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Modified mycolic acids in Mycobacterium tuberculosis regulate the host immune responses

Research Project

Project/Area Number 19590453
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionOsaka City University

Principal Investigator

FUJIWARA Nagatoshi  Osaka City University, 大学院・医学研究科, 講師 (80326256)

Co-Investigator(Kenkyū-buntansha) YANO Ikuya  日本ビーシージー製造株式会社, 中央研究所, 顧問 (60047008)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords感染免疫 / 脂質分子 / 宿主応答 / 結核菌 / ミコール酸 / 感染症 / 細菌 / 脂質 / 生理活性 / 免疫学 / 生活活性
Research Abstract

Mycolic acid is a characteristic cell wall component expressed in acid-fast bacteria containing Mycobacterium tuberculosis. The heterogeneity of mycolic acid subclasses (α, methoxy, keto, dicarboxy, epoxy, etc), unsaturations (monoene, diene, cyclopropane), and geometrical isomers (cis, trans) effected to cord forming, acid-fastness, and host immune responses to Mycobacteria. The modifications of mycolic acids play an important role in their virulence and pathogenecity.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (54 results)

All 2010 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (35 results) Book (3 results)

  • [Journal Article] Identification of Rhodococcus equi lipids recognized by host cytotoxic T-lymphocytes.2010

    • Author(s)
      S.P. Harris, N. Fujiwara, R.H. Mealey, D.C. Alperin, T. Naka, R. Goda, S.A. Hines
    • Journal Title

      Microbiology (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Rhodococcus equi lipids recognized by host cytotoxic T-lymphocytes.2010

    • Author(s)
      Harris, S.P.
    • Journal Title

      Microbiology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium kyorinense sp. nov., a novel slowly growing Mycobacterium sp. related to Mycobacterium celatum isolated from human clinical specimens.2009

    • Author(s)
      M. Okazaki, K. Ohkusu, H. Hata, H. Ohnishi, K. Sugawara, C. Kawamura, N. Fujiwara, S. Matsumoto, Y. Nishiuchi, K. Toyoda, H. Saito, S. Yonetani, Y. Fukugawa, M. Yamamoto, H. Wada, A. Sejimo, A. Ebina, H. Goto, T. Ezaki, T. Watanabe
    • Journal Title

      IJSEM 59

      Pages: 1336-1341

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparable Studies of Immunostimulating Activities In Vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) Sub-strains.2009

    • Author(s)
      D. Hayashi, T. Takii, N. Fujiwara, Y. Fujita, I. Yano, S. Yamamoto, M. Kondo, E. Yasuda, E. Inagaki, K. Kanai, A. Fujiwara, A. Kawarazaki, T. Chiba, K. Onozaki
    • Journal Title

      FEMS Immunol. Med. Microbiol 56

      Pages: 116-128

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ″Lysobacter enzymogenes subsp. cookii″Christensen 1 1978 should be recognized as an independent species Lysobacter cookii sp. nov.2009

    • Author(s)
      Y. Kawamura, J. Tomida, Y. Morita, T. Naka, S. Mizuno, N. Fujiwara
    • Journal Title

      FEMS Microbiol. Lett 298

      Pages: 118-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium kyorinense sp. Nov., a novel slowly growing Mycobacterium sp.related to Mycobacterium celatum isolated from human clinical specimens.2009

    • Author(s)
      Okazaki, M.
    • Journal Title

      Int. J.Syst. Evol. Microbiol. 59

      Pages: 1336-1341

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) sub-strains.2009

    • Author(s)
      Hayashi, D.
    • Journal Title

      FEMS Immunol. Med. Microbiol. 56

      Pages: 116-128

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Lysobacter enzymogenes subsp. cookii" Christensen 1 1978 should be recognized as an independent species Lysobacter cookii sp. nov.2009

    • Author(s)
      kawamura, Y.
    • Journal Title

      FEMS Microbiol. Lett. 298

      Pages: 118-123

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) sub-strains2009

    • Author(s)
      D. Hayashi
    • Journal Title

      FEMS Immunol. Med. Microbiol. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mycobacterium kyorinense sp. nov., a novel slowly growing Mycobacterium sp. related to Mycobacterium celatum isolated from human clinical specimens.2009

    • Author(s)
      M. Okazaki
    • Journal Title

      Int. J. Syst. Evol. Microbiol. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of two novel methyltransferase genes that determine the serotype 12-specific structure of glycopeptidolipids of Mycobacterium intracellulare.2008

    • Author(s)
      N. Nakata, N. Fujiwara, T. Naka, I. Yano, K. Kobayashi, S. Maeda
    • Journal Title

      J. Bacteriol 190

      Pages: 1064-1071

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural analysis and biosynthesis gene cluster of an antigenic glycopeptidolipid from Mycobacterium intracellulare.2008

    • Author(s)
      N. Fujiwara, N. Nakata, T. Naka, I. Yano, M. Doe, D. Chatterjee, M. McNeil, P.J. Brennan, K. Kobayashi, M. Makino, S. Matsumoto, H. Ogura, S. Maeda
    • Journal Title

      J. Bacteriol 190

      Pages: 3613-3621

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural analysis and biosynthesis gene cluster of an antigenic glycopeptidolipid from Mycobacterium intracellulare2008

    • Author(s)
      N. Fujiwara
    • Journal Title

      Journal of Bacteriology 190

      Pages: 1063-1071

    • Related Report
      2008 Annual Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of two novel methyltransferase genes that determine the serotype 12-specific structure of glycopeptidolipids of Mycobacterium intracellulare.2008

    • Author(s)
      N. Nakata
    • Journal Title

      Journal of Bacteriology 190

      Pages: 1064-1071

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of cell wall assembly by a histone-like protein in mycobacteria.2007

    • Author(s)
      T. Katsube, S. Matsumoto, M. Takatsuka, M. Okuyama, Y. Ozeki, M. Naito, Y. Nishiuchi, N. Fujiwara, M. Yoshimura, T. Tsuboi, M. Torii, N. Oshitani, T. Arakawa, K. Kobayashi
    • Journal Title

      J. Bacteriol 189

      Pages: 8241-8249

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of cell wall assembly by a histone-like protein in mycobacteria.2007

    • Author(s)
      T. Katsube
    • Journal Title

      Journal of Bacteriology 189

      Pages: 8241-8249

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] kasB結核菌の透過電子顕微鏡観察2010

    • Author(s)
      山田博之
    • Organizer
      第34回日本顕微鏡学会関東支部会
    • Place of Presentation
      帝京大学医学部板橋キャンパス(東京)
    • Year and Date
      2010-03-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mycobacterium smegmatis株間の脂質分布と脂質成分による宿主応答の差異2010

    • Author(s)
      藤原永年, 野本摩利, 中崇, 合田麗奈, 小川みどり, 水野淨子, 小林貴美子, 谷口初美
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Mycobacterium avium complex血清型4型株におけるglycopeptidolipidの生合成解析2010

    • Author(s)
      宮本友司, 向井徹, 甲斐雅規, 前田百美, 中崇, 藤原永年, 水野淨子, 矢野郁也, 牧野正彦
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Mycobacterium smegmatis株間の脂質の分布と脂質成分による宿主応答の差異2010

    • Author(s)
      藤原永年
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mycobacterium avium complex血清型4型株におけるglycopeptidolipidの生合成解析2010

    • Author(s)
      宮本友司
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structures and host recognitions of antigenic serotype 7, 13 glycopeptidolipids from Mycobacterium intracellulare.2009

    • Author(s)
      N. Fujiwara, T. Naka, R. Goda, S. Mizuno, M. Yoshimura, S. Matsumoto, H. Ogura, S. Maeda
    • Organizer
      Infection 2009
    • Place of Presentation
      Birmingham, UK
    • Related Report
      2009 Final Research Report
  • [Presentation] MAC血清型13型菌由来糖ペプチド脂質の構造修飾と宿主応答2009

    • Author(s)
      合田麗奈, 中崇, 前田伸司, 水野淨子, 小林貴美子, 藤原永年
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Rhodococcus equi - immunity and strategies for prevention.2009

    • Author(s)
      S.A. Hines, S.P. Harris. N. Fujiwara, R.H. Mealey, R.G. Dossa, D.C. Alperin
    • Organizer
      The 5th International Veterinary Vaccines and Diagnostics Conference (IVVDC)
    • Place of Presentation
      Madison, WI USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Mycobacterium avium TMC724SのpH依存的な集落形成の違いと免疫応答、薬剤感受性、細胞壁形成との相関2009

    • Author(s)
      山本龍二, 堀田康弘, 菅原勇, 藤原永年, 伊藤佐生智, 瀧井猛将
    • Organizer
      第84回日本結核病学会総会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] Mycobacterium intracellulare由来血清型7, 12, 13型糖ペプチド脂質の構造類似性とオリゴ糖解析2009

    • Author(s)
      藤原永年, 中田登, 中崇, 水野淨子, 牧野正彦, 松本壮吉, 前田伸司
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Mycobacterium avium TMS724SのpH依存的形態変化に関する研究2009

    • Author(s)
      堀田康弘, 瀧井猛将, 菅原勇, 藤原永年, 山本龍二, 稲垣衣美, 小野嵜菊夫
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Mycobacterium bovis BCG亜株間の自然免疫誘導活性の差異とミコール酸の関与2009

    • Author(s)
      林大介, 安田恵実, 瀧井猛将, 藤原永年, 山本三郎, 矢野郁也, 小野嵜菊夫
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] BCG菌のミコール酸サブクラス合成遺伝子の解析2009

    • Author(s)
      甲斐雅規, 藤原永年, 宮本友司, 向井徹, 矢野郁也, 牧野正彦
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Rhodococcus equi-immunity and strategies for prevention2009

    • Author(s)
      Hines, S.A.
    • Organizer
      The 5th International Veterinary Vaccines and Diagnostics Conference (IVVDC)
    • Place of Presentation
      Madison, WI, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Structures and host recognitions of antigenic serotype 7, 13 glycopeptidolipids from Mycobacterium intracellulare2009

    • Author(s)
      Fujiwara, N.
    • Organizer
      Infection 2009
    • Place of Presentation
      Birmingham, UK.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mycobacterium avium TMC724SのpH依存的な集落形成の違いと免疫応答、薬剤感受性、細胞壁形成との相関2009

    • Author(s)
      山本龍二
    • Organizer
      第84回日本結核病学会総会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Related Report
      2009 Annual Research Report
  • [Presentation] MAC血清型13型菌由来糖ペプチド脂質の構造修飾と宿主応答2009

    • Author(s)
      合田麗奈
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mycobacterium intracellulare serotype13 由来新規特異糖ペプチド脂質の糖鎖構造と生合成2008

    • Author(s)
      藤原永年
    • Organizer
      第81回日本生化学会大会 第31回日本分子生物学会年会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Three methyltransferase genes determine the divergence between Mycobacterium intracellulare serotypes 7 and 122008

    • Author(s)
      N. Nakata
    • Organizer
      108^<th> General Meeting, The American Society for Microbiology
    • Place of Presentation
      Boston, USA
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic analysis of the glycosylation pathway of glycopeptidolipids in Mycobacterium intracellulare serotype 16 and serotype 172008

    • Author(s)
      S. Maeda
    • Organizer
      108^<th> General Meeting, The American Society for Microbiology
    • Place of Presentation
      Boston, USA
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Structure and biosynthesis gene cluster of an antigenic serotype 16 glycopeptidolipid from Mycobacterium intracellulare2008

    • Author(s)
      N. Fujiwara
    • Organizer
      108^<th> General Meeting, The American Society for Microbiology
    • Place of Presentation
      Boston, USA
    • Year and Date
      2008-06-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mycobacterial DNA-binding protein 1(MDP1)による増殖と細胞壁合成の同調メカニズム2008

    • Author(s)
      松本壮吉
    • Organizer
      第83回日本結核病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mycobacterium bovis BCG亜株間の生化学的、物理化学的性質と生物学的活性の比較研究2008

    • Author(s)
      瀧井猛将
    • Organizer
      第83回日本結核病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-04-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mycobacterium intracellulare由来血清型7,12型glycopeptidolipid糖鎖合成遺伝子の機能解析2008

    • Author(s)
      藤原 永年
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mycobacterium intracellular血清型12のglycopeptidolipid生合成遺伝子領域の解析2008

    • Author(s)
      中田 登
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mycobacterium intracellulare serotype 13由来新規特異糖ペプチド脂質の糖鎖構造と生合成2008

    • Author(s)
      水野淨子, 中崇, 中田登, 前田伸司, 合田麗奈, 小林貴美子, 牧野正彦, 藤原永年
    • Organizer
      第81回日本生化学会大会第31回日本分子生物学会年会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] Structure and biosynthesis gene cluster of an antigenic serotype 16 glycopeptidolipid from Mycobacterium intracellulare. 108th General Meeting2008

    • Author(s)
      N. Fujiwara, N. Nakata, T. Naka, I. Yano, K. Kobayashi, M. Makino, S. Matsumoto, M. Yoshimura, S. Maeda
    • Organizer
      The American Society for Microbiology
    • Place of Presentation
      Boston USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Three methyltransferase genes determine the divergence between Mycobacterium intracellulare serotypes 7 and 12.2008

    • Author(s)
      N. Nakata, N. Fujiwara, S. Maeda, T. Naka, I. Yano, M. Makino
    • Organizer
      108th General Meeting, The American Society for Microbiology
    • Place of Presentation
      Boston USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetic analysis of the glycosylation pathway of glycopeptidolipids in Mycobacterium intracellulare serotype 16 and serotype 17.2008

    • Author(s)
      S. Maeda, N. Nakata, T. Naka, I. Yano, M. Makino, N. Fujiwara
    • Organizer
      108th General Meeting, The American Society for Microbiology
    • Place of Presentation
      Boston USA
    • Related Report
      2009 Final Research Report
  • [Presentation] BCG亜株の脂質生化学的比較研究2008

    • Author(s)
      藤原永年, 松本壮吉, 瀧井猛将, 藤田由希子, 矢野郁也, 前田伸司, 山本三郎
    • Organizer
      第83回日本結核病学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Mybacterium bovis BCG亜株間の生化学的、物理化学的性質と生物学的活性の比較研究2008

    • Author(s)
      瀧井猛将, 藤原永年, 矢野郁也, 山本三郎
    • Organizer
      第83回日本結核病学会総会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Mycobacterium intracellulare由来血清型7, 12型glycopeptidolipid糖鎖合成遺伝子の機能解析2008

    • Author(s)
      藤原永年, 中田登, 前田伸司, 中崇, 水野淨子, 牧野正彦, 松本壮吉, 矢野郁也
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Mycobacterium intracellulare血清型12のglycopeptidolipid生合成遺伝子領域の解析2008

    • Author(s)
      中田登, 藤原永年, 前田伸司, 中崇, 矢野郁也, 小林和夫, 牧野正彦
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Structural analysis of sphingoglycolipid from Basidiomycota2007

    • Author(s)
      S. Mizuno, T. Naka, K. Kobayashi, M. Doe, S. Maeda, N. Fujiwara
    • Organizer
      第80回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] ミコール酸分子種の異なるcord factorの宿主応答2007

    • Author(s)
      藤原永年, 前田伸司, 矢野郁也, 松本壮吉, 小林和夫
    • Organizer
      第82回日本結核病学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Book] Mycobacterial glycolipids and host responses(E. Sasaki (ed.))2008

    • Author(s)
      N. Fujiwara, K. Kobayashi
    • Publisher
      Nova Science Publishers
    • Related Report
      2009 Final Research Report
  • [Book] KEY WORD感染症[第2版](山口恵三・戸塚恭一(編))2008

    • Author(s)
      前田伸司, 藤原永年
    • Publisher
      先端医学社
    • Related Report
      2009 Final Research Report
  • [Book] Mycobacterial glycolipids and host responses, In E. Sasaki (ed. ), Glycolipids : New Research.(Chapter IV)2008

    • Author(s)
      N. Fujiwara
    • Publisher
      Nova Science Publishers, Inc., Hauppauge NY.
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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