Investigation of role of histone modifier protein in carcinogenesis and carcinoma cell progression

• Project/Area Number: 19590417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• Principal Investigator: FUJII Satoshi National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所及び東病院臨床開発センター (30314743)
• Co-Investigator(Kenkyū-buntansha): OCHIAI Atsushi 国立がんセンター, 研究所及び東病院臨床開発センター・・臨床腫瘍病理部, 部長
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: ヒストン / メチル化 / ヒストン修飾 / がん

Research Abstract

多種多様ながんにおいて高発現しているヒストン修飾を制御する分子が、腫瘍抑制遺伝子などの細胞の恒常性を維持することのできる重要な遺伝子群の発現の抑制をもたらし、細胞の表現型を変化させることによって、がんの発生と進展を引き起こしていることを明らかにした。

Research Products

• [Journal Article] Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells (2008)
  • Author(s): Fujii S and Ochiai A
  • Journal Title: Cancer Sci. 99 Pages: 738-746
  • NAID: 10024004916
  • Peer Reviewed
• [Journal Article] Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation. (2008)
  • Author(s): Fujii S, Ito K, Ito Y, Ohciai A.
  • Journal Title: J. Biol Chem. 283 Pages: 17324-32
  • Peer Reviewed
• [Journal Article] Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation (2008)
  • Author(s): Fujii S, Ito K, Ito Y, Ochiai A.
  • Journal Title: J Biol Chem. 283 Pages: 17324-32
  • Peer Reviewed
• [Journal Article] Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells (2008)
  • Author(s): Fujii S, and Ochiai A.
  • Journal Title: Cancer Sci. 99 Pages: 738-746
  • NAID: 10024004916
  • Peer Reviewed
• [Presentation] EZH2 down-regulates E-cadherin and RUNX3 by increasing histone H3 methylation (2008)
  • Author(s): 藤井誠志, 落合淳志
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-28
• [Presentation] EZH2 down-regulates E-cadherin and RUNX3 by increasing histone H3 methylation. (2008)
  • Author(s): 藤井誠志、落合淳志
  • Organizer: 第67回日本癌学会学術総会
• [Presentation] Enhancer of zeste homologue 2(EZH2)down-regulates Runx3 by mediating histone H3 methylation (2007)
  • Author(s): 藤井 誠志、落合 淳志
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-10-04
• [Presentation] Enhancer of zeste homologue 2 (EZH2) down-regulates Runx3 by mediating histone H3 methylation (2007)
  • Author(s): 藤井誠志、落合淳志
  • Organizer: 第66回日本癌学会学術総会
• [Presentation] 胃癌におけるEZH2発現の意義
  • Author(s): 藤井誠志、落合淳志
  • Organizer: 第80回日本胃癌学会総会