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DNA vaccine targeting both liver and blood stage of virulent strain Plasmodium

Research Project

Project/Area Number 19590429
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionKyushu University

Principal Investigator

HAMANO Shinjiro (2008)  Kyushu University, 医学研究院, 助教 (70294915)

姫野 国祐 (2007)  Kyushu University, 大学院・医学研究院, 教授 (50112339)

Co-Investigator(Kenkyū-buntansha) HIMENO Kunisuke  九州大学, 医学研究院, 教授 (50112339)
HISAEDA Hajime  九州大学, 医学研究院, 准教授 (50243689)
HIGO Hiroo  九州大学, 医学研究院, 助教 (80117225)
浜野 真二郎  九州大学, 大学院・医学研究院, 助教 (70294915)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsユビキチン / プロテアソーム / マラリア / DNAワクチン / CD8^+T細胞 / 遺伝子銃 / マラリア強毒株 / ユビキチンプロテアソーム系 / 赤血球内型 / 肝臓内型
Research Abstract

マウスマラリアP. yoelii 強毒株 (XL) のスポロゾイト感染系におけるUB-CSP とUB-MSP1によるキメラDNA ワクチンによって、マラリア虫血症および生存率の顕著な延長効果が認められ、P. yoelii XL に対する感染防御能の賦与が明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (32 results)

All 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (15 results) Book (1 results)

  • [Journal Article] Concurrent infection with Heligmosomoides polygyrus modulates murine host response against Plasmodium berghei ANKA infection2008

    • Author(s)
      Tetsutani K, Ishiwata K, Torii M, Hamano S, Hisaeda H, Himeno K
    • Journal Title

      Am J Trop Med Hyg 79(6)

      Pages: 819-22

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of immunoproteasomes in the induction of protective immunity against Trypanosoma cruzi in mice vaccinated with a plasmid encoding a CTL epitope fused to green fluorescence protein2008

    • Author(s)
      Chou B, Hisaeda H, Shen J, Duan X, Imai T, Tu L, Murata S, Tanaka K, Himeno K
    • Journal Title

      Microbes Infect 10(3)

      Pages: 241-50

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells2008

    • Author(s)
      Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
    • Journal Title

      J Immunol 180(4)

      Pages: 2496-503

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-specific CD8^+ T cells induced by the ubiquitin fusion degradation pathway2008

    • Author(s)
      Imai T, Duan X, Hisaeda H, Himeno K
    • Journal Title

      Biochem Biophys Res Commun 365(4)

      Pages: 758-63

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin-fusion degradation pathway : a new strategy for inducing CD8 cells specific for mycobacterial HSP652008

    • Author(s)
      Shen J, Hisaeda H, Chou B, Yu Q, Tu L, Himeno K
    • Journal Title

      Biochem Biophys Res Commun 365(4)

      Pages: 621-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concurrent infection with Heligmosomoides polygyrus modulates murine host response against Plasmodium berghei ANKA infection.2008

    • Author(s)
      Tetsutani K, Ishiwata K, Torii M, Hamano S, Hisaeda H, Himeno K.
    • Journal Title

      Am J Trop Med Hyg 79

      Pages: 819-22

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of immunoproteasomes in the in duction of protective immunity against Trruzi in mice vaccinated with a plasmid encoding a CTL epitope fused to green fluorescence protein.2008

    • Author(s)
      Chou B, Hisaeda H, Shen J, Duan X, Imai T, Tu L, Murata S, Tanaka K, Himeno K.
    • Journal Title

      Microbes Infect 10

      Pages: 241-50

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.2008

    • Author(s)
      Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K.
    • Journal Title

      J Immunol 180

      Pages: 2496-503

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-specific CD8+T cells induced by the ubiquitin fusion degradation pathway.2008

    • Author(s)
      Imai T, Duan X, Hisaeda H, Himeno K.
    • Journal Title

      Biochem Biophys Res Commun 365

      Pages: 758-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin-fusion degradation pathway : a new strategy for inducing CD8 cells specific for mycobacterial HSP65.2008

    • Author(s)
      Shen J, Hisaeda H, Chou B, Yu Q, Tu L, Himeno K.
    • Journal Title

      Biochera Biophys Res Commun 10

      Pages: 241-50

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical contribution of immunoproteasomes in the induction of prptectivei immunity against Trypanosoma cruzi in mice vaccinated with a plasmid encoding a CTL epitope fused to green fluorescellce protein2008

    • Author(s)
      Chou B, et. al.
    • Journal Title

      Microbes and Infection 10(3)

      Pages: 241-250

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigen-specific CD8+T cells induced by the ubiquitin fusion degradation pathway2008

    • Author(s)
      Imai T., et. al.
    • Journal Title

      Biochem Biophys Res Common 365(4)

