• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

HIV integration and lymphomagenesis

Research Project

Project/Area Number 19590485
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

KATANO Harutaka  National Institute of Infectious Diseases, 感染病理部, 室長 (70321867)

Co-Investigator(Renkei-kenkyūsha) SATA Tetsutaro  国立感染症研究所, 感染病理部, 部長 (00162397)
KANNO Takayuki  国立感染症研究所, 感染病理部, 主任研究官 (50272563)
NAKAMURA Tomoyuki  国立感染症研究所, 感染病理部, 研究生
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsHIV / インテグレーション / リンパ腫 / STAT3
Research Abstract

ヒト免疫不全ウイルス(HIV)の宿主細胞へのインテグレーションとリンパ腫発症との関連について、エイズ関連リンパ腫20例を検索した。HIVインテグレーションが示唆されたのは1例のみで、リンパ腫発症との関連は不明であった。これにより、エイズ関連リンパ腫ではHIVインテグレーションはまれであることが分かった。また、エイズ関連リンパ腫では一般にSTAT3の発現が亢進していることが明らかになった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 5 results) Presentation (11 results)

  • [Journal Article] Human herpes virus 6 encephalomyelitis after bone marrow Int J Cancer. transplantation : eport of an autopsy case.2009

    • Author(s)
      Shintaku M, Kaneda D, Tada K, Katano H, Sata T.
    • Journal Title

      Neuropathology in press

      Pages: 0-0

    • Related Report
      2008 Final Research Report
  • [Journal Article] An HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells.2009

    • Author(s)
      Dewan MZ, Tomita M, Katano H, Yamamoto N, Ahmed S, Yamamoto M, Sata T, Mori N, Yamamoto N.
    • Journal Title

      Int J Cancer. 124

      Pages: 622-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Human herpes virus 6 encephalomyelitis after bone marrow transplantation : Report of an autopsy case2009

    • Author(s)
      Shintaku M, Kaneda D, Tada K, Katano H, Sata T.
    • Journal Title

      Neuropathology (印刷中)

    • NAID

      10029319935

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells.2009

    • Author(s)
      Dewan MZ, Tomita M, Katano H, Yamamoto N, Ahmed S, Yamamoto M, Sata T, Mori N, Yamamoto N.
    • Journal Title

      Int J Cancer 124

      Pages: 622-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a 1.6 kb genome locus of guinea pig cytomegalovirus required for efficient viral growth in animals but not in cell culture.2008

    • Author(s)
      Nozawa N, Yamamoto Y, Fukui Y, Katano H, Tsutsui Y, Sato Y, Yamada S, Inami Y, Nakamura K, Yokoi M, Kurane I, Inoue N.
    • Journal Title

      Virology. 379

      Pages: 45-54

    • Related Report
      2008 Final Research Report
  • [Journal Article] H5N1-Infected Cells in Lung with Diffuse Alveolar Damage in Exudative Phase from a Fatal Case in Vietnam.2008

    • Author(s)
      Liem NT, Nakajima N, Phat LP, Sato Y, Thach HN, Hung PV, San LT, Katano H, Kumasaka T, Oka T, Kawachi S, Matsushita T, Sata T, Kudo K, Suzuki K.
    • Journal Title

      Jpn J Infect Dis. 61

      Pages: 157-60

    • Related Report
      2008 Final Research Report
  • [Journal Article] Critical role for TSLC1 expression in the growth and organ infiltration of adult T-cell leukemia cells in vivo.2008

    • Author(s)
      Dewan MZ, Takamatsu N, Hidaka T, Hatakeyama K, Nakahata S, Fujisawa J, Katano H, Yamamoto N, Morishita K.
    • Journal Title

      J Virol. 82

      Pages: 11958-63

    • Related Report
      2008 Final Research Report
  • [Journal Article] Critical role for TSLCl expression in the growth and organ infiltration of adult T-cell leukemia cells in vivo2008

    • Author(s)
      Dewan MZ, Takamatsu N, Hidaka T, Hatakeyama K, Nakahata S, Fujisawa J, Katano H, Yamamoto N, Morishita K.
    • Journal Title

      J Virol 82

      Pages: 11958-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma: successful treatment with interferon-alpha.2007

    • Author(s)
      Ueno T, Mitsuishi T, Kimura Y, Kato T, Hasegawa H, Katano H, Sata T, Kurane S, Kawana S.
    • Journal Title

      Eur J Dermatol. 17

      Pages: 539-40

    • Related Report
      2008 Final Research Report
  • [Journal Article] Rapid detection of human herpesvirus 8 DNA using loop-mediated isothermal amplification.2007

