Immune regulation of intestinal homeostasis by NOD2 activation
| Project/Area Number |
19590495
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
WATANABE Tomohiro Kyoto University, 医学研究科, 助教 (40444468)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | サイトカイン / 自然免疫 / クローン病 / NOD2 / TLR / IRF4 / NF-kappaB |
|---|
| Research Abstract |
Nucleotide binding oligomerization domain 2(NOD2)の活性化が腸内細菌によるToll-like receptor(TLR)の活性化を抑制することにより、腸炎の発症を未然に防止していること及びその分子機序を明らかにした。
|
Report
(3 results)
Research Products
(7 results)
