Regulation of dendritic cell activation through the PI3K-p38 MAPK

• Project/Area Number: 19590499
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Kansai Medical University
• Principal Investigator: MATSUDA Satoshi Kansai Medical University, 医学部, 准教授 (00286444)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 樹状細胞 / 免疫応答 / MAPK / サイトカイン / PI3K / h1 / Th2 バランス / IL-10 / mTOR / IL-12 / Akt / p38MAPK / 免疫学 / Th1 / Th2バランス

Research Abstract

PI3K経路が、マウス樹状細胞において、mTOR経路・GSK3経路・p38 MAPK経路の少なくとも3つの経路を介して、IL-12産生をはじめとする免疫調整能の制御を行っていることを明らかにした。これまで他の細胞で得られてきた結果と異なり、PI3Kはp38MAPKの活性化を負に制御していることから、樹状細胞においては全く新規のMAPK制御機構が機能するものと推測される。

Research Products

• [Journal Article] Critical role of class IA PI3K for c-Rel expression in B lymphocytes (2009)
  • Author(s): Matsuda, S., Mikami, Y., Ohtani, M., Fujiwara, M., Hirata, Y., Minowa, A., Terauchi, Y., Kadowaki, T., and Koyasu, S.
  • Journal Title: Blood 113(5) Pages: 1037-1044
  • Peer Reviewed
• [Journal Article] 樹状細胞のシグナル伝達 (2009)
  • Author(s): 大谷真志, 小安重夫, 松田達志
  • Journal Title: 肝胆膵 58(2) Pages: 185-192
• [Journal Article] Critical role of class IA PI3K for c-Rel expression in B lymphocytes. (2009)
  • Author(s): Satoshi Matsuda, et al.
  • Journal Title: Blood 113 Pages: 1037-1044
  • Peer Reviewed
• [Journal Article] 樹状細胞のシグナル伝達 (2009)
  • Author(s): 大谷真志, 小安重夫, 松田達志
  • Journal Title: 肝胆膵 58 Pages: 185-192
• [Journal Article] mTOR and GSK3 differentially regulate LPS-induced IL-12 production in dendritic cells (2008)
  • Author(s): Ohtani, M., Nagai, S., Kondo, S., Mizuno, S., Nakamura, K., Tanabe, M., Takeuchi, T., Matsuda, S., and Koyasu, S.
  • Journal Title: Blood 112(3) Pages: 635-643
  • Peer Reviewed
• [Journal Article] ERK5 is involved in TCR-induced apoptosis through the modification of Nur77 (2008)
  • Author(s): Fujii, Y., Matsuda, S., Takayama, G., and Koyasu, S.
  • Journal Title: Genes Cells 13(5) Pages: 411-419
  • Peer Reviewed
• [Journal Article] mTOR and GSK3 differentially regulate LPS-induced IL-12 production in dendritic cells. (2008)
  • Author(s): Masashi Ohtani, et al.
  • Journal Title: Blood 112 Pages: 635-643
  • Peer Reviewed
• [Journal Article] ERK5 is involved in TCR-induced apoptosis through the modification of Nur77 (2008)
  • Author(s): Yasushi Fujii, et. al.
  • Journal Title: Genes to Cells 13 Pages: 411-419
  • Peer Reviewed
• [Journal Article] mTOR and GSK3 differentially regulate LPS-induced IL-12 production in dendritic cells (2008)
  • Author(s): Masashi Ohtani, et. al.
  • Journal Title: Blood (in press)
  • Peer Reviewed
• [Journal Article] 小安重夫 TLR 刺激樹状細胞からのIL-12生産におけるシグナル伝達 (2007)
  • Author(s): 松田達志, 小安重夫
  • Journal Title: 臨床免疫・アレルギー科 48(3) Pages: 307-313
• [Journal Article] フローサイトメトリーの原理、技術革新 (2007)
  • Author(s): 松田達志、小安重夫
  • Journal Title: 臨床検査 51(9) Pages: 907-914
• [Presentation] mTOR and GSK3 differentially regulate LPS-induced IL-12 production in dendritic cells (2008)
  • Author(s): Ohtani, M., Nagai, S., Kondo, S., Mizuno, S., Nakamura, K., Tanabe, M., Takeuchi, T., Matsuda, S., and Koyasu, S.
  • Organizer: 第10回国際樹状細胞シンポジウム
  • Place of Presentation: 神戸
• [Presentation] T細胞におけるIL-2発現に関わるPI3Kγの役割 (2008)
  • Author(s): 高山源介、 松田達志、小安重夫
  • Organizer: 第18回Kyoto T cell Conference
  • Place of Presentation: 京都
• [Presentation] Class IA PI3K経路はB細胞におけるc-Relの発現制御に関与している (2008)
  • Author(s): 松田達志
  • Organizer: 基生研研究会「リン酸化シグナルの統合的解明を目指して」
  • Place of Presentation: 岡崎
• [Presentation] mTOR and GSK3 differentially regulate LPS-induced IL-12 production in dendritic cells. (2008)
  • Author(s): Masashi Ohtani, et al.
  • Organizer: 第10回国際樹状細胞シンポジウム
  • Place of Presentation: 神戸
• [Presentation] class IA PI3K経路はB細胞におけるc-Relの発現制御に関与している (2008)
  • Author(s): 松田達志
  • Organizer: 基生研研究会「リン酸化シグナルの統合的解明を目指して」
  • Place of Presentation: 岡崎
• [Presentation] Suppressive effects of CD4+CD25+ regulatory T cells in Pemphigus Vulgaris model mice (2007)
  • Author(s): Yokoyama, T., Takae, Y., Amagai, M., Matsuda, S., and Koyasu, S.
  • Organizer: 第37回日本免疫学会総会・学術集会(ワークショップ)
  • Place of Presentation: 品川
• [Presentation] The role of p85α PI3K regulatory subunit in maintenance of mast cell progenitor in mouse small intestine (2007)
  • Author(s): Minowa, A., Matsuda, S., Hiromatsu, K., and Koyasu, S
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 品川
• [Remarks] ホームページ
  • URL: http://www3.kmu.ac.jp/bioinfo/
• [Remarks]
  • URL: http://www3.kmu.ac.jp/bioinfo/index.html