Analysis of EGFR and KRAS gene mutation in the early developmental phase of lung adenocarcinoma

• Project/Area Number: 19590379
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: YATABE Yasushi Aichi Cancer Center Research Institute, 分子腫瘍学部, 研究員 (90280809)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 呼吸器 / 肺癌 / 腺癌 / KRAS / EGFR / 前癌病変 / 臓器特異性 / 肺がん / EGFR遺伝子 / KRAS遺伝子変異 / すりガラス様陰影 / 上皮内癌 / 早期癌

Research Abstract

多くの腫瘍は、前癌病変→上皮内癌→微小浸潤癌→浸潤癌と多段階の発癌過程を経ると考えられている。肺腺癌も同様であり、前癌病変に相当する病変として、異型腺腫様過形成があげられる。異型腺腫様過形成は偶発的に見出されることがほとんどで、遺伝子検索が容易に行える凍結組織が得られることはほとんどない。また、5mm以下の小さな病変であることから、遺伝子変異の検討が進んでいないのが現状である。そこで、本研究に先だって現在解析可能なサンプルを用いて、簡便に遺伝子変異の検討を可能にする系を確立した(J Mol Diagn 2006)。この方法を用いて、肺腺癌における前癌病変についての遺伝子変異解析を包括的に行った。これまでの報告でも類を見ない多数例となる異型腺腫様過形成 50例、上皮内癌50例、早期浸潤癌30例についての解析を行った。その結果、それぞれの段階の腫瘍間を比較すると、異型腺腫様過形成ではKRASの頻度が有意に高く、上皮内癌にはEGFR遺伝子変異が高い傾向があることが判明した。すでに報告しているように(J Pathol 2004)、浸潤癌ではKRAS遺伝子変異頻度が低いことから、異型腺腫様過形成が浸潤癌に進展すると考えると矛盾が生じる。そこで2つの知見を説明するには次の仮説が導き出された。すなわちKRAS遺伝子変異を有する異型腺腫様過形成はもはやそれ以上進展しない病変である可能性である。また、異型腺腫様過形成という病変は同じであっても、EGFR遺伝子変異を有する場合は上皮内癌から、さらには浸潤癌と浸潤する可能性が示唆された。これらの結果は、遺伝子改変マウスを用いた実験系の結果とよく一致する。また、この結果を用いて、現在臨床上問題となっている孤立性すりガラス様陰影の治療方針決定について遺伝子検査を導入することによってその判断の目安となる可能性が示唆された。

Research Products

• [Journal Article] Decreased risk of colorectal cancer with the high Natural-Killer (NK)-cell activity NKG2D genotype in Japanese (2008)
  • Author(s): Furue H, Matsuo K, Kumimoto H, Hiraki A, Suzuki T, Yatabe Y, Komori K, Kanemitsu Y. Hirai T, Kato T, Ueda M, Ishizaki K, Tajima K
  • Journal Title: Carcinogenesis 29 Pages: 316-320
• [Journal Article] Identifying patients with peripheral-type early non-small cell lung cancer (T1N0M0) for whom irradiation of the primary focus alone could lead to successful treatment (2008)
  • Author(s): Fuwa N, Daimon T, Mitsudomi T, Yatabe Y, Kodaira T, Tachibana H, Nakamura T, Kato T. Sato Y
  • Journal Title: Br J Radiol 81 Pages: 815-820
• [Journal Article] Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity (2008)
  • Author(s): Hara M, Nakanishi H, Tsujimura K, Matsui M, Yatabe Y, Manabe T, Tatematsu M
  • Journal Title: Cancer Sci 99 Pages: 1471-1478
  • NAID: 10024009000
• [Journal Article] Coincidence of mammary and sentinel lymph node papilloma (2008)
  • Author(s): Ichihara S, Ikeda T, Kimura K, Hanatate F, Yamada F, Hasegawa M, Moritani S, Yatabe Y
  • Journal Title: Am J Surg Pathol 32 Pages: 784-792
• [Journal Article] Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese (2008)
  • Author(s): Matsuo K, Hiraki A, Ito H, Kosaka T, Suzuki T, Hirose K, Wakai K, Yatabe Y, Mitsudomi T, Tajima K
  • Journal Title: Cancer Sci 99 Pages: 1202-1208
  • NAID: 10024007506
• [Journal Article] Sarcomatoid carcinoma of the thymus ansing in metaplastic thymoma (2008)
  • Author(s): Moritani S, Ichihara S, Mukai K, Seki Y, Inoue S, Yasuda A, Hakiri S, Yatabe Y, Eimoto T
  • Journal Title: Histopathology 52 Pages: 409-411
• [Journal Article] Clinical Features and Prognosis of Gastric MALT Lymphoma With Special Reference to Responsiveness to H. pylori Eradication and API2-MALTI Status (2008)
  • Author(s): Nakamura T, Seto M, Tajika M, Kawai H, Yokoi T, Yatabe Y, Nakamura S
  • Journal Title: Am J Gastroenterol 103 Pages: 62-70
• [Journal Article] Stepwise examination for differential diagnosis of primary lung cancer and breast cancer relapse presenting as a solitary pulmonary nodule in patients after mastectomy (2008)
  • Author(s): Okasaka T, Usami N, Mitsudomi T, Yatabe Y, Matsuo K, Yokoi K
  • Journal Title: J Surg Oncol 98 Pages: 510-514
• [Journal Article] Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer (2008)
  • Author(s): Osada H, Tomida S, Yatabe Y, Tatematsu Y, Takeuchi T, Murakami H, Kondo Y, Sekido Y, Takahashi T
  • Journal Title: Cancer Res 68 Pages: 1647-1655
• [Journal Article] Subcategonzation of lung cancer based on tumor size and degree of visceral pleural invasion (2008)
  • Author(s): Sakakura N, Mori S, Okuda K, Fukui T, Hatooka S, Shinoda M, Matsuo K, Yatabe Y, Yokoi K, Mitsudomi T
  • Journal Title: Ann Thorac Surg 86 Pages: 1084-1090
• [Journal Article] mRNA expression of RRM1 ERCC1 and ERCC2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines (2008)
  • Author(s): Shimizu J, Horio Y Osada H, Hida T, Hasegawa Y, Shimokata K, Takahashi T, Sekido Y, Yatabe Y
  • Journal Title: Respirology 13 Pages: 510-517
• [Journal Article] Epidermal growth factor receptor mutations in small cell lung cancer (2008)
  • Author(s): Tatematsu A, Shimizu J, Murakami Y. Horio Y, Nakamura S, Hida T, Mitsudomi T, Yatabe Y
  • Journal Title: Clin Cancer Res 14 Pages: 6092-6096
• [Journal Article] Intraoperative diagnosis of cancer metastasis in sentinel lymph node of oral cancer patients (2008)
  • Author(s): Terada A, Hasegawa Y, Yatabe Y, Hyodo I, Ogawa T, Hanai N, Ikeda A, Nagashima Y, Masui T, Hirakawa H, Nakashima T
  • Journal Title: Oral Oncol 44 Pages: 838-843
• [Journal Article] Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells : application for allogeneic transplantation (2008)
  • Author(s): Torikai H, Akatsuka Y, Yatabe Y, Morishima Y, Kodera Y Kuzushima K, Takahashi T
  • Journal Title: Int J Hematol 87 Pages: 467-473
  • NAID: 10021256331
• [Journal Article] Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma (2008)
  • Author(s): Toyooka S, Takano T, Kosaka T, Hotta K, Matsuo K, Ichihara S, Fujiwara Y, Soh J, Otani H, Kiura K, Aoe K, Yatabe Y, Ohe Y, Mitsudomi T, Date H
  • Journal Title: Cancer Sci 99 Pages: 303-308
  • NAID: 10024002340
• [Journal Article] Osteosarcoma with skeletal muscle metastasis (2008)
  • Author(s): Yamada K, Yatabe Y, Sugiura H
  • Journal Title: Arch Orthop Trauma Surg 128 Pages: 695-699
• [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer (2008)
  • Author(s): Yatabe Y, Takahashi T, Mitsudomi T
  • Journal Title: Cancer Res 68 Pages: 2106-2111
• [Journal Article] YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation (2008)
  • Author(s): Yokoyama T, Osada H, Murakami H, Tatematsu Y, Tamguchi T, Kondo Y, Yatabe Y, Hasegawa Y, Shimokata K, Horio Y, Hida T, Sekido Y
  • Journal Title: Carcinogenesis 29 Pages: 2139-2146
• [Journal Article] Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer (2008)
  • Author(s): Yatabe Y, et al.
  • Journal Title: Cancer Res 68 Pages: 2106-11
  • Peer Reviewed
• [Journal Article] Epidermal growth factor receptor mutations in small cell lung cancer (2008)
  • Author(s): Tatematsu A, et al.
  • Journal Title: Clin Cancer Res 14 Pages: 6092-6
  • Peer Reviewed
• [Journal Article] Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer (2008)
  • Author(s): Osada H, et al.
  • Journal Title: Cancer Res 68 Pages: 1647-55
  • Peer Reviewed
• [Journal Article] Decreased risk of colorectal cancer with the high Natural-Killer (NK)-cell activity NKG2D genotype in Japanese (2008)
  • Author(s): Furue H, et al.
  • Journal Title: Carcinogenesis 29 Pages: 316-20
  • Peer Reviewed
• [Journal Article] Identifying patients with peripheral-type early non-small cell lung cancer (T1N0M0) for whom irradiation of the primary focus alone could lead to successful treatment (2008)
  • Author(s): Fuwa N, et al.
  • Journal Title: The British journal of radiology 81 Pages: 815-820
  • Peer Reviewed
• [Journal Article] Interleukin-2 potentiation of cetuximab antitumor activity for epidermal growth factor receptor-overexpressing gastric cancer xenografts through antibody-dependent cellular cytotoxicity (2008)
  • Author(s): Hara M, et al.
  • Journal Title: Cancer Sci. 99 Pages: 1471-8
  • Peer Reviewed
• [Journal Article] Coincidence of mammary and sentinel lymph node papilloma (2008)
  • Author(s): Ichihara S, et al.
  • Journal Title: Am J Surg Pathol. 32 Pages: 784-792
  • Peer Reviewed
• [Journal Article] Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese (2008)
  • Author(s): Matsuo K, et al.
  • Journal Title: Cancer Sci. 99 Pages: 1202-8
  • Peer Reviewed
• [Journal Article] Sarcomatoid carcinoma of the thymus arising in metaplastic thymoma (2008)
  • Author(s): Moritani S, et al.
  • Journal Title: Histopathology 52 Pages: 409-411
  • Peer Reviewed
• [Journal Article] Clinical Features and Prognosis of Gastric MALT Lymphoma With Special Reference to Responsiveness to H. pylori Eradication and API2-MALT1 Status (2008)
  • Author(s): Nakamura T, et al
  • Journal Title: Am J Gastroenterol 103 Pages: 62-70
  • Peer Reviewed
• [Journal Article] Stepwise examination for differential diagnosis of primary lung cancer and breast cancer relapse presenting as a solitary pulmonary nodule in patients after mastectomy (2008)
  • Author(s): Okasaka T, et al.
  • Journal Title: Journal of surgical oncology 98 Pages: 510-514
  • Peer Reviewed
• [Journal Article] Subcategorization of lung cancer based on tumor size and degree of visceral pleural invasion (2008)
  • Author(s): Sakakura N, et al.
  • Journal Title: The Annals of thoracic surgery 86 Pages: 1084-1090
  • Peer Reviewed
• [Journal Article] mRNA expression of RRM1, ERCC1 and ERCC2 is not associated with chemosensitivity to cisplatin, carboplatin and gemcitabine in human lung cancer cell lines (2008)
  • Author(s): Shimizu J, et al.
