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Characterization of dermal allergic murine models induce by repeated application of non protein substance from pathogenic fungi.

Research Project

Project/Area Number 19590459
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

ADACHI Yoshiyuki  Tokyo University of Pharmacy and Life Science, 薬学部, 准教授 (60222634)

Co-Investigator(Kenkyū-buntansha) 大野 尚仁  東京薬科大学, 薬学部, 教授 (80152213)
三浦 典子  東京薬科大学, 薬学部, 講師 (30218036)
Co-Investigator(Renkei-kenkyūsha) OHNO Naohito  東京薬科大学, 薬学部, 教授 (80152213)
MIURA Noriko  東京薬科大学, 薬学部, 講師 (30218036)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsカンジダ / β-グルカン / アトピー性皮膚炎 / Th2 / dectin-1 / CR3
Research Abstract

The effect of fungal beta-glucan (BG) on the allergic dermatitis, animal model using tape-stripping and BG-painting model on mice were examined. Repeated application of Candida-derived BG and antigen accelerated the inflammation in skin tissue. Characterization of BG receptors concerning the BG-induced inflammation suggested that complement receptors support BG-recognition and the immune cell activation induced by dectin-1-mediated cell activity.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Dissociation of Toll-like receptor 2-mediated innate immune response to Zymosan by organic solvent-treatment without loss of Dectin-1 reactivity2008

    • Author(s)
      Ikeda Yoshihiko, Adachi Yoshiyuki, Ishii Takashi, Miura Noriko, Tamura Hiroshi, Ohno Naohito.
    • Journal Title

      Biol Pharm Bull. 31巻

      Pages: 13-18

    • NAID

      110006569967

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of rat beta-glucan receptor dectin-12008

    • Author(s)
      Kato Yuya, Adachi Yoshiyuki, Ohno Naohito
    • Journal Title

      Microbiol Immunol. 52巻

      Pages: 418-428

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dissociation of Toll-like receptor 2-mediated innate immune response to Zymosan by organic solvent-treatment without loss of Dectin-1 reactivity2008

    • Author(s)
      Yoshihiko Ikeda、, et. al.
    • Journal Title

      Biol Pharm Bull. 31

      Pages: 13-18

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] (1→3)-β-D-グルカンの免疫賦活活性とデクチンー1、かがわ糖質バイオフォーラム2009

    • Author(s)
      安達禎之
    • Organizer
      第1回複合糖質研究会
    • Place of Presentation
      香川県高松市
    • Year and Date
      2009-09-02
    • Related Report
      2009 Final Research Report
  • [Presentation] (1→3)-β-D-グルカンの免疫賦活活性とデクチンー12009

    • Author(s)
      安達禎之
    • Organizer
      かがわ糖質バイオフォーラム 第1回 複合糖質研究会
    • Place of Presentation
      香川県高松市
    • Year and Date
      2009-09-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 病原性真菌多糖による皮膚炎増悪作用の解析2009

    • Author(s)
      青木厚介、安達禎之、山口敦子、石橋健一、三浦典子、新槇幸彦、大野尚仁
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2009-03-26
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 接触性皮膚炎モデルマウスにおける真菌β-グルカンの影響2008

    • Author(s)
      青木厚介、安達禎之、大野尚仁
    • Organizer
      第52回日本医真菌学会総会
    • Place of Presentation
      長崎県長崎市
    • Year and Date
      2008-09-12
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] IgE介在性の脱顆粒反応における真菌β-グルカンの影響2007

    • Author(s)
      青木厚介、安達禎之、大野尚仁
    • Organizer
      第51回日本医真菌学会総会
    • Place of Presentation
      岐阜県高山市
    • Year and Date
      2007-11-09
    • Related Report
      2009 Final Research Report
  • [Presentation] IgE介在性の脱顆粒反応における真菌β-グルカンの影響2007

    • Author(s)
      青木厚介, ら
    • Organizer
      第51回 日本医真菌学会総会
    • Place of Presentation
      岐阜県高山市
    • Year and Date
      2007-11-09
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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