New development in study of mitochondrial translation system of theparasitic nematode
| Project/Area Number |
19590425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YOSHINARI Shigeo The University of Tokyo, 大学院・医学系研究科, 助教 (70253317)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yoh-ichi 東京大学, 大学院・医学系研究科, 准教授 (90323568)
OHTSUKI Takashi 岡山大学, 大学院・自然科学研究科, 準教授 (80321735)
YOKOBORI Shin-ichi 東京薬科大学, 生命科学部, 講師 (40291702)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 寄生虫 / ミトコンドリア / タンパク質合成系 / tRNA / EF-Tu / 線形動物 / 節足動物 / 寄生性線虫 / リボソーム / EF-G |
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| Research Abstract |
動物ミトコンドリア(mt)のタンパク質合成系は、より短い機能性RNAを用いる。我々は、短縮化したmt tRNA を持つ種と持たない種が混在する節足動物で、短縮化したtRNAを持たない昆虫の2つのEF-Tu のうちの1つが、短縮化したtRNA と結合できることを示した。また、植物寄生性線虫ミトコンドリアで遺伝子が未同定だったtRNA のうち1種の発現を同定した。このtRNA は発現が確認された中で最も短い。
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Report
(3 results)
Research Products
(56 results)
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[Journal Article] Functionalimportance of Crenarchaea-specificextra-loop revealed by an X-raystructure of a hetero-tetramericcrenarchaeal splicing endonuclease.2009
Author(s)
Yoshinari, S., Shiba, T., Inaoka, D.,Itoh, T., Kurisu, G., Harada, S., Kita,K., Watanabe, Y.
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Journal Title
Nucleic Acids Res., accepted
Related Report
Peer Reviewed
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[Journal Article] Modified uridines withC5-methylene substituents at the firstposition of the tRNA anticodonstabilize U.G wobble pairing duringdecoding2008
Author(s)
Kurata, S., Weixlbaumer, A., Ohtsuki,T., Wada, T., Kirino, Y., Takai, K.,Watanabe, K. Ramakrishnan, V. and Suzuki, T.
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Journal Title
J.Biol.Chem. 283
Pages: 18801-18811
Related Report
Peer Reviewed
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[Journal Article] Isolation of small RNAs usingbiotinylated PNAs2008
Author(s)
Ohtsuki, T., Fujimoto, T., Kamimukai,M., Kumano, C., Kitamatsu, M., Sisido,M.
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Journal Title
Journal of Biochemistry 114
Pages: 415-418
Related Report
Peer Reviewed
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[Journal Article] Modified uridines with C5-methylene substituentS ,at the first position of the tRNA anticodon stabilize U,QwObleg during decoding2008
Author(s)
Kurata, S. , Weixlbaumer, A. , Ohtsuki, T., Wada, T., Ki rino, Y. , Takai, K. , Watana be, K. Ramakrishnan, V. and Suzuki, T.
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Journal Title
J. Biol. Chem. 283
Pages: 18801-18811
Related Report
Peer Reviewed
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[Journal Article] Isolation of small RNAs using biotinylated PNAs.2008
Author(s)
htsuki, T., Fujimoto, T., Kamimukai, M., Kumano, C., Kitamatsu, M. , Sisido, M.
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Journal Title
Journal of Biochemistry 114
Pages: 415-418
Related Report
Peer Reviewed
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[Journal Article] Mitochondria and apicoplastof Plasmodium falciparum : behaviour onsubcellular fractionation and theimplication2007
Author(s)
Kobayashi T, Sato S, Takamiya S,Komaki-Yasuda K, Yano K, Hirata A,Onitsuka I, Hata M, Mi-ichi F, Tanaka T,Hase T, Miyajima A, Kawazu S, WatanabeY, Kita K.
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Journal Title
Mitochondrion 7
Pages: 125-132
Related Report
Peer Reviewed
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