Suppression mechanism for anti-tumor immune response through sialyl In antigen
| Project/Area Number |
19590420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
IKEHARA Yuzuru National Institute of Advanced Industrial Science and Technology, 糖鎖医工学研究センター, 研究チーム長 (10311440)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMURA Kunio 浜松医科大学, 感染症学講座, 准教授 (10227407)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | シアル酸 / がん / 腹腔内転移 / 腫瘍免疫 / シアリルTn / ELISPOTアッセイ / TH1 / 2細胞 / がん関連糖鎖 / 病理学 / 糖鎖 / 癌 |
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| Research Abstract |
STn 抗原を発現するヒト胃がんは、腹腔内に播種性に進展しやすく、有為に予後不良となる事が知られている。本研究では、STn 抗原を産生する様に改変した細胞を用い、OVA をモデルがん抗原として検討した。STn 抗原を産生する様に改変した細胞を接種したマウスのリンパ組織では、不活性型ST6GalNAc I 遺伝子を導入したSTn 抗原発現の無い細胞を接種したマウスに比べて、免疫抑制をする細胞がより多く誘導され、OVA 抗原に特異的な細胞障害性T 細胞数も抑制される事を見いだした。また、シアル酸被覆リポソームにOVA を封入して投与するモデル実験でも、同様の結果を得る事ができた。これらの事は、STn 抗原等シアル酸を有為に高発現する細胞は、腫瘍免疫による排除を効率良く回避できるメカニズムの存在を示唆する。
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Report
(3 results)
Research Products
(43 results)
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[Journal Article] Strategy for Glycoproteomics: Identification of Glyco-Alteration Using Multiple Glycan Profiling Tool2009
Author(s)
Ito H, Kuno A, Sawaki H, Sogabe M, Ozaki H, Tanaka Y, Mizokami M, Shoda JI, Angata T, Sato T, Hirabayashi J, Ikehara Y, Narimatsu H.
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Journal Title
J Proteome Res [Epub ahead of print]
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[Journal Article] Mice lacking a1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors2007
Author(s)
Kudo T., Fujii T., Ikegami S., Inokuchi K., Takayama Y., Ikehara Y., Nishihara S., Togayachi A,. Takahashi S., Tachibana K., Yuasa S, Narimatsu H
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Journal Title
Glycobiology 17(1)
Pages: 1-9
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[Journal Article] Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation2007
Author(s)
Togayachi A., Kozono Y, Ishida H., Abe S., Suzuki N., Tsunoda Y., Hagiwara K., Kuno A., Ohkura T., Sato N., Sato T., Hirabayashi J., Ikehara Y., Tachibana K., and Narimatsu H
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Journal Title
Proc Natl Acad Sci U S A. 104(40)
Pages: 15829-34
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[Journal Article] Glycophorin A knockout mice, which lost sialoglycoproteins from the red blood cell membrane, are resistant to lethal infection of Babesia rodhaini2007
Author(s)
Takabatake N., Okamura M., Yokoyama N., Ikehara Y., Akimitsu N., Arimitsu N, Hamamoto H., Sekimizu K., Suzuki H., and Igarashi I
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Journal Title
Veterinary Parasitology 148(2)
Pages: 93-101
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[Journal Article] Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation2007
Author(s)
Togayachi A., Kozono Y, Ishida H., Abe S., Suzuki N., Tsunoda Y., Hagiwara K., Kuno A., Ohkura T., Sato N., Sato T., Hirabayashi J., Ikehara Y., et. al.
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Journal Title
Proc Natl Acad Sci USA 104
Pages: 15829-15834
Related Report
Peer Reviewed
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[Journal Article] Glycophorin A knockout mice, which lost sialoglycoproteins from the red blood cell membrane, are resistant to lethal infection of Babesia rodhaini2007
Author(s)
Takabatake N., Okamura M., Yokoyama N., Ikehara Y., Akimitsu N., Arimitsu N, Hamamoto H., Sekimizu K., Suzuki H., and Igarashi I.
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Journal Title
Veterinary Parasitology 148
Pages: 93-101
Related Report
Peer Reviewed
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