• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Histopathological analyses of stromal and vessel invasion in the gastrointestinal cancer.

Research Project

Project/Area Number 19590368
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionToho University

Principal Investigator

ISHIKAWA Yukio  Toho University, 医学部, 准教授 (30276894)

Co-Investigator(Kenkyū-buntansha) ISHII Toshiharu  東邦大学, 医学部, 教授 (30101893)
ITO Kinji  東邦大学, 医学部, 准教授 (40057758)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsリンパ管 / 脈管侵襲 / 胃癌 / 結腸癌 / LYVE-1抗体 / 接着因子 / MMP
Research Abstract

胃癌・結腸癌において、間質浸潤及び脈管侵襲に関与する蛋白の癌細胞発現を検討し、さらに血管とリンパ管の内皮細胞に特異的なマーカー(vWF抗体及びLYVE-1抗体)を用いて、客観的に脈管識別を行った上でリンパ管侵襲とリンパ節転移の関連を組織学的に解析した。胃癌では、癌先進部におけるclaudin-3, claudin-4, β-catenin, MMP-1, MMP-2の発現の内、MMP-1発現程度のみがリンパ節転移と有意な関連を示し、癌細胞の接着因子よりも間質浸潤能が脈管侵襲や転移に強く関与していることが示唆された。また、結腸癌では、癌先進部の腫瘍型の性状が、リンパ節転移に強く関わっていた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] Significance of lymphatic invasion and cancer invasion-relating proteins on lymph node metastasis in gastric cancer2009

    • Author(s)
      Kamata I, Ishikawa Y, Akishima-Fukasawa Y, Ito K, Akasaka Y, Uzuki M, Fujimoto A, Morita H, Tamai S, Maehara T, Ogata K, Shimokawa R, Igarashi Y, Miki K, Ishii T
    • Journal Title

      J Gastroenterol Hepatol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological predictor for regional lymph node metastasis in gastric cancer2009

    • Author(s)
      Morita H, Ishikawa Y, Akishima-Fukawasa Y, Ito K, Akasaka Y, Nishimura C, Igarashi Y, Miki K, Ishii T
    • Journal Title

      Virchows Arch 454

      Pages: 143-151

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathologioal predictor for regional lymph node Metastasis in gastric cancer.2009

    • Author(s)
      Morita H, Ishikawa Y, Et al.
    • Journal Title

      Virchows Arch 454

      Pages: 143-151

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of lymphatic invasion and cancer invasion-Relating proteins on lymph node metastasis in gastric-2009

    • Author(s)
      Kamata I, Ishikawa Y, At al.
    • Journal Title

      J Gastroenterol Hepatol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] and the Toho Study Group for Cancer Biological Behavior2008

    • Author(s)
      Ishikawa Y, Akishima-Fukasawa Y, Ito K, Akasaka Y, Yokoo T, Ishii T
    • Journal Title

      Histopathological determinants of regional lymph node metastasis in early colorectal cancer. Cancer 112

      Pages: 924-933

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathologic determinants of regional lymph node metastasis in early2008

    • Author(s)
      Yukio Ishikawa, et. al.
    • Journal Title

      Cancer 112

      Pages: 924-933

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] LYVE-1抗体、細胞接着因子・MMP抗体を用いた免疫組織化学による胃癌のリンパ節転移の組織学的規定因子。2008

    • Author(s)
      鎌田至, 石川由起雄, 森田宏伊藤金次, 赤坂喜清, 他
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] LYVE-1抗体、細胞接着因子・MMP抗体を用いた免疫組織化学による胃癌のリンパ節転移の組織学的規定因子2008

    • Author(s)
      鎌田至、石川由起雄、森田宏、伊藤金次、赤坂喜清、五十嵐良典、三木一正、石井壽晴
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県立音楽堂
    • Related Report
      2008 Final Research Report
  • [Presentation] LYVE-1抗体を使用した早期結腸癌のリンパ節転移の組織学的規定因子2008

    • Author(s)
      石川由起雄、秋嶋-深澤由里、伊藤金次、山崎一人、下川伶子、藤原美恵子、鈴木高祐、一瀬晃洋、木口英子、緒方謙太郎、新野史、海老原善郎
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川県立音楽堂
    • Related Report
      2008 Final Research Report
  • [Presentation] LYVE-1抗体を用いた胃癌における所属リンパ節転移の組織学的規定因子2007

    • Author(s)
      森田宏、三木一正、石川由起雄、伊藤金次、赤坂喜清、石井壽晴
    • Organizer
      第61回東邦医学会総会
    • Place of Presentation
      東邦大学医学部5号館地下第1講義室
    • Related Report
      2008 Final Research Report
  • [Presentation] Predictors for regional lymph node metastasis in gastric cancer through immunohistochemistry using LYVE-1 antibody combined with cell-adhesion proteins and matrix metalloproteinases antibodies.2007

    • Author(s)
      Kamata I, Ishikawa Y, Morita H, Ito K, Akasaka Y, Igarashi Y, Miki K, Ishii T
    • Organizer
      15^<th> United European Gastroenterology Week "UEGW" 2007
    • Place of Presentation
      Palais des Congres de Paris
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi