Ribosome-binding dependent induction of translational suppression and acquiring drug resistance caused by M. tuberculosis protein, MDP1
Project/Area Number |
19590454
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Osaka City University |
Principal Investigator |
0MATSUMOTO Sohkichi Osaka City University, 大学院・医学研究科, 准教授 (30244073)
|
Co-Investigator(Kenkyū-buntansha) |
YOSHIMURA Mamiko 大阪市立大学, 大学院・医学研究科, 助教 (20438229)
和田 崇之 大阪市立環境科学研究所, 微生物保健科, 研究員 (70332450)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 潜伏感染 / 薬剤耐性 / 抗酸菌 / リボゾーム / 結核 / 感染症 / 翻訳 / 細菌 |
Research Abstract |
抗酸菌に特異的なヒストン様蛋白質であるMycobacterial DNA-binding protein 1 (MDP1)の薬剤感受性にかかわる作用を調べた。その結果、MDP1は抗酸菌の薬剤感受性に関わることが判明した。この作用はMDP1分子による直接的な薬剤の競合阻害ではなく、リボゾームに結合することによって生じる構造変化や、複数の薬剤代謝経路を遺伝子発現を介して制御する作用によるものであると推察された。
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Report
(3 results)
Research Products
(49 results)
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[Journal Article] Virulence of Mycobacterium avium complex strains isolated fromimmunocompetent patients2009
Author(s)
Tateishi, Y., Y. Hirayama, Y. Ozeki, Y. Nishiuchi, M. Yoshimura, J. Kang, A. Shibata, K. Hirata, S. Kitada, R. Maekura, H. Ogura, K. Kobayashi, and S. Matsumoto
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Journal Title
Microb Pathog 46
Pages: 6-12
Related Report
Peer Reviewed
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[Journal Article] Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium2008
Author(s)
Saiga, H., J. Nishimura, H. Kuwata, M. Okuyama, S. Matsumoto, S. Sato, M. Matsumoto, S. Akira, Y. Yoshikai, K. Honda, M. Yamamoto, and K. Takeda
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Journal Title
J Immunol 181
Pages: 8521-8527
Related Report
Peer Reviewed
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[Journal Article] Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor2008
Author(s)
Nishimura, J., H. Saiga, S. Sato, M. Okuyama, H. Kayama, H. Kuwata, S. Matsumoto, T. Nishida, Y. Sawa, S. Akira, Y. Yoshikai, M. Yamamoto, and K. Takeda
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Journal Title
J Immunol 180
Pages: 4032-4039
Related Report
Peer Reviewed
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[Journal Article] Structural analysis and biosynthesis gene cluster of an antigenic glycopeptidolipid from Mycobacterium intracellulare2008
Author(s)
Fujiwara, N., N. Nakata, T. Naka, I. Yano, M. Doe, D. Chatterjee, M. McNeil, P. J. Brennan, K. Kobayashi, M. Makino, S. Matsumoto, H. Ogura, and S. Maeda
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Journal Title
J Bacteriol 190
Pages: 3613-3621
Related Report
Peer Reviewed
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[Journal Article] Control of cell wall assembly by a histone-like protein in Mycobacteria2007
Author(s)
Katsube, T., S. Matsumoto, M. Takatsuka, M. Okuyama, Y. Ozeki, M. Naito, Y. Nishiuchi, N. Fujiwara, M. Yoshimura, T. Tsuboi, M. Torii, N. Oshitani, T. Arakawa, and K. Kobayashi
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Journal Title
J Bacteriol 189
Pages: 8241-8249
Related Report
Peer Reviewed
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[Journal Article] Mycobacterium kyorinense sp. nov., a novel slowly growing Mycobact- erium sp. related to Mycobacterium celatum isolated from three patients with infections
Author(s)
Okazaki M, Ohnishi H, Ohkusu K, Hata H, Fujiwara N, Matsumoto S, Nishiuchi Y, Yonetani S, Fukugawa Y, Yamamoto M, Wada H, Sugawara K, Sejimo A, Kawamura C, Ebina A, Ezaki T, Goto H, and Watanabe T.
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Journal Title
Int J Syst Evol Microbiol (in press)
Related Report
Peer Reviewed
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