The role of interleukin-33 on the murine model of experimental asthma

• Project/Area Number: 19590501
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Hyogo College of Medicine
• Principal Investigator: MATSUMOTO Makoto Hyogo College of Medicine, 医学部, 助教 (40380521)
• Co-Investigator(Kenkyū-buntansha): NAKANISHI Kenji 兵庫医科大学, 医学部, 教授 (60172350)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: アレルギー・喘息 / 免疫学 / サイトカイン / アレルギー・せんそく

Research Abstract

インターロイキン33の点鼻投与によりマウスに喘息様症状を惹起させることが出来た。T 細胞、B細胞等の獲得免疫系細胞を有さないマウスにおいてもインターロイキン33は喘息様症状を惹起させた。この結果はインターロイキン33の点鼻投与は自然免疫型喘息のモデルとなり得ることを示している。一方、試験管内においてインターロイキン33は好塩基球に働き、2型ヘルパーT細胞の分化に必須であるインターロイキン4の産生を促すことが分かった。

Research Products

• [Journal Article] Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. (2009)
  • Author(s): Yuichi Kondo
  • Journal Title: International Immunology 20 Pages: 791-800
  • Peer Reviewed
• [Journal Article] Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. (2008)
  • Author(s): Yuichi Kondo, Tomohiro Yoshimoto. Koubun Yasuda Shizue Futatsugi-Yumikura, Mai Morimoto, Nobuki Hayashi, Tomoaki Hoshino, Jiro Fujimoto and Kenji Nakanishi
  • Journal Title: International Immunology vol.20 Pages: 791-800
  • NAID: 10021241671
  • Peer Reviewed
• [Journal Article] T heper1 cells stimulated with ovalbumin and IL-18 induces airway hyperresponsiveness and lung fibrosis by IFN-γ and IL-13 production. (2007)
  • Author(s): Nobuki Hayashi, Tomohiro Yoshimoto, Kenji Izuhara, Kiyoshi Matsui, Toshio Tanaka and Kenji Nakanishi
  • Journal Title: Proceedings of the National Academy of Sciences of the USA. vol.104 Pages: 14765-14770
  • Peer Reviewed
• [Journal Article] T helperl cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-g and IL-13 production (2007)
  • Author(s): Nobuki Hayashi
  • Journal Title: Proceeding of the National Academy of Sciences of the USA 104 Pages: 14765-14770
  • Peer Reviewed
• [Presentation] アレルギー疾患の複数病因論とTh2細胞の誘導機序の多彩さ (2008)
  • Author(s): 中西憲司
  • Organizer: 第58回日本アレルギー学会秋期学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-27
• [Presentation] アレルギー疾患の複数病因論とTh2細胞の誘導機序の多彩さ (2008)
  • Author(s): 中西憲司
  • Organizer: 第58回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-27