Identification of prethymic T cell progenitors in adult mice

• Project/Area Number: 19590500
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Nihon University
• Principal Investigator: KATSURA Yoshimoto Nihon University, 医学部, 兼任講師 (90027095)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: T細胞 / 分化 / 造血幹細胞

Research Abstract

γ線を照射し、骨髄細胞を移植して1週間後のマウスの脾臓中に、多数のT前駆細胞が存在する事が明らかになった。このT前駆細胞はわれわれが胎児肝臓中に同定していたものと同じく、ナチュラルキラー細胞と樹状細胞もつくる。一方、成体胸腺中の最も初期の細胞も同じ性質を示す事が示された。これらの結果は、T系列とB系列は独立に、ミエロイド系列と関連して分化するというわれわれのミエロイド基本型モデルを実証するものである。

Research Products

• [Journal Article] Adult T-cell progenitors retain myeloidpotential (2008)
  • Author(s): Wada H,Masuda K,Satoh R, Kakugawa K, Ikawa T, Katsura Y, Kawamoto H
  • Journal Title: Nature 452 Pages: 768-772
  • Peer Reviewed
• [Journal Article] T前駆細胞の発生:T細胞系列のアイデンティティー (2008)
  • Author(s): 河本宏、桂義元
  • Journal Title: メディカルバイオ 5 Pages: 32-38
• [Journal Article] Adult T-cell progenitors retain myeloid potential (2008)
  • Author(s): Wada H, Masuda K, Sato R, Iwata T, Katura Y, Kawamoto H
  • Journal Title: Nature 452 Pages: 768-772
  • Peer Reviewed
• [Journal Article] T前駆細胞の発生 (2008)
  • Author(s): 河本 宏, 桂 義元
  • Journal Title: メディカルバイオ 5 Pages: 32-38
• [Journal Article] T cell lineage determination precedes the initiation of TCRbeta gene rearrangement (2007)
  • Author(s): Masuda K,Kakugawa K,Nakayama T,Minato M,Katsura Y,Kawamoto H
  • Journal Title: Journal of Haematology 179 Pages: 3699-3706
  • Peer Reviewed
• [Journal Article] Quantification of Progenitors capable of generating T cell In human cord blood (2007)
  • Author(s): Kato M, Masuda K, Kakugawa K, Kawamoto H, Mugishima H, Katsura Y
  • Journal Title: European Journal of Haematology 80(2) Pages: 151-159
  • Peer Reviewed
• [Journal Article] Quantification of progenitors capable of generating T cells in humancord blood. (2007)
  • Author(s): Kato M, Masuda K, Kakugawa K, Kawamoto H, Mugishima H, Katsura Y
  • Journal Title: European Journal of Haematology 80(2) Pages: 151-159
  • Peer Reviewed
• [Journal Article] T cell lineage determination precedes the initiation of TCRbeta gene rearrengement. (2007)
  • Author(s): Masuda K, Kakugawa K, Nakayama T, Minato M, Katsura Y, Kawamoto H
  • Journal Title: Journal of Immunology 179 Pages: 3699-3706
  • Peer Reviewed
• [Presentation] Thymic cortical epithelial cells are generated in two separate waves (2007)
  • Author(s): 佐藤留美、桂義元、Ewijk W.v.、河本宏
  • Organizer: 第37回日本免疫学会総会・学術集会(特定非営利活動法人 日本免疫学会)
  • Place of Presentation: 東京
• [Presentation] 胸腺皮質の修復再生機構 (2007)
  • Author(s): 佐藤瑠美、桂義元、Ewijk W.v.、河本宏
  • Organizer: 第17回Kyoto cell Conference (第17回KTCC事務局)
  • Place of Presentation: 京都
• [Presentation] Thymic cortical epithelial cell are generated in two separate waves. (2007)
  • Author(s): 佐藤 瑠美, 桂 義元,
  • Organizer: 第17回Kyoto T Cell Conference
  • Place of Presentation: 京都