DNA vaccine targeting both liver and blood stage of virulent strain Plasmodium
| Project/Area Number |
19590429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Kyushu University |
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Principal Investigator |
HAMANO Shinjiro (2008) Kyushu University, 医学研究院, 助教 (70294915)
姫野 国祐 (2007) Kyushu University, 大学院・医学研究院, 教授 (50112339)
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| Co-Investigator(Kenkyū-buntansha) |
HIMENO Kunisuke 九州大学, 医学研究院, 教授 (50112339)
HISAEDA Hajime 九州大学, 医学研究院, 准教授 (50243689)
HIGO Hiroo 九州大学, 医学研究院, 助教 (80117225)
浜野 真二郎 九州大学, 大学院・医学研究院, 助教 (70294915)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | ユビキチン / プロテアソーム / マラリア / DNAワクチン / CD8^+T細胞 / 遺伝子銃 / マラリア強毒株 / ユビキチンプロテアソーム系 / 赤血球内型 / 肝臓内型 |
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| Research Abstract |
マウスマラリアP. yoelii 強毒株 (XL) のスポロゾイト感染系におけるUB-CSP とUB-MSP1によるキメラDNA ワクチンによって、マラリア虫血症および生存率の顕著な延長効果が認められ、P. yoelii XL に対する感染防御能の賦与が明らかとなった。
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells2008
Author(s)
Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
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Journal Title
J Immunol 180(4)
Pages: 2496-503
Related Report
Peer Reviewed
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[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.2008
Author(s)
Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K.
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Journal Title
J Immunol 180
Pages: 2496-503
Related Report
Peer Reviewed
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[Journal Article] Identification of Trypanosoma cruzi sublineages by the simple method of single-stranded conformation DNA polymorphism (SSCP)2007
Author(s)
Higo H, Miura S, Agatsuma T, Mimori T, Yanagi T, Iwagami M, de Arias AR, Matta V, Hirayama K, Takeuchi T, Tada I, HimenoK
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Journal Title
Parasitol Res 100(5)
Pages: 1023-31
Related Report
Peer Reviewed
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