Mechanisms for the differentiation and maturation of cells of the innate immune system and their dysregulation underlying abnormal acquired immunity

• Project/Area Number: 19590494
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Shinshu University
• Principal Investigator: TAKI Shinsuke Shinshu University, 大学院・医学系研究科, 教授 (50262027)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: サイトカイン / NK細胞 / 炎症 / 好塩基球 / NK受容体 / 自然免疫 / T細胞 / インターロイキン2 / インターロイキン3 / インターロイキン4 / 免疫系 / 樹状細胞 / 転写制御因子 / I型インターフェロン / インターフェロンγ / 皮膚炎症 / 遺伝子支配 / 遺伝子欠損マウス

Research Abstract

本研究では、遺伝子発現調節因子であるインターフェロン制御因子2(IRF-2)を遺伝的に欠損するマウスにおいて、第4および10染色体上の1型インターフェロン(IFN)応答を調節する遺伝子座が皮膚炎症の発症に影響を与えること、それはCD8+T細胞の2型IFN(IFN-g)産生の制御を介していることを明らかにした。一方、活性化ナチュラルキラー細胞がB細胞の分化を抑制していること、その機構にもIFN-gが関与していることを見いだした。

Research Products

• [Journal Article] Fc receptor g-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils (2009)
  • Author(s): Hida, S, Yamasaki, S, Sakamoto, Y, Takamoto, M, Obata, K, Takai, T, Karasuyama, H, Sugane, K, Saito, T, Taki, S
  • Journal Title: Nature Immunol 10 Pages: 214-222
  • Peer Reviewed
• [Journal Article] Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways (2009)
  • Author(s): Nagumo, H, Abe, J, Kano, H, Taki, S, Yamazaki, K, Yamazaki, T, Kobayashi, N, Koike, K, Sugane, K, Saito, H, Agematsu, K
  • Journal Title: Cell. Immunol 256 Pages: 56-63
  • Peer Reviewed
• [Journal Article] STAT6 signalling is important in CD8^+ T-cell activation and defence against Toxoplasma gondii infection in the brain (2009)
  • Author(s): Jin, D, Takamoto, M, Hu, T, Taki, S, Sugane, K
  • Journal Title: Immunology 127 Pages: 187-195
  • Peer Reviewed
• [Journal Article] Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. (2009)
  • Author(s): Hida, S, Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sueane, K., Saito, T., Taki, S
  • Journal Title: Nature Immunology 10 Pages: 214-222
  • Peer Reviewed
• [Journal Article] IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1^+B220^+ NK cells Biochem. Biophys. Res (2008)
  • Author(s): Nakajima, S, Hida, S, Taki, S
  • Journal Title: Commun 369 Pages: 1139-1143
  • URL: http://hdl.handle.net/10091/1090
  • Peer Reviewed
• [Journal Article] Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling (2008)
  • Author(s): Mizutani, T, Tsuji, K, Ebihara, Y, Taki, S, Ohba, Y, Taniguchi, T, Honda, K
  • Journal Title: Exp. Hematol 36 Pages: 255-364
  • Peer Reviewed
• [Journal Article] Genetic control directed towards spontaneous IFN-α/β responses and downstream IFN-γ expression influences the pathogenesis of a murine psoriasis-like skin disease (2008)
  • Author(s): Arakura, F, Hida, S, Ichikawa, E, Yajima, C, Nakajima, S, Saida, T, Taki, S
  • Journal Title: J. Immunol 179 Pages: 3249-3257
  • Peer Reviewed
• [Journal Article] STAT6 signalling is important in CD8^+ T-cell activation and defence against Toχoplasma gondii infection in the brain. in press. (2008)
  • Author(s): Jin, D., Takamoto, M., Hu, T., Taki, S., Sugane, K.
  • Journal Title: Immunology (印刷中)
  • Peer Reviewed
• [Journal Article] IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1^+B220^+NK cells. (2008)
  • Author(s): Nakajima, S., Hida, S., Taki, S.
  • Journal Title: Biochem. Biophys. Res. Commun. 369 Pages: 1139-1143
