Adeno-associate virus (AAV) induces apoptosis of HIV-infected cells
Project/Area Number |
19590481
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Virology
|
Research Institution | Yokohama City University |
Principal Investigator |
SHIMADA Masaru Yokohama City University, 医学部, 准教授 (40301452)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | AAV / HIV / アポトーシス / アデノ随伴ウイルス(AAV) / 感染細胞 |
Research Abstract |
現在のエイズ治療の主流であるHAARTの問題点の一つとして、この治療法に用いられる逆転写酵素阻害剤・プロテアーゼ阻害剤等の薬剤は、HIVの増殖を抑制できるがHIV感染細胞自体は排除できないことが挙げられる。そこで、本研究ではヘキソンを改変したAAVを使用したHIV感染細胞特異的アポトーシスを誘導することを目的とした
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 52009
Author(s)
Abe, S., Okuda, K., Ura, T., Kondo, A., Yoshida, A., Yoshizaki, S., Mizuguchi, H., Klinman, D., Shimada, M.
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Journal Title
J. Gene Med. 11巻
Pages: 570-579
Related Report
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[Journal Article] Effect of therapeutic immunization using Ad5/35 and MVA vectors on SIV-infection of rhesus monkeys undergoing anti-retroviral therapy2009
Author(s)
Shimada, M., Wang, H-B., Kondo, A., Xu, X-P., Yoshida, A., Ura, T., Mizuguchi ,H., Klinman, D., Luo, J-L., Bai, H., Okuda, K.
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Journal Title
Gene Ther 16巻
Pages: 218-228
Related Report
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[Journal Article] Designed Recombinant Adenovirus Type 5 Vector Induced Env-specific CD8+ Cytotoxic T lymphocytes and Cross-reactive Neutralizing Antibodies against Human Immunodeficiency Virus Type 12009
Author(s)
Ura, T., Yoshida, A., K-Q, Xin., Yoshizaki, S., Yashima, S., Abe, S., Mizuguchi, H., Okuda,K.
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Journal Title
J. Gene Med 11巻
Pages: 139-149
Related Report
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[Journal Article] Effect of therapeutic immunization using Ad5/35 and MVA vectors on SIV-infection of rhesus monkeys undergoing anti-retroviral therapy.2009
Author(s)
Shimada. M., Wang, H-B., Kondo, A., Xu, X-P., Yoshida, A., Ura, T., Mizuguchi, H., Klinman, D., Luo, J-L., Bai, H., Okuda, K.
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Journal Title
Gene Ther. 16
Pages: 218-228
Related Report
Peer Reviewed
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[Journal Article] Designed Recombinant Adenovirus Type 5 Vector Induced Env-specific CD8+ Cytotoxic T lymphocytes and Cross-reactive Neutralizing Antibodies against Human Immunodeficiency Virus Type1.2009
Author(s)
Ura, T., Yoshida, A., K-Q, Xin., Yoshizaki, S., Yashima, S., Abe, S., Mizuguchi, H., Okuda, K.
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Journal Title
J. Gene Med 11
Pages: 139-149
Related Report
Peer Reviewed
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[Journal Article] The Atg5 Atg12 conjugate associates with innate antiviral immune responses2007
Author(s)
Jounai, N., Takeshita, F., Kobiyama, K., Sawano, A., Miyawaki, A., Shimada, M., Ishii, KJ, Kawai, T., Akira, S., Suzuki, K., Okuda, K.
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Journal Title
PNAS 104巻
Pages: 4050-4055
Related Report
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[Journal Article] Chimeric adenovirus type 5/35 vector encoding SIV gag and HIV env genes affords protective immunity against the simian/human immunodeficiency virus in monkeys.2007
Author(s)
Someya, K., Shimada, M.., Ami, Y., Izumi, Y., Mizuguchi, H., Ohta, S., Yamamoto, N., Honda, M., Okuda, K.
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Journal Title
Virology 367巻
Pages: 390-397
Related Report
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[Journal Article] Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine2007
Author(s)
Saha, S., Takeshita, F., Matsuda, T., Jounai, N., Kobiyama, K., Matsumoto, T., Sasaki, S., Yoshita, A., Shimada, M.., Klinmana, D.M., Uematsu, S., Ishii, KJ, Akira, S., Okuda, K.
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Journal Title
J. Immunol 179巻
Pages: 1147-1154
Related Report
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[Journal Article] Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV2007
Author(s)
Shimada, M., Sekimoto, Y., Takahashi, T., Mizuguchi, H., Ichino, M., Yoshida, A. Okuda, K.
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Journal Title
Vaccine 25巻
Pages: 3809-3815
Related Report
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[Journal Article] The degree of apoptosis as an immunostimulant for a DNA vaccine against HIV-1 infection2007
Author(s)
Kojima, Y., Jounai, N., Takeshita, F., Nakazawa, M., Okuda, K., Watabe, S., Shimada, M., Okuda, K.
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Journal Title
Vaccine 25巻
Pages: 438-45
Related Report
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[Journal Article] Isolation and identification of adenovirus from conjunctival scrapings over a two-year period (between 2001 and 2003) in Yokohama, Japan2007
Author(s)
Matsui, K., Saha, S., saitoh, M., Mizuki, N., Itoh, N., Okada, E., Yashida, A., Shimada, M., Nishio, O., Okuda, K.
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Journal Title
J. Med. Virol 79巻
Pages: 200-205
Related Report
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[Journal Article] Adenovirus type 5 with modified hexons induces robust trans gene-specific immune responses in mice with pre-existing immunity against adenovirus type 5.
Author(s)
Abe, S., Okuda, K., Ura, T., Kond o, A., Yoshida, A., Yoshizaki, S., Mizuguchi, H., Klinman, D., Shimada. M.
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Journal Title
Related Report
Peer Reviewed
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