Analysis for the function of adaptor protein, BANK which negatively regulates immune response

• Project/Area Number: 19590503
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: AIBA Yuichi The Institute of Physical and Chemical Research, 分化制御研究グループ, 研究員 (00273516)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: B細胞 / アダプター分子

Research Abstract

B細胞応答を負に制御するアダプター分子であるBANKについて、その制御機構、また免疫抑制の意義について解析した。BANKに刺激依存的に結合する85kdの未知のタンパクを発見した。また免疫寛容の誘導時にBANKが関与するかについて、種々の遺伝子改変マウスを用いて解析したが、BANKによる免疫応答の負の制御は免疫寛容の誘導には関与しないことが明らかとなった。一方BANKは抗原刺激後初期の細胞増殖を負に制御することが明らかとなった。

Research Products

• [Journal Article] A Minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical desease (2008)
  • Author(s): Conley ME., Farmer DM., Dobbs AK., Howard V., Aiba Y., Shurtleff SA., Kurosaki T.
  • Journal Title: Clinical and Experimental Immunology Vol. 152 Pages: 39-44
  • Peer Reviewed
• [Journal Article] Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase (2008)
  • Author(s): Aiba Y., Kameyama M., Yamazaki T., Tedder TF., Kurosaki T.
  • Journal Title: Blood Vol. 111 Pages: 1497-1503
  • Peer Reviewed
• [Journal Article] A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease (2008)
  • Author(s): Conley ME, et al
  • Journal Title: Clinical and Experimental Immunology 152 Pages: 39-44
  • Peer Reviewed
• [Journal Article] Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase (2008)
  • Author(s): Aiba Y, et. al.
  • Journal Title: Blood 111 Pages: 1497-1503
  • Peer Reviewed
• [Presentation] BCAP及びCD19分子によるB細胞分化の制御 (2007)
  • Author(s): 饗場 祐一
  • Organizer: 日本免疫学会総会 学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] BCAP及びCD19分子によるB細胞分化の制御 (2007)
  • Author(s): 饗場 祐一, 他
  • Organizer: 日本免疫学会総会.学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20