  • Peer Reviewed
• [Journal Article] Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling. (2008)
  • Author(s): Mizutani, T., Tsuji, K., Ebihara, Y., Taki, S., Ohba, Y., Taniguchi, T., Honda, K.
  • Journal Title: Experimental Hematology 36 Pages: 255-264
  • Peer Reviewed
• [Journal Article] IL-15 inhibits pre-B cell proliferation by selectively expanding Mac_1^+B220^+ NK cells (2008)
  • Author(s): Shinsuke Nakajima, 他
  • Journal Title: Biochem. Biophys. Res. Comunic. 369 Pages: 1139-1143
  • Peer Reviewed
• [Journal Article] Homeostatic erythropoiesis by the transcription factor 工RF2 through attenuation of type I interferon signaling (2008)
  • Author(s): Tatsuaki Mizutani, 他
  • Journal Title: Exp. Hematol. 36 Pages: 255-264
  • Peer Reviewed
• [Journal Article] 2型免疫応答制御細胞としての好塩基球 (2008)
  • Author(s): 瀧伸介
  • Journal Title: 医学のあゆみ 224 Pages: 238-239
• [Journal Article] 移植を成立させる生体反応へのアプローチのための移植免疫 (2008)
  • Author(s): 瀧伸介
  • Journal Title: 薬局(増刊) 59 Pages: 1578-1581
• [Journal Article] Genetic control directed towards spontaneous IFN-α/β responses and downstream IFN-γ expression influences the pathogenesis of a murine psoriasis-like skin disease. (2007)
  • Author(s): Arakura, F., Hida, S., Ichikawa, E., Yajima, C., Nakajima, S., Saida, T., Taki., S.
  • Journal Title: Journal of Immunology 179 Pages: 3249-3257
  • Peer Reviewed
• [Journal Article] Genetic control directed towards spontaneous IFN-α/β(responses and downstream IFN-γ expression influences the pathogenesis of a murine psoriasis-like skin disease (2007)
  • Author(s): Fuyuko Arakura, 他
  • Journal Title: Journal of Immunology 179 Pages: 3249-3257
  • Peer Reviewed
• [Presentation] Basophils affect the homeostasis regulation of Thl/Th2 balance. (2007)
  • Author(s): Taki, S.
  • Organizer: World allergy congress 2007
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2007-12-04
• [Presentation] Basophils affect the homeostasis regulation of Th1/Th2 balance (2007)
  • Author(s): Shinsuke Taki
  • Organizer: World Allergy Congress 2007
  • Place of Presentation: Bangkok
  • Year and Date: 2007-12-04
• [Presentation] Basophils affect the homeostasis regulation of Th1/Th2 balance (2007)
  • Author(s): Taki, S
  • Organizer: World allergy congress 2007
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2007-12-01
• [Presentation] Fc receptor-γ chain is a subunit of IL-3 receptor complexes, required for IL-4 expression by but not proliferation of murine basophils. (2007)
  • Author(s): 肥田重明, ほか
  • Organizer: 日本免疫学会第37回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Paired immunoglobulin-like receptor(PIR)-B regulates IL-3 responses in basophils. (2007)
  • Author(s): 菊池宏美, ほか
  • Organizer: 日本免疫学会第37回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Positive and negative regulation of IL-3 signals in murine basophils, important for controlling Th2 develpment. (2007)
  • Author(s): Shinsuke Taki
  • Organizer: JSI-RCAI Interbational Symposium on Immunology
  • Place of Presentation: Yokohama
  • Year and Date: 2007-07-26
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_frame.html
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/zouki/immunol/main_franie.htm
• [Remarks]
  • URL: http://dept.md.shinshu-u.ac.jp/immunol/main_frame.htm