Crucial role for CD69 in the development of inflammation

• Project/Area Number: 19590491
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Yamaguchi University (2008); Chiba University (2007)
• Principal Investigator: HASEGAWA Akihiro Yamaguchi University, 大学院・医学系研究科, 講師 (80376376)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 接着分子 / CD69 / 喘息 / 炎症 / コレセプター / 腸炎 / 免疫学

Research Abstract

CD69分子は早期活性化マーカー分子としてリンパ球の活性化の指標として広く用いられているが、機能の詳細は明らかにされていない。本研究では、アレルギー性喘息および腸炎モデルを用いてCD69分子の役割とその発現様式に関する解析を行った。その結果、炎症部位に浸潤しているほとんどの炎症細胞でCD69の発現が見られ、CD69ノックアウトマウスではアレルギー性喘息や腸炎が起こらないことが明らかとなった。さらにこれらの炎症モデルにおいては、T細胞上のCD69分子が炎症の誘導に重要であることが明らかとなった。

Research Products

• [Journal Article] Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene (2008)
  • Author(s): Yamashita, M., Kuwahara, M., Suzuki,A., Hirahara, K., Shinnakasu, R.,Hosokawa, H., Hasegawa, A., Motohashi,S., Iwama, A. and Nakayama, T.
  • Journal Title: J. Exp.Med. 205 Pages: 1109-20
  • Peer Reviewed
• [Journal Article] Human byLipoarabinomannan/Lipomannan fromMycobactrium bovis BCG Tokyo-172 (2008)
  • Author(s): Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y.,Taniguchi, M., Yano, I. and Nakayama, T.
  • Journal Title: Int. Immunol. 20 Pages: 849-860
  • Peer Reviewed
• [Journal Article] Lymphoid enhancer factor interactswith GATA-3 and controls its functionin T helper type2 cells (2008)
  • Author(s): Hossain, M.B., Hosokawa, H., Hasegawa,A., Watarai, H., Taniguchi, M.,Yamashita, M. and Nakayama, T.
  • Journal Title: Immunology 125 Pages: 377-386
  • Peer Reviewed
• [Journal Article] ROG, repressor ofGATA, regulates Th2-driven allergicairway inflammation and airway hyperresponsiveness (2008)
  • Author(s): Hirahara, K., Yamashita, M., Iwamura,C., Shinoda, K., Hasegawa, A.,Yoshizawa, H., Koseki, H., Gejyo, F.,and Nakayama, T.
  • Journal Title: J. Allergy Clin. Immunol 122 Pages: 512-520
  • Peer Reviewed
• [Journal Article] Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation (2008)
  • Author(s): Shinnakasu, R., Yamashita, M.,Kuwahara, M., Hosokawa, H., Hasegawa,A., Motohashi, S. and Nakayama, T.
  • Journal Title: J. Biol. Chem 283 Pages: 28216-28225
  • Peer Reviewed
• [Journal Article] Bmil regulates memory CD4 T cell survival via repression of the Noxa gene. (2008)
  • Author(s): Yamashita, M.
  • Journal Title: J. Exp. Med. 205 Pages: 1109-1120
  • Peer Reviewed
• [Journal Article] Human Th1 cell differentiation induced by Lipoarabinomannan/Lipomannan from Mycobactrium bovis BCG Tokyo-172. (2008)
  • Author(s): Ito, T.
  • Journal Title: Int. Immunol. 20 Pages: 849-860
  • Peer Reviewed
• [Journal Article] Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type2 cells. (2008)
  • Author(s): Hossain, M. B.
  • Journal Title: Immunology 125 Pages: 377-386
  • Peer Reviewed
• [Journal Article] ROG, repressor of GATA, regulates Th2-driven allergic airway inflammation and airway hyperresponsiveness. (2008)
  • Author(s): Hirahara, K.
  • Journal Title: J. Allergy Clin. Immunol. 122 Pages: 512-520
  • Peer Reviewed
• [Journal Article] Gfil-mediated stabilization of GATA3 protein is required for Th2 celldifferentiation. (2008)
  • Author(s): Shinnakasu, R.
  • Journal Title: J. Biol. Chem. 283 Pages: 28216-28225
  • Peer Reviewed
• [Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells (2007)
  • Author(s): Kaneko, T., Hosokawa, H., Yamashita,M., Wang, C., Hasegawa, A., Kimura, Y.M., Kitajima, M., Kimura, F., Miyazaki,M. and Nakayama, T.
  • Journal Title: Mol. Immunol 44 Pages: 2249-2256
  • Peer Reviewed
• [Journal Article] Schnurri-2 controls memory Th1 and th2 cell numbers in vivo (2007)
  • Author(s): Kimura, Y. M., Iwamura, C., Suzuki, A.,Miki, T., Hasegawa, A., Sugaya, K.,Yamashita, M., Ishii, S. and Nakayama,T.
  • Journal Title: J. Immunol 178 Pages: 4926-4936
  • Peer Reviewed
• [Journal Article] Schnurri-2 controls the generation of memory Th1 and Th2 cells (2007)
  • Author(s): Kimura, Y.M., Iwamura, C., Suzuki, A.,Kitajima, M., Hosokawa, H., Hasegawa, A., Yamashita, M., and Nakayama, T.
  • Journal Title: 13th International congress of Immunology Pages: 475-479
