| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
In the present study, we analyze the effect of microRNAs, recently discovered small non-coding RNAs, on the development and pathogenesis of cancer using their transgenic mice. We show that the tumor development of the small intestines of APC^<min> mice, which are model mice of familial adenomatous polyposis, is inhibited when crossed to miR-143 transgenic mice. We also demonstrate that proto-oncogene c-myc is downregulated in transgenic tumors.
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