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Analysis of activation mechanism of HMGA2 gene and its regulating gene-pathways in the progression of lung cancer

Research Project

Project/Area Number 19590370
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKanazawa Medical University

Principal Investigator

UEDA Yoshimichi  Kanazawa Medical University, 医学部, 教授 (50271375)

Co-Investigator(Kenkyū-buntansha) SAGAWA Motoyasu  金沢医科大学, 医学部, 教授 (70292274)
Co-Investigator(Renkei-kenkyūsha) SHIMAZAKI Miyako  金沢医科大学, 医学部, 助教 (00440511)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords肺癌 / 扁平上皮癌 / HMGA2 / 上皮間質転換 / 浸潤・転移 / TGFβ / プラコグロビン / Laser captured microddisection / 上皮間質転換 EMT / EMT / Snail / cDNA array
Research Abstract

浸潤性肺扁平上皮癌細胞の上皮間質転換における HMGA2の関与を蛋白ならびに mRNAレベルで示すと共に、HMGA2発現誘導における TGFβ系シグナルの関与とHMGA2発現扁平上皮癌細胞における発現低下遺伝子群( E-cadhelin、Plakoglobin、zonula-occuludens 1(zo-1)、GSK3)、発現亢進遺伝子群(N-cadhelin、Smad4、Snail、cyclin D1、MMP-3、MMP-14、Jagged-1、Ezrin、Aquaporin-5)を選別・検証した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] Combined evaluation of preoperative FDG uptake on PET, GGO components on CT, and serum CEA Level: Identification of both low and high risk for recurrence in patients with resected T1 lung adenocarcinoma.2009

    • Author(s)
      Kotaro Higashi, Tsutomu Sakuma, Kengo Ito, Seiji Niho, Yoshimichi Ueda, Takeshi, Kobayashi, Ryuzo Sekiguchi, Tomoko Takahashi, Takashi Kato, Hisao Tonami.
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging 36

      Pages: 373-381

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combined Evaluation of Preoperative FDG Uptake on PET, GGO Componentson CT, and Serum CEA Level : Identification of Both Low and High Risk for Recurrence in Patients with Resected T1 Lung Adenocarcinoma.2009

    • Author(s)
      Kotaro Higashi
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging 36

      Pages: 373-381

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down regulation of plakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis.2008

    • Author(s)
      Yoshimitsu Kanazawa, Yoshimichi Ueda, Miyako Shimasaki, Shogo Katsuda, Norio Yamamto, Katsuo Tomita,Hiroyuki Tsuchiya.
    • Journal Title

      Anticancer Res 28

      Pages: 655-664

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel genes involved in the synergistic antitumor effect of caffeine in osteosarcoma cells using cDNA macroarray.2008

    • Author(s)
      Sadao Ii, Yoshimichi Ueda, Miyako Shimasaki, Shogo Katsuta, Koutarou Takazawa, Yoshimitsu Kanazawa, Katsuro Tomita, Hiroyuki Tsyuchiya.
    • Journal Title

      Anticancer Res 28

      Pages: 645-53

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肺癌病理の Up to Date2008

    • Author(s)
      上田 善道、島崎 都、東 光太郎、Giafei Guo 、佐藤 勝明、佐川 元保、佐久間 勉、勝田 省吾
    • Journal Title

      金沢医大雑誌 21

      Pages: 21-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肺癌病理のUp to Date2008

    • Author(s)
      上田 善道
    • Journal Title

      金沢医科大学雑誌 21

      Pages: 21-31

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Down regulation of plakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis.2008

    • Author(s)
      Yoshimitsu Kanazawa
    • Organizer
      The 8^<th> International Conference of Anticancer Research
    • Place of Presentation
      Kos in Greece
    • Year and Date
      2008-10-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Down regulation of plakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis.2008

    • Author(s)
      Yoshimitsu Kanazawa , Yoshimichi Ueda , Miyako Shimasaki, Shogo Katsuda, Norio Yamamto, Katsuo Tomita,Hiroyuki Tsuchiya
    • Organizer
      The 8^<th>International Conference of Anticancer Research
    • Place of Presentation
      in Kos, Greece
    • Related Report
      2008 Final Research Report
  • [Presentation] Identific-ation of Novel Genes Involved in the Synergistic Antitumor Effect of Caffeine in Osteosarcoma Cells Using cDNA Macroarray.2008

    • Author(s)
      Sadao Ii, Yoshimichi Ueda, Miyako Shimasaki, Shogo Katsuta, Koutarou Takazawa, Yoshimitsu Kanazawa, Katsuro Tomita, Hiroyuki Tsyuchiya
    • Organizer
      The 8^<th>International Conference of Anticancer Research
    • Place of Presentation
      in Kos, Greece
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression analysis for the identificationof genes involved in acquired resistance to cisplatin in osteosarcoma cells.2008

    • Author(s)
      Koutarou Takazawa, Hiroyuki Tsuchiya, Ueda Yoshimichi, Yoshimitsu Kanazawa, Sadao Ii, Katsuro Tomita
    • Organizer
      The 8^<th>International Conference of Anticancer Research
    • Place of Presentation
      in Kos, Greece
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒト軟部肉腫における新規肺転移抑制遺伝子human plakoglobin遺伝子の同定2008

    • Author(s)
      島崎 都、上田善道、佐藤勝明、勝田省吾
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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