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Research for signaling mechanisms and physiological roles of ITAM-coupling receptors

Research Project

Project/Area Number 19590498
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionSaga University

Principal Investigator

HARA Hiromitsu  Saga University, 医学部, 准教授 (20392079)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Hiroki  佐賀大学, 医学部, 教授 (40260715)
KOSUGI Isao  浜松医科大学, 医学部, 准教授 (10252173)
HAMANO Shinjiro  九州大学, 医学研究院, 助教 (70294915)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords免疫学 / シグナル伝達 / 感染症 / アレルギー・ぜんそく / ITAM / NK細胞 / リーシュマニア / NF-кB / CARD9 / CARMA1 / Bcl10 / 自然免疫 / アレルギー・喘息
Research Abstract

今回の補助金を得て, リンパ球系細胞では, PKC活性化に依存したCARMA1-BCL10複合体が, マクロファージや樹状細胞などの骨髄系細胞では, PKCに依存しないCARD9-BCL10複合体が, ITAM受容体を介したNF-κB活性化とサイトカイン遺伝子の発現等の免疫反応に必須であることが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (17 results)

  • [Journal Article] CARD9 vs. CARMA1 in innate and adaptive immunity2009

    • Author(s)
      Hara H and Saito T
    • Journal Title

      Trends in immunol 30(5)

      Pages: 234-242

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CARD9 vs. CARMA1 in innate and adaptive immunity2009

    • Author(s)
      Hiromitsu Hara
    • Journal Title

      Trends in Immunology 30

      Pages: 234-242

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-type lectin Mincle is an ITAM-coupled activating receptor2008

    • Author(s)
      Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K and Saito T
    • Journal Title

      Nat Immunol 9(10)

      Pages: 1179-1188

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell-type-Specific regulation of ITAM-mediated NF-κB acdvation by adaptors CARMA1 and CARD92008

    • Author(s)
      Hara H, Ishihara C, (以下4名略)
    • Journal Title

      J. Immunol 181(2)

      Pages: 918-930

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell-type-specific regulation of ITAM-mediated NF-кB activation by adaptors CARMA1 and CARD92008

    • Author(s)
      Hiromitshu Hara
    • Journal Title

      The Journal of Immunology 181

      Pages: 918-930

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リンパ系細胞と骨髄系細胞におけるNF-кB活性化, MAPK活性化誘導アダプターの相違2008

    • Author(s)
      原博満
    • Journal Title

      臨床免疫・アレルギー科 49

      Pages: 357-364

    • Related Report
      2008 Annual Research Report
  • [Journal Article] The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors2007

    • Author(s)
      Hara H, Ishihara C, (以下14名略)
    • Journal Title

      Nat Immunol 8(6)

      Pages: 619-29

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] TLR2 directly triggers Th1 effector functions2007

    • Author(s)
      Imanishi T, Hara H, Suzuki S, Suzuki N, Akira S and Saito T
    • Journal Title

      J. Immunol 178(11)

      Pages: 6715-6719

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways2007

    • Author(s)
      Shambharkar PB, Blonska M, Pappu BP, Li H, You Y, Sakurai H, Darnay BG, Hara H, Penninger JM, Lin X
    • Journal Title

      EMBO J 26(7)

      Pages: 1794-805

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors2007

    • Author(s)
      原博 満, 他15名
    • Journal Title

      Nature Immunology 8

      Pages: 619-629

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] CARD9を介した自然免疫活性化経路の原虫感染防御における役割2009

    • Author(s)
      原博満, 島ノ江洋平, 宮崎義之, 吉田裕樹
    • Organizer
      第78回日本寄生虫学会大会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] CARMA1とCARD9により制御される細胞種特異的なITAMを介したNF-κB活性化機構2008

    • Author(s)
      原博満, 吉田裕樹, 斉藤隆
    • Organizer
      第38回日本免疫学会学術集
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of CARD9 in anti-protozoan defense2008

    • Author(s)
      島ノ江洋平, 宮崎義之, 原博満, 吉田裕樹
    • Organizer
      第38回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] CARMA1とCARD9により制御される細胞種特異的なITAMを介したNF-кB活性化機構2008

    • Author(s)
      原博満
    • Organizer
      第38回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of CARD9 in anti-protozoan defence2008

    • Author(s)
      島ノ江洋平
    • Organizer
      第38回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of CARD9 in anti-protozoan defense2008

    • Author(s)
      Yohei Shimanoe, Hara, Hiromitsu, Yoshida, Hiroki
    • Organizer
      The 8th Awaji International forum on Infection and Immunigy
    • Place of Presentation
      淡路
    • Year and Date
      2008-09-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of CARD9 in anti-protozoan defence2008

    • Author(s)
      吉田裕樹
    • Organizer
      The 8th Awaji International forum on Infection and Immunigy
    • Place of Presentation
      淡路
    • Year and Date
      2008-09-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] ITAMを介した細胞種特異的なNF-κB活性化機構3大会合同大会20082008

    • Author(s)
      原博満
    • Organizer
      第73回日本インターフェロンサイトカイン学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-11
    • Related Report
      2008 Final Research Report
  • [Presentation] ITAMを介した細胞種特異的なNF-кB活性化機構2008

    • Author(s)
      原博満
    • Organizer
      3大会合同大会2008(第73回日本伊インターフェロンサイトカイン学会学術集会)
    • Place of Presentation
      札幌
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新しい原虫感染防御因子CARD92008

    • Author(s)
      吉田裕樹, 島ノ江洋平, 王森, 宮崎義之, 原博満
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2008-04-02
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Differential regulation of innate immune signaling through Carmal and CARD92007

    • Author(s)
      原博満
    • Organizer
      日本免疫学会学術集会国際シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Differential regulation of innate immune signaling through Carma1and CARD92007

    • Author(s)
      原博 満, 他5名
    • Organizer
      日本免疫学会学術集会 国際シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Differential requirement of Carmal and CARD9 for FcR γ/DAP12-mediated activation of NF-κB in NK cells and myeloid cells2007

    • Author(s)
      原博満
    • Organizer
      13th International congress of Immunology
    • Place of Presentation
      ブラジル・リオデジャネイロ
    • Year and Date
      2007-08-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Differential requirement of Carma1and CARD9 for FcRγ/DAP12-mediated activation of NF-κB in NK cells and myeloid cells2007

    • Author(s)
      原博 満, 他5名
    • Organizer
      13th International congress of Immunology
    • Place of Presentation
      ブラジル・リオデジャネイロ
    • Year and Date
      2007-08-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] CARD9とCARD11によるITAM関連受容体を介したサイトカイン産生の制御2007

    • Author(s)
      原博満
    • Organizer
      72回日本インターフェロンサイトカイン学会
    • Place of Presentation
      京都
    • Year and Date
      2007-07-06
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Card9 is essential for myeloid cell activation through ITAM-bearing receptors2007

    • Author(s)
      原博満
    • Organizer
      Keystone svmoosia
    • Place of Presentation
      アメリカ・キーストン
    • Year and Date
      2007-02-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Card9 is essential for myeloid cell activation through ITAM-bearing receptors2007

    • Author(s)
      原博 満, 他4名
    • Organizer
      Keystone symposia
    • Place of Presentation
      アメリカ・キーストン
    • Year and Date
      2007-02-26
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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