  • Journal Title: Respirology 13 Pages: 510-517
  • Peer Reviewed
• [Journal Article] Intraoperative diagnosis of cancer metastasis in sentinel lymph node of oral cancer patients (2008)
  • Author(s): Terada A, et al.
  • Journal Title: Oral oncology 44 Pages: 838-843
  • Peer Reviewed
• [Journal Article] Aberrant expression of BCL2A1-restricted minor histocompatibility antigens in melanoma cells : application for allogeneic transplantation (2008)
  • Author(s): Torikai H, et al.
  • Journal Title: International journal of hematology 87 Pages: 467-473
  • Peer Reviewed
• [Journal Article] Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma (2008)
  • Author(s): Toyooka S, et al.
  • Journal Title: Cancer Sci. 99 Pages: 303-8
  • Peer Reviewed
• [Journal Article] Osteosarcoma with skeletal muscle metastasis (2008)
  • Author(s): Yamada K, et al.
  • Journal Title: Arch Orthop Trauma Surg 128 Pages: 695-699
  • Peer Reviewed
• [Journal Article] YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation (2008)
  • Author(s): Yokoyama T, et al.
  • Journal Title: Carcinogenesis 29 Pages: 2139-46
  • Peer Reviewed
• [Journal Article] Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(q21;q21) negative gastric mucosa-associated lymphoid tissue lymphomas (2007)
  • Author(s): Fukuhara N, Nakamura T, Nakagawa M, Tagawa H, Takeuchi I, Yatabe Y, Monshima Y. Nakamura S, Seto M
  • Journal Title: Genes Chromosomes Cancer 46 Pages: 784-790
• [Journal Article] Controversy about small peripheral lung adenocarcinomas : how should we manage them? (2007)
  • Author(s): Fukui T, Sakakura N, Mori S, Hatooka S. Shinoda M, Yatabe Y, Mitsudomi T
  • Journal Title: J Thorac Oncol 2 Pages: 546-552
• [Journal Article] Factors involved in lymph node metastasis in clinical stage I non-small cell lung cancer-From studies of 604 surgical cases (2007)
  • Author(s): Fuwa N, Mitsudomi T, Daimon T, Yatabe Y, Shinoda M, Hatooka S, Mori S, Fukui T, Inaba Y
  • Journal Title: Lung Cancer 57 Pages: 311-316
• [Journal Article] Distribution of Intraductal Lesions in Small Invasive Ductal Carcinoma of the Pancreas (2007)
  • Author(s): Hisa T, Suda K, Nobukawa B, Ohkubo H, Shiozawa S, Ishigame H, Yamao K, Yatabe Y
  • Journal Title: Pancreatology 7 Pages: 341-346
• [Journal Article] API2-MALT1 chimenc transcnpt-positive gastroduodenal MALT lymphoma with subsequent development of adenocarcinoma as a collision tumour over a clinical course of 7 years (2007)
  • Author(s): Isaka T, Nakamura T, Tajika M, Kawai H, Imaoka H, Okamoto Y. Aoki M, Inoue H, Takahashi K, Mizuno N, Sawaki A, Yamao K, Seto M, Yokoi T, Yatabe Y, Nakamura S
  • Journal Title: Histopathology 51 Pages: 119-123
• [Journal Article] Risk factors differ for non-small-cell lung cancers with and without EGFR mutation : assessment of smoking and sex by a case-control study in Japanese (2007)
  • Author(s): Matsuo K, Ito H, Yatabe Y, Hiraki A, Hirose K, Wakai K, Kosaka T, Suzuki T, Tajima K, Mitsudomi T
  • Journal Title: Cancer Sci 98 Pages: 96-101
