Role of sodium/calcium ion exchanger expressed in macrophages in atherogenesis
| Project/Area Number |
19590372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Fukuoka University |
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Principal Investigator |
SAKATA Noriyuki Fukuoka University, 医学部, 教授 (20134273)
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| Co-Investigator(Kenkyū-buntansha) |
岩本 隆宏 福岡大学, 医学部, 教授 (20300973)
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| Co-Investigator(Renkei-kenkyūsha) |
IWAMOTO Takahiro 福岡大学, 医学部, 教授 (20300973)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 粥状硬化 / マクロファージ / Na+ / Ca2+交換体 / マトリックスメタロプロテアーゼ / プラーク破裂 / 血行力学的因子 / 有限要素法 / 内圧負荷 / 応力-ひずみ曲線 / トポグラフィー / 内膜剥離術 / 頚動脈内膜剥離術 / 症候性プラーク |
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| Research Abstract |
To clarify the mechanism which is responsible for the plaquerupture, we investigated the expression of sodium/calcium ion exchanger and matrix metalloproteinase and the stress/strain distribution in the human carotid arterial wall. Activated macrophages in fibrous cap expressed sodium/calcium ion exchanger-1 and matrix metalloproteinases-2 and 9 in atherosclerotic plaques. Therefore, these cells may contribute to the thinning and disruption of fibrous cap in the plaque. In addition, the concentration of the maximal principal stress is likely to trigger the plaque rupture.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-mathyl-D-aspartate injection and ischemia-reperfusion.2009
Author(s)
nokuti Y, Shimazawa M, Nakajima Y, Komuro I, Matsuda T, Baba A, Araie M, Kita S, Iwamoto T, Hara H
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Journal Title
J Neurosci Res 87
Pages: 906-917
Related Report
Peer Reviewed
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[Journal Article] Crystalization and preliminary X-ray crystallographic analysis of Ca2+-free primary Ca2+-sensor of Na+/Ca2+ exchanger.2008
Author(s)
Mima M, Kawai C, Paku K, Tomoo K, Ishida T, Sugiyama S, Matsumura H, Kitatani T, Yoshikawa HY, Maki S, Adachi H, Takano K, Murakami S, Inoue T, Mori Y, Kita S, Iwamoto T.
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Journal Title
Acta Crystallogr Sect F Struct Biol Cryst Commun 64
Pages: 1125-1127
Related Report
Peer Reviewed
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