    • Author(s)
      Kuhara T, Yoshikawa T, Ihira M, Watanabe D, Tamada Y, Katano H, Asano Y, Matsumoto Y.
    • Journal Title

      J Virol Methods. 144

      Pages: 79-85

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Journal Article] Pathogenesis of cytomegalovirus-associated labyrinthitis in a guinea pig model.2007

    • Author(s)
      Katano H, Sato Y, Tsutsui Y, Sata T, Maeda A, Nozawa N, Inoue N, Nomura Y, Kurata T.
    • Journal Title

      Microbes Infect 9

      Pages: 183-91

    • Related Report
      2008 Final Research Report
  • [Journal Article] Weiden MD, Hoshino Y. Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient.2007

    • Author(s)
      Katano H, Sato Y, Hoshino S, Tachikawa N, Oka S, Morishita Y, Ishida T, Watanabe T, Rom WN, Mori S, Sata T
    • Journal Title

      Microbes Infect. 9

      Pages: 1581-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Vallinoto AC, Ishak R. High diversity of HHV-8 molecular subtypes in the Amazon region of Brazil: Evidence of an ancient human infection.2007

    • Author(s)
      Ishak Mde O, Martins RN, Machado PR, de Souza LL, Machado LF, Azevedo VN, Katano H, Sata T, Hasegawa H
    • Journal Title

      J Med Virol. 79

      Pages: 1537-44

    • Related Report
      2008 Final Research Report
  • [Journal Article] Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient.2007

    • Author(s)
      Katano H, Sato Y, Hoshino S, Tachikawa N, Oka S, Morishita Y, Ishida T, Watanabe T, Rom WN, Mori S, Sata T, Weiden MD, Hoshino Y.
    • Journal Title

      Microbes Infect. 9

      Pages: 1581-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathogenesis of cytomegalovirus-associated labyrinthitis in a guinea pig model.2007

    • Author(s)
      Katano H, Sato Y, Tsutsui Y, Sata T, Maeda A, Nozawa N, Inoue N, Nomura Y, Kurata T.
    • Journal Title

      Microbes Infect. 9

      Pages: 183-91

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] エイズ関連リンパ腫およびエイズ剖検例の各臓器における多種類ウイルスの定量.2008

    • Author(s)
      片野晴隆、佐多徹太郎
    • Organizer
      第22回日本エイズ学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] KSHV感染におけるKSHV全遺伝子発現プロファイルの解析2008

    • Author(s)
      片野晴隆、中村智之、菅野隆行、佐藤由子、佐多徹太郎
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Related Report
      2008 Final Research Report
  • [Presentation] RTA発現レベルの異なるKSHV感染細胞におけるウイルス感染維持2008

    • Author(s)
      菅野隆行、佐多徹太郎、片野晴隆
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Related Report
      2008 Final Research Report
  • [Presentation] 定量的PCRによる網羅的ウイルス検出法の開発とエイズ剖検例の各臓器におけるウイルス感染プロファイルの解析2008

    • Author(s)
      片野晴隆、加納基史、中村智之、菅野隆行、浅沼秀樹、佐多徹太郎
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 定量的PCRによる網羅的ウイルス検出法の開発とエイズ剖検例の各臓器におけるウイルス感染プロファイル2008

    • Author(s)
      片野晴隆、菅野隆行、佐多徹太郎
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] エイズ関連リンパ腫およびエイズ剖検例の各臓器における多種類ウイルスの定量2008

    • Author(s)
      片野晴隆, 佐多徹太郎
    • Organizer
      第22回日本エイズ学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] エイズ関連悪性腫瘍の感染病理に関する研究.2007

    • Author(s)
      片野 晴隆
    • Organizer
      第53回日本病理学会秋期特別総会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] エイズ関連悪性腫瘍の感染病理に関する研究2007

    • Author(s)
      片野晴隆
    • Organizer
      第53回日本病理学会秋期特別総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] エイズ剖検例の各臓器におけるDNAウイルスの感染プロファイル2007

    • Author(s)
      片野晴隆、加納基史、菅野隆行、佐多徹太郎
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] サイトカインによるカポジ肉腫関連ヘルペスウイルス(KSHV)遺伝子の誘導2007

    • Author(s)
      菅野隆行、佐多徹太郎、片野晴隆
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] エイズ剖検例の各臓器におけるヒトヘルペスウイルスの定量2007

    • Author(s)
      片野晴隆、加納基史、菅野隆行、佐多徹太郎
    • Organizer
      第22回ヘルペスウイルス研究会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi