Investigation of the significance of HERV expression in cancer cells for development of effective cancer therapy

• Project/Area Number: 19590405
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Keio University
• Principal Investigator: KUDOH Chie Keio University, 医学部, 助教 (90424126)
• Co-Investigator(Kenkyū-buntansha): KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: がん / 内因性レトロウイルス / CTLエピトープ / 転移 / 免疫抑制 / ペプチド / 癌 / 腫瘍特異的抗原

Research Abstract

様々な癌細胞に高発現している内因性レトロウイルス(HERV)抗原に関する免疫学的・分子生物学的な解析を行った結果、1) HERV抗原特異的に抗腫瘍活性を示すCTLを誘導できるペプチド配列(CTLエピトープ)を同定し、さらに、2) 癌細胞におけるHERVの発現が、癌治療上問題視されている悪性因子「癌転移」と「免疫抑制」の両者に深く関与していることを解明した。「ワクチン効果」と「悪性要因除去」という二つの異なるアプローチで宿主免疫を効果的に増強できる可能性を提示し、新たな癌治療法として提案するに至った。

Research Products

• [Journal Article] Cancer metastasis is accelerated through immunosuppression during snail-induced EMT of cancer cells (2009)
  • Author(s): Chie Kudo-Saito, Hiromi Shirako, Tadashi Takeuchi and Yutaka Kawakami
  • Journal Title: Cancer Cell 15 Pages: 195-206
  • Peer Reviewed
• [Journal Article] Cancer metastasis is accelerated through immunosuppression during snail-induced EMT of cancer cells (2009)
  • Author(s): Kudo-Saito c., et al.
  • Journal Title: Cancer Cell 15 Pages: 195-206
  • Peer Reviewed
• [Presentation] DC impairment by IL-13 from humancolon cancer cells during EMT (2008)
  • Author(s): 工藤千恵
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] DC impairment by IL-13 from human colon cancer cells during EMT (2008)
  • Author(s): 工藤 千恵
  • Organizer: 第38回日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Enhancement of immunoescape of cancer cells by HERV expression (2008)
  • Author(s): 工藤千恵
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Simultaneous inhibition of tumor metastasis and immunosuppression induced by tumor cells during EMT utilizing MCP-1 blockade (2008)
  • Author(s): 工藤千恵
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Enhancement of immunoescape of cancer cells by HERV expression (2008)
  • Author(s): 工藤 千恵
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Simultaneous inhibition of tumor metastasis and immunosuppression induced by tumor cells during EMT utilizing MCP-1 blockade (2008)
  • Author(s): 工藤 千恵
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Cancer metastasis is accelerated through immunosuppression during snail-induced EMT of cancer cells (2008)
  • Author(s): 工藤千恵
  • Organizer: 日本がん免疫学会(旧SFCI)
  • Place of Presentation: 大宮
  • Year and Date: 2008-07-02
• [Presentation] Immunosuppressive mechanisms induced by tumor cells during EMT leading to tumor metastasis (2008)
  • Author(s): 工藤千恵
  • Organizer: 米国癌学会議
  • Place of Presentation: 米国・サンディエゴ
  • Year and Date: 2008-04-14
• [Presentation] Immunosuppressive mechanisms induced by tumor cells during EMT leading to tumor metastasis (2008)
  • Author(s): 工藤 千恵
  • Organizer: AACR 99th Annual Meeting 2008
  • Place of Presentation: 米国(サンディエゴ)
  • Year and Date: 2008-04-14
• [Presentation] Possible mechanism of metastasis enhancement during EMT by mediating via immunosuppression involving Treg cell (2007)
  • Author(s): 工藤千恵
  • Organizer: 日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Induction of Foxp3+ regulatory T cells by colon cancer cells during EMT (2007)
  • Author(s): 工藤千恵
  • Organizer: 日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Immunosuppressive mechanism induced by tumor cells during EMT (2007)
  • Author(s): 工藤千恵
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Patent(Industrial Property Rights)] 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 (2008)
  • Inventor(s): 工藤千恵
  • Industrial Property Rights Holder: 慶應義塾
  • Filing Date: 2008-08-22
• [Patent(Industrial Property Rights)] がんの診断方法と治療方法 (2008)
  • Inventor(s): 工藤千恵
  • Industrial Property Rights Holder: 慶應義塾
  • Industrial Property Number: 2008-239943
  • Filing Date: 2008-09-18
  • Overseas
• [Patent(Industrial Property Rights)] 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 (2008)
  • Inventor(s): 工藤 千恵
  • Industrial Property Rights Holder: 慶應義塾
  • Filing Date: 2008-08-22
• [Patent(Industrial Property Rights)] 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 (2008)
  • Inventor(s): 工藤 千恵
  • Industrial Property Rights Holder: 慶應義塾
  • Filing Date: 2008-08-22
  • Overseas
• [Patent(Industrial Property Rights)] がんの診断方法と治療方法 (2008)
  • Inventor(s): 工藤 恵
  • Industrial Property Rights Holder: 慶應義塾
  • Industrial Property Number: 2008-239943
  • Acquisition Date: 2008-09-18