• [Journal Article] Mutations of the epidermal growth factor receptor gene and related genes as determinanb of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer (2007)
  • Author(s): Mitsudomi T, Yatabe Y
  • Journal Title: Cancer Sci 98 Pages: 1817-1824
• [Journal Article] c-Maf expression in angioimmunoblastic T-cell lymphoma (2007)
  • Author(s): Murakami YI, Yatabe Y, Sakaguchi T, Sasaki E, Yamashita Y, Morito N, Yoh K, Fujioka Y, Matsuno F, Hata H, Mitsuya H, Imagawa S, Suzuki A, Esumi H, Sakai M, Takahashi S, Mori N
  • Journal Title: Am J Surg Pathol 31 Pages: 1695-1702
• [Journal Article] Clinical Features and Prognosis of Gastric MALT Lymphoma With Special Reference to Responsiveness to H. pylori Eradication and API2-MALTI Status (2007)
  • Author(s): Nakamura T, Seto M, Tajika M, Kawai H, Yokoi T, Yatabe Y, Nakamura S
  • Journal Title: Am J Gastroenterol
• [Journal Article] Malignant adenomyoepithelioma of the breast with matrix production may be compatible with one variant form of matrix-producing carcinoma : A case report (2007)
  • Author(s): Oka K, Sando N, Monya T, Yatabe Y
  • Journal Title: Pathol Res Pract 203 Pages: 599-604
• [Journal Article] LKBl gene mutations in Japanese lung cancer patients (2007)
  • Author(s): Onozato R, Kosaka T, Achiwa H, Kuwano H, Takahashi T, Yatabe Y, Mitsudomi T
  • Journal Title: Cancer Sci
• [Journal Article] Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas (2007)
  • Author(s): Sakamoto H, Shimizu J, Horio Y. Ueda R, Takahashi T, Mitsudomi T, Yatabe Y
  • Journal Title: J Pathol 212 Pages: 287-294
• [Journal Article] Breast-specific expression of MGB1/mammaglobin : an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers (2007)
  • Author(s): Sasaki E, Tsunoda N, Hatanaka Y Mori N, Iwata H, Yatabe Y
  • Journal Title: Mod Pathol 20 Pages: 208-214
• [Journal Article] Development-dependent expression of cyclin D3 in precursor T-cell lymphoblastic leukemia/lymphoma (2007)
  • Author(s): Sasaki E, Yatabe Y, Hashimoto M, Yamashita Y, Hasegawa Y, Kojima H, Nagasawa T, Mori N
  • Journal Title: Pathol Int 57 Pages: 53-59
  • NAID: 10020104959
• [Journal Article] igh-level expression of CD 109 is frequently detected in lung squamous cell carcinomas (2007)
  • Author(s): Sato T, Murakumo Y, Hagiwara S, Jijiiwa M, Suzuki C, Yatabe Y, Takahashi M
  • Journal Title: Pathol Int 57 Pages: 719-724
• [Journal Article] Predictive factors associated with prolonged survival in patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib (2007)
  • Author(s): Satouchi M, Negoro S, Funada Y, Urata Y, Shimada T, Yoshimura S, Kotam Y Sakuma T, Watanabe H, Adachi S, Takada Y Yatabe Y, Mitsudomi T
  • Journal Title: Br J Cancer 96 Pages: 1191-1196
• [Journal Article] Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study (2007)
  • Author(s): Suzuki T, Matsuo K, Hiraki A, Saito T, Sato S, Yatabe Y, Mitsudomi T, Hida T, Ueda R, Tajima K
  • Journal Title: Carcinogenesis 28 Pages: 1718-1725
• [Journal Article] A case of colonic morale with colitis cystica profunda, discussion 163 (2007)
  • Author(s): Tajika M, Nakamura T, Kawai H, Sawaki A, Mizuno N, Takahashi K, Yokoi T, Yatabe Y, Hirai T, Yamao K, Kato T
  • Journal Title: Gastrointest Endosc 65 Pages: 162-163
• [Journal Article] Pure acinic cell carcinoma of the breast in an 80-year-old Japanese woman (2007)
  • Author(s): Tanahashi C, Yabuki S, Akamine N, Yatabe Y, Ichihara S
  • Journal Title: Pathol Int 57 Pages: 43-46
  • NAID: 10020105418
• [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1 (2007)
  • Author(s): Tanaka H, Yanagisawa K, Shinjo K, Taguchi A, Maeno K, Tomida S, Shimada Y, Osada H, Kosaka T, Matsubara H, Mitsudomi T, Sekido Y, Tanimoto M, Yatabe Y, Takahashi T
  • Journal Title: Cancer Res 67 Pages: 6007-6011
• [Journal Article] Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32 (2007)
  • Author(s): Taniguchi T, Karnan S, Fukui T, Yokoyama T, Tagawa H, Yokoi K, Ueda Y, Mitsudomi T, Horio Y Hida T, Yatabe Y, Seto M, Sekido Y
  • Journal Title: Cancer Sci 98 Pages: 438-446
  • NAID: 10019482069
• [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach (2007)
  • Author(s): Tomida S, Yanagisawa K, Koshikawa K. Yatabe Y, Mitsudomi T, Osada H, Takahashi T
  • Journal Title: Oncogene 26 Pages: 4600-4608
• [Journal Article] The Impact of Sex and Smoking Status on the Mutational Spectrum of Epidermal Growth Factor Receptor Gene in Non small Cell Lung Cancer (2007)
  • Author(s): Toyooka S, Matsuo K, Shigematsu H, Kosaka T, Tokumo M, Yatabe Y, Ichihara S, Inukai M, Suehisa H, Soh J, Kiura K, Fong KM, Lee H, Wistuba, II, Gazdar AF, Mitsudomi T, Date H
  • Journal Title: Clin Cancer Res 13 Pages: 5763-5768
• [Journal Article] Neuroendocrine tumor metastasis to the thyroid gland (2007)
  • Author(s): Yamada H, Hasegawa Y, Mitsudomi T, Nakashima T, Yatabe Y
  • Journal Title: Int J Clin Oncol 12 Pages: 63-67
  • NAID: 10018565838
• [Journal Article] Osteosarcoma with skeletal muscle metastasis (2007)
  • Author(s): Yamada K, Yatabe Y, Sugiura H
  • Journal Title: Arch Orthop Trauma Surg
• [Journal Article] A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer (2007)
  • Author(s): Yanagisawa K, Tomida S, Shimada Y, Yatabe, Mitsudomi T, Takahashi T
  • Journal Title: J Natl Cancer Inst 99 Pages: 858-867
• [Journal Article] Epidermal growth factor receptor mutations in lung cancers (2007)
  • Author(s): Yatabe Y, Mitsudomi T
  • Journal Title: Pathol Int 57 Pages: 233-244
  • NAID: 10020104116
• [Journal Article] Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer (2007)
  • Author(s): Yoshida K, Yatabe Y, Park JY, Shimizu J, Horio Y, Matsuo K, Kosaka T, Mitsudomi T. Hida T
  • Journal Title: J Thorac Oncol 2 Pages: 22-28
• [Journal Article] Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas (2007)
  • Author(s): Sakamoto H, . Yatave, Y.
  • Journal Title: The Journal of pathology 212 Pages: 287-294
  • Peer Reviewed
• [Journal Article] Epidermal growth factor receptor mutations in lung cancers. (2007)
  • Author(s): Yatabe Y, Mitsudomi T
  • Journal Title: Pathology international. 57 Pages: 233-244
  • NAID: 10020104116
  • Peer Reviewed
• [Journal Article] Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer (2007)
  • Author(s): Yoshida K, Yatabe Y, et. al.
