Identification of cytogenesis of pancreatic cancer in Ras transgenic rats
| Project/Area Number |
19590401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
FUKAMACHI Katsumi Nagoya City University, 大学院・医学研究科, 助教 (90381798)
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| Co-Investigator(Kenkyū-buntansha) |
TSUDA Hiroyuki 名古屋市立大学, 大学院・医学研究科, 特任教授 (30094387)
ALEXANDER David 名古屋市立大学, 大学院・医学研究科, 研究員 (00335267)
津田 洋幸 名古屋市立大学, 大学院・医学研究科, 教授 (10163809)
ALEXANDER David 名古屋市立大学, 大学院・医学研究科, 客員教授 (90381805)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腫瘍 / 膵管がん / Ras / トランスジェニックラット / ras / 膵がん |
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| Research Abstract |
Pancreatic ductal adenocarcinoma (PDA) is one of the most debilitating malignancies in humans. A thorough understanding of the cytogenesis of this disease will aid in establishing successful treatments. We have developed an animal model which uses adult ras^<G12V> transgenic rats in which oncogene expression is regulated by the Cre/loxP system. We showed that the origin of PDA is duct, intercalated duct, and centroacinar cells, but not acinar cells.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.2010
Author(s)
Tanaka, H., Fukamachi, K., Futakuchi, M., Alexander, D.B., Long, N., Tamamushi, S., Minami, K., Seino, S., Ohara, H., Joh, T., Tsuda, H.
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Journal Title
Cancer Sci 101
Pages: 341-346
NAID
Related Report
Peer Reviewed
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[Journal Article] An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas.2009
Author(s)
Fukamachi, K., Tanaka, H., Hagiwara, Y., Ohara, H., Joh, T., Iigo, M., Alexander, D.B., Xu, J., Long, N., Takigahira, M., Yanagihara, K., Hino, O., Saito, I., Tsuda, H.
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Journal Title
Biochem Biophys Res Commun 390
Pages: 636-641
Related Report
Peer Reviewed
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[Journal Article] Purple corn color suppresses Ras protein level and inhibits 7, 12-dimethylbenz[a]anthracene-indu ced mammary carcinogenesis in the rat.2008
Author(s)
Fukamachi, K., Imada, T., Ohshima, Y., Xu, J., Tsuda, H.
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Journal Title
Cancer Sci 99
Pages: 1841-1846
Related Report
Peer Reviewed
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[Journal Article] Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats.2007
Author(s)
Tsuda, H., Iigo, M., Takasuka, N., Ueda, S., Ohshima, Y., Fukamachi, K., Shirai, T., Hirano, S., Matsuda, E., Wakabayashi, K.
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Journal Title
Food Chem Toxicol 45
Pages: 1013-1019
Related Report
Peer Reviewed
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[Journal Article] Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens.2007
Author(s)
Ohnishi, T., Fukamachi, K., Ohshima, Y., Jiegou, X., Ueda, S., Iigo, M., Takasuka, N., Naito, A., Fujita, K., Matsuoka, Y., Izumi, K., Tsuda, H.
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Journal Title
Toxicol Pathol 35
Pages: 436-443
Related Report
Peer Reviewed
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