• [Journal Article] Schnurii-2 regulates Th2-dependent airway inflammation and aireway hyperresponsiveness (2007)
  • Author(s): Iwamura, C., Kimura, Y. M., Shinoda,K., Endo, Y., Hasegawa, A., Yamashita,M. and Nakayama, T.
  • Journal Title: Int. Immunol 19 Pages: 755-762
  • Peer Reviewed
• [Journal Article] Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells (2007)
  • Author(s): Kaneko, T.
  • Journal Title: Mol. Immunol 44 Pages: 2249-2256
  • Peer Reviewed
• [Journal Article] Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo (2007)
  • Author(s): Kimura, Y. M.
  • Journal Title: J. Immunol 178 Pages: 4926-4936
  • Peer Reviewed
• [Journal Article] Schnurri-2 regulates T_h2-dependent airway inflammation and airway hyper responsiveness (2007)
  • Author(s): Iwamura, C.
  • Journal Title: Int. Immunol 19 Pages: 755-762
  • Peer Reviewed
• [Journal Article] Schnurri-2 controls the generation of memory Th1 and Th2 cells. pp. (2007) (2007)
  • Author(s): Kimura, Y. M.
  • Journal Title: 13th International congress of Immunology Pages: 475-479
• [Presentation] 腸炎の発症におけるCD69分子の役割 (2009)
  • Author(s): 長谷川明洋、白井睦訓
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
• [Presentation] BCGTokyo-172から分離精製したLAM/LM 分子によるHuman Th1分化誘導機構/Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172 (2008)
  • Author(s): Ito, T., Hirasaki, Y., Hasegawa, A.,Hosokawa, H., Motohashi, S.,Yamashita, M., Ishii, Y., Taniguchi,M., Yano, I. and Nakayama, T.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Crucial role for CD69 in the pathogenesis of colitis induced by dextran sulphate sodium (2008)
  • Author(s): Hasegawa, A., Shirai, M. and Nakayama, T.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] アレルギー・喘息のバイオイメージング (2008)
  • Author(s): 長谷川明洋
  • Organizer: 第17回日本バイオイメージング学会学術集会公開シンポジウム
  • Place of Presentation: 千葉
• [Presentation] In vivo imaging in the asthmatic lung (2008)
  • Author(s): Hasegawa, A.
  • Organizer: 第17回日本バイオイメージング学会学術集会シンポジウム
  • Place of Presentation: 千葉
• [Presentation] In vivo imaging in the asthmatic lung. (2008)
  • Author(s): Hasegawa, A.
  • Organizer: 第17回日本バイオイメージング学会学術集会シンポジウム
  • Place of Presentation: 千葉
• [Presentation] BCG Tokyo-172から分離精製したLAM/LM分子によるHuman Th1分化誘導機構/Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172. (2008)
  • Author(s): Ito, T.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Crucial role for CD69 in the pathogenesis of colitis induced by dextran sulphate sodium. (2008)
  • Author(s): Hasegawa, A.
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
• [Presentation] Visualization of lymphocyte migration in the asthmatic lung (2007)
  • Author(s): Hasegawa, A.
  • Organizer: 第37回日本免疫学会総会・学術集会シンポジウム
  • Place of Presentation: 東京
• [Presentation] Hoffman喘息の発症にともなう肺へのT細胞浸潤のイメージング (2007)
  • Author(s): 中山俊憲、長谷川明洋、Robert M.
  • Organizer: 第16回日本バイオイメージング学会学術集会
  • Place of Presentation: 千葉
• [Presentation] Schnurii-2 controls memory Th1 and Th2 cell numbers in vivo (2007)
  • Author(s): Nakayama, T., Kimura, M. Y., Iwamura, C., Hasegawa, A. and Yamashita, M.
  • Organizer: 94^<th> AnnualMeeting of The American Association ofImmunologists, Inc
  • Place of Presentation: Miami Beach、Florida、USA
• [Presentation] GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice (2007)
  • Author(s): Hasegawa, A. and Nakayama, T.
  • Organizer: 94^<th> Annual Meeting of The AmericanAssociation of Immunologists, Inc
  • Place of Presentation: Miami Beach、Florida、USA
• [Presentation] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice (2007)
  • Author(s): Hasegawa, A.
  • Organizer: Immunology 2007, Block symposium
  • Place of Presentation: Miami beach,FL,USA
• [Presentation] Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo (2007)
  • Author(s): Nakayama, T
  • Organizer: Immunology2007, Block symposium.
  • Place of Presentation: Miami beach,FL,USA
• [Presentation] 喘息の発症にともなう肺へのT細胞浸潤のイメージング (2007)
  • Author(s): 中山 俊憲
  • Organizer: 第16回日本バイオイメージング学会学術集会
  • Place of Presentation: 千葉
• [Presentation] Visualization of lymphocyte migration in the asthmatic lung (2007)
  • Author(s): Hasegawa, A
  • Organizer: 第37回日本免疫学会総会・学術集会シンポジウム
  • Place of Presentation: 品川
• [Book]
  • URL: http://mb.med.yamaguchi-u.ac.jp/