Immune regulation of intestinal homeostasis by NOD2 activation

• Project/Area Number: 19590495
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Kyoto University
• Principal Investigator: WATANABE Tomohiro Kyoto University, 医学研究科, 助教 (40444468)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: サイトカイン / 自然免疫 / クローン病 / NOD2 / TLR / IRF4 / NF-kappaB

Research Abstract

Nucleotide binding oligomerization domain 2(NOD2)の活性化が腸内細菌によるToll-like receptor(TLR)の活性化を抑制することにより、腸炎の発症を未然に防止していること及びその分子機序を明らかにした。

Research Products

• [Journal Article] Muramyl dipeptide activation of nucleotide binding oligomerization domain 2 protects mice from experimental colitis (2008)
  • Author(s): Watanabe T, Asano N, Murray PJ, Ozato K, Tailor P, Fuss IJ, Kitani A, Strober W.
  • Journal Title: Journal of Clinical Investigation 118 Pages: 545-59
  • Peer Reviewed
• [Journal Article] The molecular basis of NOD2 susceptibility mutations in Crohn's disease (2008)
  • Author(s): Strober W, Kitani A, Fuss IJ, Asano N, Watanabe T.
  • Journal Title: Mucosal Immunology 1 Pages: 5-9
  • Peer Reviewed
• [Journal Article] Muramyl dipeptide activation of NOD2 protects mice from experimental colitis (2008)
  • Author(s): Tomohiro Watanabe, et al.
  • Journal Title: Journal of Clinical Investigation 118 Pages: 545-559
  • Peer Reviewed
• [Journal Article] Muramyl dipeptide activation of NOD2 protects mice from experimental colitis (2008)
  • Author(s): Watanabe T, et. al.
  • Journal Title: Journal of Clinical Investigation 118 Pages: 545-559
  • Peer Reviewed
• [Journal Article] NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis-induction. (2007)
  • Author(s): Yang Z, Fuss IJ, Watanabe T, Asano N, Davey MP, Rosenbaum JT, Strober W, and Kitani A.
  • Journal Title: Gastroenterology 133 Pages: 1510-21
  • Peer Reviewed
• [Presentation] Muramyl dipeptide activation of NOD2 protects mice from experimental colitis (2008)
  • Author(s): Tomohiro Watanabe
  • Organizer: Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2008-12-03
• [Presentation] Muramyl didpeptide activation of Nucleotide binding oligomerization domain 2 protects mice from experimental colitis (2008)
  • Author(s): Tomohiro Watanabe
  • Organizer: Muramyl didpeptide activation of Nucleotide binding oligomerization domain 2 protects mice from experimental colitis
  • Place of Presentation: Kyoto. Symposium : Mucosal immunology