Identification of tumor specific antigens of mesothelioma for it's diagnosis and therapy
| Project/Area Number |
19590392
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Okayama University |
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Principal Investigator |
UENAKA Akiko Okayama University, 大学院・医歯薬学総合研究科, 講師 (50273967)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 腫瘍 / 細胞 / がん抗原 / 宿主免疫応答 / 悪性中皮腫 / SEREX / 抗体 / 診断マーカー / 中皮種細胞株樹立 / 抗原解析 / サイトカイン産生 / XAGE-1 |
|---|
| Research Abstract |
本研究では、悪性胸膜中皮腫(MPM)の早期診断のためのマーカーの同定と治療法の開発を目的として、中皮腫特異性がより明確な抗原の検索同定を目標とした。悪性中皮腫患者胸水から樹立した細胞株から cDNA ライブラリーを作成し、胸水中のIgG抗体が認識する抗原遺伝子のスクリーニングを行い, 2つの抗原をクローニングした。抗原遺伝子から組み換えタンパクを作成しELISA法による検査法の確立と免疫組織染色等に使用するモノクローナル抗体作成実験を継続進行中である。
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Report
(3 results)
Research Products
(78 results)
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[Journal Article] Old LJ and Nakayama E. Identification of the HERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity2008
Author(s)
Ishida T, Obata Y, Ohara N, Matsushita H, Sato S, Uenaka A, Saika T, Miyamura T, Chayama K, akamura Y, Wada H, Yamashita T, Morishima T
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Journal Title
Cancer Immunity 8
Pages: 15-15
Related Report
Peer Reviewed
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[Journal Article] Analysis of peripheral and local anti-tumor immune response in esophageal cancer patients after NY-ESO-1 protein vaccination2008
Author(s)
Wada H, Sato E, Uenaka A, Isobe M, Kawabata R, Nakamura Y, Iwase S, Yonezawa K, Yamasaki M, Miyata H, Doki Y, Shiku H, Jungbluth AA, Ritter G, Murphy R, Hoffman EW, Old LJ, Monden M and Nakayama E
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Journal Title
Int. J. Cancer 123(10)
Pages: 2362-2369
Related Report
Peer Reviewed
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[Journal Article] Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient2008
Author(s)
Tsuji K, Hamada T, Uenaka A, Wada H, Sato E, Isobe M, Asagoe K, Yamasaki O, Shiku H, Ritter G, Murphy R, Hoffman E, Old LJ, Nakayama E and Iwatsuki K
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Journal Title
Cancer Immunol. Immunother 57(10)
Pages: 1429-1437
Related Report
Peer Reviewed
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[Journal Article] T-cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein2007
Author(s)
Uenaka A, Wada H, Isobe M, Saika T, Tsuji K, Sato E, Sato S, Noguchi Y, Kawabata R, Yasuda T, Doki Y, Kumon H, Iwatsuki K, Shiku H, Monden M, Jungbluth AA, Ritter G, Murphy R, Hoffman E, Old LJ and Nakayama E
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Journal Title
Cancer Immunity 7
Pages: 9-20
Related Report
Peer Reviewed
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[Journal Article] Antibody response against NY-ESO-1 in CHP-NY-ESO-1 vaccinated patients2007
Author(s)
Kawabata R, Wada H, Idobe M, Saika T, Sato S, Uenaka A, Doki Y, Yasuda T, Kumon H, Tsuji K, Iwatsuki K, Ritter G, Murphy R, Hoffman E, Old LJ, Monden M and Nakayama E
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Journal Title
Int. J. Cancer 120
Pages: 2178-2184
Related Report
Peer Reviewed
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[Book] 抗体実験マニュアル2008
Author(s)
上中明子, 中山睿一、羊土社
Total Pages
256
Publisher
高津聖志、三宅健介, 山元弘、瀧伸介編
Related Report
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