408-4416
  • Peer Reviewed
• [Journal Article] HRK inactivation associated with promoter methylation and LOH in prostate cancer (2008)
  • Author(s): Higuchi, T., Ishida, E., Konishi, N., et al
  • Journal Title: Prostate 68 Pages: 105-113
  • Peer Reviewed
• [Journal Article] Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer (2008)
  • Author(s): Shimada, K., Ishida, E., Konishi, N., et al
  • Journal Title: Cancer Science Vol. 99 : 39-45 99 Pages: 39-45
  • NAID: 10024000834
  • Peer Reviewed
• [Journal Article] Function of JunB in transient amplifying cell senescence and progression of human prostate cancer (2008)
  • Author(s): Konishi, N., Shimada, K., Ishida, E., et al
  • Journal Title: Clinical Cancer Research 14 Pages: 4408-4416
  • Peer Reviewed
• [Journal Article] HRK inactivation associated with promoter methylation and LOH inprostate cancer (2008)
  • Author(s): Higuchi T, Nakamura M, Shimada K, Ishida E, Konishi N, et. al.
  • Journal Title: Prostate 68 Pages: 105-113
  • Peer Reviewed
• [Journal Article] Postate cancer antigen-1 contributes to cell survival and invasionthough discoidin receptor 1 in human prostate cancer (2008)
  • Author(s): Shimada K, Nakamura M, Ishida E, Konishi N, et. al.
  • Journal Title: Cancer Sci 99 Pages: 39-45
  • Peer Reviewed
• [Journal Article] DNA hypermethylation status of multiple genes in papillary thyroid carcinomas (2007)
  • Author(s): Ishida, E., Nakamura, M., Shimada, K., Higuchi, T., Takatsu, K., Yane, K., Konishi, N.
  • Journal Title: Pathobiology Vol.74 Pages: 344-352
  • Peer Reviewed
• [Journal Article] c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas (2007)
  • Author(s): Shimada, K., Nakamura, M., Ishida, E., Higuchi, T., Tanaka, M., Ota, I., Konishi, N.
  • Journal Title: Am J Pathol Vol.171(3) Pages: 1003-1012
  • Peer Reviewed
• [Journal Article] Fatal cytomegalovirus-associated adrenal insufficiency in an AIDS patient receiving corticosteroid therapy (2007)
  • Author(s): Uno, K., Konishi, M., Yoshimoto, E., Kasahara, K., Mori, K., Maeda, K., Ishida, E., Konishi, N., Murakawa, K., Mikasa, K.
  • Journal Title: Inern Med Vol.46(9) Pages: 617-620
  • NAID: 130000078725
  • Peer Reviewed
• [Journal Article] Molecular pathogenesis of pediatric astrocytic tumors (2007)
  • Author(s): Nakamura, M., Shimada, K., Ishida, E., Higuchi, T., Nakase, H., Sakaki, T., Konishi, N.
  • Journal Title: Neuro-Oncol Vol.9(2) Pages: 113-123
  • Peer Reviewed
• [Journal Article] Genetic analysis to complement histopathological diagnosis of brain tumors (2007)
  • Author(s): Nakamura, M., Shimada, K., Ishida, E. Nakase, H., Konishi, N.
  • Journal Title: Histol Histopathol Vol.22 Pages: 327-335
  • Peer Reviewed
• [Journal Article] DNA hypermethylation status of multiple genes in papillary thyroidcarcinoma (2007)
  • Author(s): Ishida E, Nakamura M, Yane K, Konishi N, et. al.
  • Journal Title: Pathobiology 74 Pages: 344-352
  • Peer Reviewed
• [Journal Article] c-Jun NH2 termonal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothehal carcionoma (2007)
  • Author(s): Shimada K, Nakamura M, Ishida E, Konishi N, et. al.
  • Journal Title: Am J Pathol 171 Pages: 1003-12
  • Peer Reviewed
• [Journal Article] Ftal cytomegalovirus-associated adrenal insufficiency in AIDS patientreceiving cortioosteroid therapy (2007)
  • Author(s): Uno K, Konishi M, Yoshimoto E, Kasahara K, Mori K, Maeda K, Ishida E, et. al.
  • Journal Title: Intern Med 46 Pages: 617-20
  • Peer Reviewed
• [Journal Article] Molecular pathogenesis of pediatric astrocytic tumors (2007)
  • Author(s): Nakamura M, Shimada K, Ishida E, Konishi N, et. al.
  • Journal Title: Neuro-Oncol 9 Pages: 113-23
  • Peer Reviewed
• [Journal Article] Genetic analysis to complement histopathological diagnosis of braintumors (2007)
  • Author(s): Nakamura M, Shimada K, Ishida E, Konishi N, et. al.
  • Journal Title: Histol Histopathol 22 Pages: 327-35
  • Peer Reviewed
• [Presentation] DNA microarray analysis of multicentric prostate cancer based on the computer-assisted three-dimensional model (2008)
  • Author(s): Ishida, E., Nakamura, M., Shimada, K., Tasaki, M., Konishi, N.
  • Organizer: 第67回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] 前立腺癌 Gleason gradeにおける分子マーカーの検討 (2008)
  • Author(s): 石田英和、中村光利、島田啓司、樋口智紀、小西登
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-16
• [Presentation] 前立腺癌Gleason grade における分子マーカーの検討 (2008)
  • Author(s): 石田英和, 小西 登, 他
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-16
• [Presentation] 前立腺progenitor cellの生物学的特性と病理組織学的意義について (2008)
  • Author(s): 島田啓司、中村光利、石田英和、樋口智紀、小西登
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-15
• [Presentation] 前立腺progenitor cell の生物学的特性と病理組織学的意義について (2008)
  • Author(s): 島田啓司, 石田英和, 小西登, 他
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-15
• [Presentation] 前立腺癌新規遺伝子PCA-1の機能解析 (2008)
  • Author(s): 樋口智紀、島田啓司、石田英和、中村光利、小西登
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
• [Presentation] 前立腺癌における神経内分泌分化の検討 (2007)
  • Author(s): 石田英和、中村光利、島田啓司、樋口智紀、小西登
  • Organizer: 第66回 日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] 前立腺癌における神経内分泌分化の検討 (2007)
  • Author(s): 石田 英和、中村 光利、島田 啓司、樋口 智紀、松吉 修一、小西 登
  • Organizer: 第66回日本癌学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
• [Presentation] 前立腺癌 Gleason gradeにおける分子マーカーの検討 (2007)
  • Author(s): 石田英和、中村光利、島田啓司、樋口智紀、小西登
  • Organizer: 第18回 前立腺がんワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2007-09-28
• [Presentation] 前立腺癌Gleason gradeにおける分子マーカーの検討 (2007)
  • Author(s): 石田 英和、中村 光利、島田 啓司、樋口 智紀、小西 登
  • Organizer: 第18回前立腺がんワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2007-09-28