Carcinogenic risk assessment of nano-sized particles
| Project/Area Number |
19590393
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kagawa University |
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Principal Investigator |
IMAIDA Katsumi Kagawa University, 医学部, 教授 (90160043)
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| Co-Investigator(Kenkyū-buntansha) |
KUNO Toshiya 岐阜大学, 大学院・医学系研究科, 腫瘍病理 (00345779)
YOKOHIRA Masanao 香川大学, 医学部, 助教 (70403780)
HASHIMOTO Nozomi 香川大学, 医学部, 助教 (60448371)
INOUE Tatsushi 香川大学, 医学部, 助教 (80384593)
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| Project Period (FY) |
2007 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ナノサイズ粒子 / ラット肝中期発癌試験 / 気管内投与 / 強制胃内投与 / 経静脈投与 / GST-P positive foci / 酸化銅 / 二酸化チタン / ナノサイズ微粒子 / 発がんリスク / 腫瘍 / 肝発がん / 中期発がん性試験法 / ラット / 経気管内投与 |
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| Research Abstract |
Carcinogenesis of nanoparticles remains uncertain despite nano-sized materials are widely used. In this study, liver carcinogenesis of nano- and micro-sized particles (Copper oxide;CuO, Titanium dioxide ; TiO_2) was examined after exposure of three different routes. Consequently, these results indicate that nanoparticles have promoting potential on the liver carcinogenesis.
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Report
(6 results)
Research Products
(54 results)
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[Journal Article] Tumorigenesis of 2-Amino-3,8-dimethylimidazo[4,5-f]qu inoxaline (MeIQx), but not enhancing effects of concomitant high fat diet, on lung carcinogenesis in female A/J mice.2010
Author(s)
Takeuchi H, Saoo K, Yamakawa K, Matsuda Y, Yokohira M, Zeng Y, Kuno T, Totsuka Y, Takahashi M, Wakabayashi K, Imaida K.
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Journal Title
Oncol.Lett. 1
Pages: 137-142
Related Report
Peer Reviewed
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[Journal Article] Different threshold levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) initiation of lung and colon carcinogenesis and the effects of an additional initiation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice.2010
Author(s)
Suzuki S, Yokohira M, Hashimoto N, Saoo K, Matsuda Y, Yamakawa K, Nakano Y, Kuno T, Imaida K.
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Journal Title
Molecular Medicine Reports 3
Pages: 301-307
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemically detected expression of p27kip1 and skp2 predicts survival in patients with intrahepatic cholangiocarcinomas.2009
Author(s)
Hashimoto N, Yachida S, Okano K, Wakabayashi H, Imaida K, Kurokohchi K, Masaki T, Kinoshita H, Tominaga M, Ajiki T, Ku Y, Okabayashi T, Hanazaki K, Hiroi M, Izumi S, Mano S, Okada S, Karasawa V, Maeba V, Suzuki Y.
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Journal Title
Ann.Surg.Oncol. 16
Pages: 395-403
Related Report
Peer Reviewed
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[Journal Article] Enhancing effects of a high fat diet on 2-amino-3,8-dimethylimidazo[4,5-f]qui noxaline (MeIQx) induced lung tumorigenesis in female A/J mice.2009
Author(s)
Matsuda Y, Takeuchi H, Yokohira M, Saoo K, Hosokawa K, Yamakawa K, Zeng Y, Totsuka Y, Wakabayashi K, Imaida K.
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Journal Title
Molecular Medicine Reports 2
Pages: 701-706
Related Report
Peer Reviewed
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[Journal Article] CYP2A6 overexpression in human lung cancers corelates with a high malignant status2007
Author(s)
Matsuda Y, Yamakawa K, Saoo K, Hosokawa K, Yokohira M, Kuno T, Iwai J, Shirai T, Obika K, Kamataki T, Imaida K
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Journal Title
Oncol Rep. 18
Pages: 53-57
Related Report
Peer Reviewed
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