Role of macrophage mannose receptor in malaria

• Project/Area Number: 19590426
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: KAMEI Kaeko Kyoto Institute of Technology, 工芸科学研究科, 准教授 (00214544)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 感染症 / 寄生虫 / マラリア / マクロファージマンノースレセプター / 脳マラリア / サイトカイン

Research Abstract

マクロファージマンノースレセプター(MR)は、マウスにおいてマラリアの重症化に関与している。その重症化機構をサイトカインの産生量に着目して検討した結果、MRは炎症性サイトカインの発現を誘導することを明らかにした。よって、MRによるマラリアの重症化機構は過剰な炎症反応の惹起であると考えられた。さらに、ブタMRを用いて、MRと感染赤血球成分がマンノースを介して結合することを明らかにした。

Research Products

• [Journal Article] Effects of amino acids on malarial heme crystallization (2008)
  • Author(s): D.T. Uyen, N.T. Huy, D.T.X. Trang, N.T. Nhien, T. Oida, K. Hirayama, S. Harada, and K. Kamei
  • Journal Title: Biol Pharm Bull 31(8) Pages: 1483-1488
  • Peer Reviewed
• [Journal Article] Effects of amino acids on malarial heme crystallization. (2008)
  • Author(s): D. T. Uyen
  • Journal Title: Biol Pharm Bull. 31(8) Pages: 1483-1488
  • Peer Reviewed
• [Journal Article] 2-tert-Butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization (2007)
  • Author(s): N.T. Huy, K. Mizunuma, K. Kaur, K, Kaur, N.T.T.Nhien, M. Jain, D.T. Uyen, S. Harada, R. jain, and K. Kamei
  • Journal Title: Antimicrobial Agents and Chemotherapy 51(8) Pages: 2842-2847
  • Peer Reviewed
• [Journal Article] Alcohols induce beta-hematinformation via the dissociation of aggregated heme and reduction in interfacial tension of the solution (2007)
  • Author(s): N.T. Huy, A. Maeda, D.T. Uyen, D.T.X.Trang, M. Sasai, T.shiono, T.Oida, S. harada, and K. kamei
  • Journal Title: Acta Tropica 101(2) Pages: 130-138
  • Peer Reviewed
• [Journal Article] Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds (2007)
  • Author(s): Nguyen Tien Huy, Dinh Thanh Uyen, Atsushi Maeda, Dai Thi Xuan Trang, Tatsuo Oida, Shigeharau Harada, and Kaeko Kamei
  • Journal Title: Antimicrobial Agents and Chemotherapy 51(1) Pages: 350-353
  • Peer Reviewed
• [Journal Article] 8-Quinolinamines Containing 2-tert-buty1 Group Exhibits Potent Blood-schizontocidal Antimalarial Activities via Inhibition of the Heme Catabolism. (2007)
  • Author(s): N. T. Huy, K. Mizunuma, K. Kaur, N. T. T. Nhien, M. Jain, D. T. Uyen, S. Harada, R. Jain, and K. Kamei
  • Journal Title: Antimicrobial Agents and Chemotherapy, 51(8) Pages: 2842-2847
  • Peer Reviewed
• [Journal Article] Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution. (2007)
  • Author(s): N. T. Huy, A. Maeda, D. T. Uyen, D. T. X. Trang, M. Sasai, T. Shiono, T. Oida, S. Harada, and K. Kamei
  • Journal Title: Acta Tropica 101(2) Pages: 130-138
  • Peer Reviewed
• [Journal Article] Simple colorimetric inhibition assay of heme crystallization for high-throughput screening of antimalarial compounds. (2007)
  • Author(s): N. T. Huy, D. T. Uyen, A. Maeda, D. T. X. Trang, T. Oida, S. Harada, and K. Kamei
  • Journal Title: Antimicrobial Agents and Chemotherapy 51(1) Pages: 350-353
  • Peer Reviewed
• [Presentation] マラリア色素形成における脂質の役割 (2008)
  • Author(s): 前田篤志、N. T. Huy、水沼敬典、嶋祐介、笹井基裕、D. T. Uyen、N. T. T. Nhien、原田繁春、亀井加恵子
  • Organizer: 日本寄生虫学会
  • Place of Presentation: 長崎市
  • Year and Date: 2008-04-03