| Project/Area Number |
19590453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
|
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| Research Institution | Osaka City University |
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Principal Investigator |
FUJIWARA Nagatoshi Osaka City University, 大学院・医学研究科, 講師 (80326256)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Ikuya 日本ビーシージー製造株式会社, 中央研究所, 顧問 (60047008)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 感染免疫 / 脂質分子 / 宿主応答 / 結核菌 / ミコール酸 / 感染症 / 細菌 / 脂質 / 生理活性 / 免疫学 / 生活活性 |
|---|
| Research Abstract |
Mycolic acid is a characteristic cell wall component expressed in acid-fast bacteria containing Mycobacterium tuberculosis. The heterogeneity of mycolic acid subclasses (α, methoxy, keto, dicarboxy, epoxy, etc), unsaturations (monoene, diene, cyclopropane), and geometrical isomers (cis, trans) effected to cord forming, acid-fastness, and host immune responses to Mycobacteria. The modifications of mycolic acids play an important role in their virulence and pathogenecity.
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