Basic studies on the treatment and prevention of hepatocellular carcinoma with interferon
| Project/Area Number |
19590412
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kurume University |
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Principal Investigator |
YANO Hirohisa Kurume University, 医学部, 教授 (40220206)
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| Co-Investigator(Kenkyū-buntansha) |
OGASAWARA Sachiko 久留米大学, 医学部, 講師 (40258405)
AKIBA Jun 久留米大学, 医学部, 講師 (00341305)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 腫瘍 / サイトカイン / インターフェロン / アポトーシス / 阻害剤 / 分子標的薬剤 / 肝細胞癌 / 血管内皮細胞増殖因子 / ベバシズマブ / ヌードマウス / チロシンキナーゼ阻害剤 / NFκB阻害剤 / 細胞周期 / 細胞株 / p21 / Cox-2阻害剤 / TRAIL / TRAIL receptor |
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| Research Abstract |
To induce efficient anti-proliferative effect of interferon (IFN) on hepatocellular carcinoma cells, we performed the following investigation : 1) combination of other drugs with IFN, 2) application of new drug delivery system, and 3) determination and functional analysis of the molecules closely related with IFN-mediated apoptosis induction. As a result, combination of IFN with anti-angiogenesis drug was effective to a certain extent. New drug delivery system worked to some extent and may be more effective after some improvement. XAF-1 and TRAIL were closely related with the induction of apoptosis and the regulation of XAF-1 and TRAIL will modify the anti-proliferative effect of IFN.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Growth inhibitory effects of pegylated IFN-a2b and 5-fluorouracil in combination on renal cell carcinoma cell lines in vitro and in vivo.2008
Author(s)
Moriya F., Ogasawara S., Basaki Y., Akiba J., Kojiro S., Fukahori S., Ishizaki H., Nishida N., Matsuoka K., Kojiro M., Kuwano M., Yano H.
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Journal Title
Int J Oncol 33
Pages: 647-655
Related Report
Peer Reviewed
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[Journal Article] Alteration of dihydropyrimidine dehydrogenase expression by IFN-βaffects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells Mol Cancer Ther2007
Author(s)
Oie S, Ono M, Fukushima H, Hosoi F, Yano H, Maruyama Y, Kojiro M, Terada T, Hirano K, Kuwano M, Yamada Y.
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Journal Title
Related Report
Peer Reviewed
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