      Pages: 758-763

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ubiquitin-fusion degradation pathway:a new strategy for inducing CD8 cells specific for mycobacterial HSP652008

    • Author(s)
      Shen J., et. al.
    • Journal Title

      Biochem Biophys Res Commun 365(4)

      Pages: 621-627

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune therapy against tumors based on the ubiquitin-proteasome pathway2007

    • Author(s)
      Himeno K, Hisaeda H
    • Journal Title

      Fukuoka Igaku Zasshi(Review. Japanese) 98(8)

      Pages: 312-9

    • NAID

      120000987727

    • Related Report
      2008 Final Research Report
  • [Journal Article] Malaria parasite induces tryptophan-related immune suppression inmice2007

    • Author(s)
      Tetsutani K, To H, Torii M, Hisaeda H, Himeno K
    • Journal Title

      Parasitology 134(Pt7)

      Pages: 923-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Trypanosoma cruzi sublineages by the simple method of single-stranded conformation DNA polymorphism (SSCP)2007

    • Author(s)
      Higo H, Miura S, Agatsuma T, Mimori T, Yanagi T, Iwagami M, de Arias AR, Matta V, Hirayama K, Takeuchi T, Tada I, HimenoK
    • Journal Title

      Parasitol Res 100(5)

      Pages: 1023-31

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 消化管寄生虫感染が引き起こす免疫修飾の解析-マラリアとの共感染モデルを用いて2008

    • Author(s)
      鉄谷耕平
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      ブリックホール国際会議場、長崎
    • Year and Date
      2008-04-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic control of resistance to intestinal amebiasis in inbred mice2008

    • Author(s)
      濱野真二郎
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      ブリックホール国際会議場、長崎
    • Year and Date
      2008-04-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 変異ユビキチンを利用したユビキチン融合分解経路に基づくMHC-class I拘束性のCD8+T細胞の効率的な誘導2007

    • Author(s)
      今井 孝
    • Organizer
      第2回臨床ストレス応答学会大会
    • Place of Presentation
      九州大学
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] UFD経路によるmycobacterial HSP65に対するCD8T細胞の誘導2007

    • Author(s)
      段 学鋒
    • Organizer
      第2回臨床ストレス応答学会大会
    • Place of Presentation
      九州大学
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Application of ubiquitin fusion degradation pathway in DNA vaccination of Trypanosoma cruzi2007

    • Author(s)
      仇 斌
    • Organizer
      第2回臨床ストレス応答学会大会
    • Place of Presentation
      九州大学
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Apphcation of ubiquitin fusion degradation pathway in DNA vaccination against Trypanosoma cruzi2007

    • Author(s)
      Chou Bin
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Activation of regulatory T cells by dendritic cells in mice infected with malaria parasites2007

    • Author(s)
      Hisaeda Hajime
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪、東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Involvement of CD8+ T cells in protective immunity against murine malaria blood-stage infection2007

    • Author(s)
      IMAI Takashi
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪、東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Application of ubiquitin fusion degradation pathway in DNA vaccination against Trypanosoma cruzi2007

    • Author(s)
      Chou Bin
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪、東京
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] マラリア原虫によるToll-likereceptor 9 を介した制御性T 細胞の活性化2007

    • Author(s)
      久枝一
    • Organizer
      第76回日本寄生虫学会大会
    • Place of Presentation
      大阪大学
    • Year and Date
      2007-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Malaria parasite induces tryptophan related immune suppression in mice2007

    • Author(s)
      鉄谷耕平
    • Organizer
      第76回日本寄生虫学会大会
    • Place of Presentation
      大阪大学
    • Year and Date
      2007-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] マラリアの免疫抑制におけるヘモゾイン関与2007

    • Author(s)
      守家慈子
    • Organizer
      第76回日本寄生虫学会大会
    • Place of Presentation
      大阪大学
    • Year and Date
      2007-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスマラリア赤血球ステージ感染制御におけるCD8+T 細胞の関与2007

    • Author(s)
      今井孝
    • Organizer
      第76回日本寄生虫学会大会
    • Place of Presentation
      大阪大学
    • Year and Date
      2007-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] トキソプラズマの感染における免疫プロテアソームの関わり2007

    • Author(s)
      屠麗萍
    • Organizer
      第76回日本寄生虫学会大会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2007-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] PCRによるTrypanosoma cruziとT. rangeliの鑑別2007

    • Author(s)
      肥後廣夫
    • Organizer
      第76回日本寄生虫学会大会
    • Place of Presentation
      大阪大学
    • Year and Date
      2007-03-29
    • Related Report
      2008 Final Research Report
  • [Book] 寄生虫による病気in家庭の医学(第6版)2008

    • Author(s)
      濱野真二郎
    • Publisher
      保健同人社
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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