  • Journal Title: Journal of Thoracic Oncology 2 Pages: 22-28
  • Peer Reviewed
• [Presentation] シンポジウム6肺腺癌の特性:EGFR・KRAS遺伝子変異の異同 (2008)
  • Author(s): 谷田部恭
  • Organizer: 第49回日本肺癌学会
  • Place of Presentation: 第49回日本肺癌学会
  • Year and Date: 2008-11-14
• [Presentation] EGFR遺伝子変異IKRAS遺伝子変異の差 (2008)
  • Organizer: 日本肺癌学会シンポジウム「肺腺癌の特性」
  • Place of Presentation: 小倉
  • Year and Date: 2008-11-12
• [Presentation] Differential diagnosis of Lung cancer (2008)
  • Organizer: Nanjing International Symposium on Cancer Treatment
  • Place of Presentation: China
  • Year and Date: 2008-10-16
• [Presentation] Differential Diagnosis of Ovarian Cancer From Primary Lung Cancer (2008)
  • Author(s): Yasushi Yatabe
  • Organizer: Nanjing international symposium on cancer treatment
  • Place of Presentation: Nanjing international symposium on cancer treatment
  • Year and Date: 2008-10-16
• [Presentation] 肺癌の多発と転移の評価 (2008)
  • Organizer: 日本外科病理学会ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2008-09-27
• [Presentation] Emerging molecular landscape for lung adenocarcinoma development (2008)
  • Organizer: Kazusa Akademia Respiratory Forum
  • Place of Presentation: Chiba
  • Year and Date: 2008-09-20
• [Presentation] 肺腫瘍の病理 (2008)
  • Organizer: 日本病理学会中部・近畿支部合同夏期病理診断セミナー
  • Year and Date: 2008-08-26
• [Presentation] 肺腺癌とterminal respiratory unit (2008)
  • Organizer: 日本肺癌学会ワークショップ
  • Place of Presentation: つくば市
  • Year and Date: 2008-07-19
• [Presentation] 肺腺癌とterminal respiratory unit (2008)
  • Organizer: 日本病理学会総会ワークショップ
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-15
• [Presentation] Overview of Molecular Classification of Breast Cancer (2008)
  • Organizer: ACCIS XIII Advances in Breast Cancer Research
  • Place of Presentation: Nagoya
  • Year and Date: 2008-02-16
• [Presentation] Proposed distinction between terminal respiratory unit and proximal subtypes (2008)
  • Organizer: IASLC pathology panel meeting at Memorial Sloan Kettenng Cancer Center
  • Place of Presentation: New York
• [Presentation] 呼吸器疾患研究における新たなエンティティとテクノロジー:末梢呼吸ユニットと肺腺癌 (2008)
  • Author(s): 谷田部恭
  • Organizer: 第97回 日本病理学会ワークショップ
  • Place of Presentation: Aichi Cancer Center, Nagoya, Japan
• [Presentation] Lung adenocarcinoma-proposed distinction (2008)
  • Author(s): Yatabe Y.
  • Organizer: INTERNATIONAL MULTIDISCIPLINARY LUNG ADE NOCARCINOMA CLASSIFICATION
  • Place of Presentation: New York, NY, U.S.A.
• [Presentation] 肺がんの病理解析とバイオマーカ開発 (2007)
  • Organizer: 産業総合研究所セミナー
  • Year and Date: 2007-11-30
• [Presentation] 免疫組織学的解析や遺伝子診断を用いた転移性腫瘍の鑑別診断 (2007)
  • Organizer: 筑波大学病院セミナー
  • Place of Presentation: つくば市
  • Year and Date: 2007-11-30
• [Presentation] 病理組織像と悪性度 (2007)
  • Organizer: 日本癌治療学会教育セミナー
  • Place of Presentation: 京都
  • Year and Date: 2007-10-26
• [Presentation] 体腔液の細胞診 (2007)
  • Organizer: 日本臨床細胞診学会東海連合会例会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2007-09-27
• [Presentation] Poster Discussant (PD1-3, Pathology Session) (2007)
  • Organizer: World Conference of Lung Cancer
  • Place of Presentation: Seoul Korea
  • Year and Date: 2007-09-03
• [Book] 新細胞診診断学入門(第2版)、I 総論, 分子生物学
  • Publisher: 名古屋大学出版会
• [Book] ロビンス&コートラン 病理学アトラス
  • Publisher: Elsevier Japan
• [Patent(Industrial Property Rights)] 肺腺癌患者の術後予後を予測するための方法及び組成物 (2007)
  • Inventor(s): 高橋隆, 冨田秀太, 竹内俊幸, 谷田部恭, 光冨徹哉
  • Filing Date: 2007-12-28